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Investigation of Polymorphisms in Bronchopulmonary Dysplasia In Turkish Population

NCT03467828 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 196

Last updated 2019-03-05

No results posted yet for this study

Summary

Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects a ratio of up to 20-30% of infants prematurely born before 30rd week. Delay of starting to speak, cerebral palsy and cognitive disorders may be seen in infants suffering from this disease. Although all the evidence found on the specific mediators and pathways that regulate the mechanism by studies made to understand the pathophysiologic mechanism, there hasn't been any remarkable progress on preventing the development of BPD in new-born infants born below 1500gr body weight. BPD is still one of the most important morbidity and mortality reasons in premature infants. There is a need of further studies to understand the genetic background of BPD specific to different populations, to identify polymorphisms related with the disease and for developing genetic methods for early the diagnose of the disease.

With this purpose, first of all polymorphisms related with BPD and those which are related with similar other lung diseases will be investigated. DNA samples derived from blood samples of 200 patients (100 BPD infant and 100 control) will be examined for polymorphisms in specific genes that are chosen in the light of the prior literature scanning. To the investigators' knowledge, this will be the first study of a broad scanning of polymorphisms related with BPD in Turkish population.

Conditions

  • Bronchopulmonary Displasia

Interventions

GENETIC

polymorphism analyzing

Blood samples will be taken to EDTA containing tubes and then will be analyzed for genetic polymorphisms.

Sponsors & Collaborators

  • Seda Yilmaz Semerci

    lead OTHER

Principal Investigators

  • Seda Yilmaz Semerci · Kanuni Sultan Suleyman Training and Research Hospital

  • Ayberk Akat · Istanbul Demiroglu Bilim University

  • Osman Mutluhan Ugurel · Yildiz Technical University

  • Merih Cetinkaya · Kanuni Sultan Suleyman Training and Research Hospital

  • Dilek Turgut Balık · Yildiz Technical University

Study Design

Allocation
NON_RANDOMIZED
Purpose
SCREENING
Masking
NONE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-07-04
Primary Completion
2018-04-05
Completion
2018-05-24

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03467828 on ClinicalTrials.gov