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Genomics of Chronic Renal Allograft Rejection (The GoCAR Study)

NCT00611702 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 588

Last updated 2015-05-14

No results posted yet for this study

Summary

Doctors have had success preventing certain types of kidney transplant rejection by suppressing the immune system. However, an individual's genetic make-up and the strength of an immune response to a transplant may also determine whether a transplanted organ is rejected. The purpose of this study is to look at the genetic profile and immune response of people who have had kidney transplants and to correlate the findings with kidney transplant rejection episodes. Donor genetic profiles will also be studied and correlated with the recipient's information.

Conditions

  • Kidney Transplantation

Interventions

PROCEDURE

Kidney biopsy

Kidney biopsy (recipients only) will be obtained for RT-PCR, microarray analyses and histology.

Sponsors & Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

    lead NIH

Principal Investigators

  • Barbara T. Murphy, MD · Division of Nephrology, Mt. Sinai School of Medicine

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-06-30
Primary Completion
2013-07-31
Completion
2013-07-31

Countries

  • United States
  • Australia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00611702 on ClinicalTrials.gov