An Initial Study of Lithium in Patients With Medullary Thyroid Cancer
NCT00582712 · Status: TERMINATED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 5
Last updated 2019-12-09
Summary
Primary objective is to evaluate the tumor response rate of patients with MTC treated with Lithium carbonate
Conditions
Interventions
- DRUG
-
Lithium carbonate
Lithium 300mg by mouth, three times daily, escalating to a lithium level of 0.8-1.2; Continue until progressive disease/unacceptable toxicity; Evaluate every 4 weeks.
Sponsors & Collaborators
-
University of Wisconsin, Madison
lead OTHER
Principal Investigators
-
Herbert Chen, MD · University of Wisconsin Cancer Center
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2008-01-31
- Primary Completion
- 2009-05-31
- Completion
- 2012-04-30
Countries
- United States
Study Locations
More Related Trials
-
Pembrolizumab in Recurrent or Metastatic Medullary Thyroid Cancer
NCT03072160 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of OMP-336B11 in Subjects With Locally Advanced or Metastatic Tumors
NCT03295942 ·Status: TERMINATED ·Phase: PHASE1
-
Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART-meso
NCT02580747 ·Status: UNKNOWN ·Phase: PHASE1
-
Phase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants With Pleural Mesotheliomas, or Pleural Effusions From Cancers Expressing Mesothelin
NCT05375825 ·Status: WITHDRAWN ·Phase: PHASE1
-
Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer
NCT00003022 ·Status: COMPLETED ·Phase: PHASE1
-
A Clinical Study of MK-8294 in Participants With Advanced Solid Tumors (MK-8294-001)
NCT07030712 ·Status: RECRUITING ·Phase: PHASE1
-
A First in Man Study of MABp1 in Patients With Advanced Cancers
NCT01021072 ·Status: COMPLETED ·Phase: PHASE1
-
Mesothelin-Targeted Immunotoxin LMB-100 Alone or in Combination With Nab-Paclitaxel in People With Previously Treated Metastatic and/or Locally Advanced Pancreatic Ductal Adenocarcinoma and Mesothelin Expressing Solid Tumors
NCT02810418 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Phase 1 Study of INCMGA00012 in Patients With Advanced Solid Tumors
NCT03059823 ·Status: COMPLETED ·Phase: PHASE1
-
Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic Melanoma
NCT00338377 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
UCLM802 (Anti-Mesothelin CAR-T) Cell Injection in Patients With Mesothelin-positive Advanced Malignant Solid Tumors
NCT05848999 ·Status: UNKNOWN ·Phase: PHASE1
-
Multicenter Phase II Study of IMC-A12 in Patients With Thymoma and Thymic Carcinoma Who Have Been Previously Treated With Chemotherapy
NCT00965250 ·Status: COMPLETED ·Phase: PHASE2
-
Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer
NCT00445965 ·Status: COMPLETED ·Phase: PHASE2
-
Vaccine Therapy in Treating Patients With Metastatic Melanoma
NCT00334776 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of MEDI5395 in Combination With Durvalumab in Participants With Select Advanced Solid Tumors
NCT03889275 ·Status: COMPLETED ·Phase: PHASE1
-
Intradermal Vaccination With Stabilized Tumor mRNA - a Clinical Phase I/II Trial in Melanoma Patients
NCT00204607 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Natural History Study of Children and Adults With Medullary Thyroid Cancer
NCT01660984 ·Status: RECRUITING
-
A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer
NCT06623396 ·Status: RECRUITING ·Phase: PHASE1
-
Vaccine and Chemotherapy for Previously Untreated Metastatic Breast Cancer
NCT00048893 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Mesothelin-targeted CAR T-cell Therapy in Patients With Mesothelioma
NCT04577326 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease
NCT03025256 ·Status: RECRUITING ·Phase: PHASE1
-
Peptide Vaccinations to Treat Patients With Low-Risk Myeloid Cancers
NCT00488592 ·Status: COMPLETED ·Phase: PHASE2
-
Evaluation of a Multi-phosphopeptide Vaccine Plus PolyICLC in Participants With High Risk and Advanced Malignancies
NCT01846143 ·Status: COMPLETED ·Phase: PHASE1
-
Gene-Modified T Cells With or Without Decitabine in Treating Patients With Advanced Malignancies Expressing NY-ESO-1
NCT02650986 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma
NCT06885697 ·Status: RECRUITING ·Phase: PHASE1