Medullary thyroid cancer is a neuroendocrine thyroid malignancy arising from parafollicular C cells that produce calcitonin. It can occur sporadically or as part of inherited syndromes such as MEN2.
Recent studies examine safety profiles of GLP-1 receptor agonists, finding increased risk for nonscarring hair loss but improved survival in patients with brain metastases and type 2 diabetes.
Phase 3 LIBRETTO-432 trial met its primary endpoint, showing selpercatinib delivered statistically significant and clinically meaningful improvement in event-free survival versus placebo as adjuvant therapy in early-stage RET fusion-positive NSCLC.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT06814496 |
Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors |
RECRUITING | PHASE1/PHASE2 |
| NCT06523582 |
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients |
RECRUITING | |
| NCT06292988 |
Predictive Factors for Medullary Thyroid Cancer Aggressiveness |
COMPLETED | |
| NCT06277180 |
68Ga-TCR-FAPI PET/CT Guided Precision Surgery for MTC |
RECRUITING | NA |
| NCT06243965 |
Is Desmoplastic Stromal Reaction Useful to Modulate Lymph Node Dissection in Sporadic Medullary Thyroid Carcinoma? |
COMPLETED | |
| NCT06141369 |
Treatment of Advanced Endocrine Tumor With Iindividualized mRNA Neoantigen Vaccine (mRNA-0523-L001) |
RECRUITING | NA |
| NCT06079723 |
A Detailed Look At What Patients Experience In Medullary Thyroid Cancer Clinical Study |
NOT_YET_RECRUITING | |
| NCT05830500 |
Study of Anlotinib in Patients With Advanced Medullary Thyroid Carcinoma |
RECRUITING | PHASE4 |
| NCT05675605 |
A Study of TY-1091 in Patients With Advanced Solid Tumors |
RECRUITING | PHASE1/PHASE2 |
| NCT05534594 |
Evaluation of the 18F-PSMA Positron Emission Tomography (PET)/CT in Patients With Medullary Thyroid Cancer |
COMPLETED | NA |
