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Analysis of Biopsies With Antibody Mediated Rejection According to the Therapy Response

NCT03430414 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2018-02-12

No results posted yet for this study

Summary

In adult kidney transplant recipients a therapy-responder and non-responder phenotype by antibody mediated rejection will be precisely defined according to clinical and histological characteristics such as creatinine, proteinuria and Banff-classification. Twenty-five patients will be selected each in the therapy-responder and non-responder group. Their stored Formalin Fixed Paraffin Embedded (FFPE) biopsies will be (re)-classified according to the most recent Banff classification. Using Nanostring Technology the gene transcription of therapy-responders versus non-responders will be analyzed and compared to serological and clinical parameters.

Conditions

  • Antibody-mediated Rejection

Interventions

DIAGNOSTIC_TEST

Transcriptome Analysis

Transcriptome Analysis of Formalin Fixed Paraffin Embedded biopsies

Sponsors & Collaborators

  • Thomas Mueller

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-02-15
Primary Completion
2018-03-01
Completion
2018-04-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03430414 on ClinicalTrials.gov