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Study of Normal Intestinal Development and Disease in Premature and Term Neonates

NCT06681129 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2026-03-27

No results posted yet for this study

Summary

Current research on early intestinal development is primarily performed in mouse models. While useful in many other ways, mouse models are not ideal for studying human intestine development as the timing of this process differs between the two species. Further, prior research has demonstrated that some proteins and pathways that are critical in human development have no clear role in mice.

This study aims to improve the overall understanding of critical aspects of intestinal development in humans. In addition, this study will investigate the impact of intestinal diseases that are found in the early stages of life such as necrotizing enterocolitis (NEC).

Conditions

  • NEC
  • Necrotizing Enterocolitis
  • Intestinal Disease
  • Human Development

Sponsors & Collaborators

Principal Investigators

  • Amy O'Connell, MD, PhD · Boston Children's Hospital

Eligibility

Max Age
2 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-03-17
Primary Completion
2031-09-01
Completion
2034-12-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06681129 on ClinicalTrials.gov