Water and the Gastropressor Response - Tachyphylaxis
NCT00580996 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20
Last updated 2025-10-10
Summary
We are studying the effects of oral water ingestion in patients with orthostatic hypotension. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier.
Conditions
- Orthostatic Hypotension
Interventions
- OTHER
-
water high dose
water 16 oz PO x 1
- OTHER
-
water tiny dose
water 1 oz PO x 1
Sponsors & Collaborators
-
Satish R. Raj
lead OTHER
Principal Investigators
-
Satish R Raj, MD MSCI · Vanderbilt University Medical Center
Study Design
- Allocation
- RANDOMIZED
- Purpose
- OTHER
- Masking
- NONE
- Model
- CROSSOVER
Eligibility
- Min Age
- 18 Years
- Max Age
- 80 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2006-07-31
- Primary Completion
- 2029-12-31
- Completion
- 2029-12-31
Countries
- United States
Study Locations
More Related Trials
-
Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension
NCT01518946 ·Status: COMPLETED ·Phase: PHASE4
-
The Pathophysiology of Orthostatic Hypotension
NCT00748059 ·Status: COMPLETED ·Phase: PHASE1
-
Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
NCT02429557 ·Status: COMPLETED ·Phase: PHASE1
-
Pathophysiology of Orthostatic Intolerance
NCT00608725 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study
NCT02308124 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients
NCT04620382 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)
NCT01000350 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Using Mirabegron to Increase BP in Patients With POTS
NCT06133075 ·Status: COMPLETED ·Phase: PHASE2
-
Clinical Trial for the Prevention of Vasovagal Syncope
NCT00118482 ·Status: COMPLETED ·Phase: PHASE4
-
Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure
NCT02897063 ·Status: RECRUITING ·Phase: PHASE1
-
Local Vasoconstriction in Postural Tachycardia Syndrome
NCT01210430 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride
NCT00426842 ·Status: COMPLETED ·Phase: PHASE2
-
Importance of Liver Innervation for the Osmopressor Response in Humans
NCT01237431 ·Status: COMPLETED ·Phase: NA
-
Effects of Nitroglycerin Versus Labetalol on Tissue Perfusion During Deliberate Hypotension
NCT03809065 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Exercise in OI
NCT00770484 ·Status: COMPLETED ·Phase: NA
-
Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia
NCT05256069 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Hemodynamic Response of Neuropathic And Non-Neuropathic POTS Patients To Adrenoreceptor Agonist And Antagonist
NCT03070730 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS)
NCT06593600 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Droperidol and QTc Interval Changes in ED Patients
NCT06726811 ·Status: RECRUITING
-
A Novel Device for the Treatment of Postural Hypotension - a Signal of Effectiveness Study.
NCT06039410 ·Status: RECRUITING ·Phase: NA
-
Non-Pharmacologic Therapy for Neurocardiogenic Syncope
NCT00096902 ·Status: COMPLETED ·Phase: PHASE2
-
POTS NET mRNA Functional Correlation With NET Activity
NCT03218761 ·Status: ACTIVE_NOT_RECRUITING
-
Analysis of Atropine and Propranolol Induced Changes
NCT00251602 ·Status: COMPLETED ·Phase: PHASE1
-
POTS Adrenergic Ab (CIHR Aims #1&2)
NCT02673996 ·Status: RECRUITING
-
Efficacy and Tolerance of Flucortac in Patients With Orthostatic Neurogenic Hypotension
NCT04128137 ·Status: UNKNOWN ·Phase: PHASE4