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Clinical Applications of High-Frequency Oscillations

NCT00600717 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2026-02-04

No results posted yet for this study

Summary

The objective of this study is to utilize high-frequency brain signals (HFBS) to localize functional brain areas and characterize HFBS in epilepsy, migraine, and other brain disorders. Our goal is to create the world's first high-frequency MEG/EEG/ECoG/SEEG database for the developing brain. HFBS include high-gamma activation/oscillations, high-frequency oscillations (HFOs), ripples, fast ripples, spikelets, fast spikelets, and very high-frequency oscillations (VHFOs). While terminologies and frequency bands may vary among reports, both HFOs and high-gamma waves are crucial for understanding brain function and developing potential treatments for neurological disorders.

We have been developing an intelligent software platform to analyze signals from low to very high-frequency ranges across multiple frequency bands. To achieve these goals, we have developed several innovative techniques and software packages:

* Accumulated spectrogram
* Accumulated source imaging
* Frequency-encoded source imaging
* Multi-frequency analysis at source levels
* Artificial intelligence detection of HFOs
* Neural network analysis (Graph Theory)
* Other techniques (e.g., Independent Component Analysis, virtual sensors) These methods enable researchers to better understand the characteristics and significance of HFOs and high-gamma brain waves, contributing to advancements in the diagnosis and treatment of neurological disorders.

Conditions

Sponsors & Collaborators

  • University of Cincinnati

    collaborator OTHER

  • Children's Hospital Medical Center, Cincinnati

    lead OTHER

Principal Investigators

  • Jing Xiang, Ph.D M.D. · Children's Hospital Medical Center, Cincinnati

Eligibility

Min Age
1 Day
Max Age
69 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2000-11-01
Primary Completion
2027-08-01
Completion
2027-08-01

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00600717 on ClinicalTrials.gov