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Correlation Between the Genetic and Neuroimaging Signatures in Newly Diagnosed Glioblastoma Patients Before Surgery

NCT02590497 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2018-01-31

No results posted yet for this study

Summary

This pilot clinical trial studies the correlation between the genetics and brain images of patients with newly diagnosed glioblastoma before surgery. The genetic characteristics of a tumor are an important way to predict how well it will respond to treatment. Imaging, using magnetic resonance imaging (MRI), takes detailed pictures of organs inside the body, and may also provide information that helps doctors predict how brain tumors will respond to treatment. If MRI can provide doctors with similar information about the tumor as the tumor's genes, it may be able to be used to predict tumor response in patients whose tumors cannot be reached by surgery or biopsy to get tissue samples.

Conditions

Interventions

PROCEDURE

Diffusion Weighted Imaging

Undergo diffusion weighted MRI

DRUG

Gadolinium

Undergo gadolinium-enhanced MRI

OTHER

Laboratory Biomarker Analysis

Tissue genetic analysis

PROCEDURE

Magnetic Resonance Imaging

Undergo gadolinium-enhanced MRI

PROCEDURE

Magnetic Resonance Imaging

Undergo 3D volumetric T1-weighted sequence

PROCEDURE

Magnetic Resonance Imaging

Undergo FLAIR sequence

PROCEDURE

Perfusion Magnetic Resonance Imaging

Undergo perfusion MRI

Sponsors & Collaborators

  • Ohio State University Comprehensive Cancer Center

    lead OTHER

Principal Investigators

  • Pierre Giglio, MD · Ohio State University Comprehensive Cancer Center

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-03-20
Primary Completion
2017-10-26
Completion
2017-10-26

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02590497 on ClinicalTrials.gov