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Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants

NCT00904774 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 800

Last updated 2009-05-20

No results posted yet for this study

Summary

Despite considerable obstetric and neonatal advances in the care of very low birth weight (VLBW) neonates, bronchopulmonary dysplasia (BPD) continues to occur among 20 to 40% of surviving infants, and new ways for combatting this disease must be found. BPD appears to result from arrested lung development, but its etiology has not yet been fully established. Besides the role of the exposure of the immature lung to injurious factors in the development of BPD, a genetic susceptibility for BPD in preterm infants was recently evidenced. Taking advantage of new genomic technologies, the objective of the investigators' project is to identify predisposing human genetic variants through:

1. a genome-wide association (GWA) study in VLBW neonates,
2. a candidate-gene association study, including selection of single nucleotide polymorphisms (SNPs) found in (a) and
3. functional studies of any SNP found to be convincingly associated with BPD in (a) and (b).

Conditions

  • Bronchopulmonary Dysplasia

Sponsors & Collaborators

  • Centre Hospitalier Intercommunal Creteil

    lead OTHER

Eligibility

Max Age
8 Weeks
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-05-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00904774 on ClinicalTrials.gov