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Evaluation of Potential for Orthostatic Hypotension in Elderly Hypertensives

NCT00508365 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 62

Last updated 2017-08-09

No results posted yet for this study

Summary

This is a multi-center, double-blind, randomized, placebo-controlled, 2-session crossover study to evaluate the incidence of orthostatic hypotension in elderly hypertensive subjects following co-administration of carvedilol CR and lisinopril.

Conditions

Interventions

DRUG

Carvedilol CR capsules

The carvedilol micropump (COREG) CR cpsules will be available with doses of 20 milligrams and 40 milligrams administered orally once daily.

DRUG

Placebo

Placebo capsules to match each dose level will be provided.

DRUG

Lisinopril

Lisinopril will be available as 10 milligrams tablets administered orally once daily.

Sponsors & Collaborators

Principal Investigators

  • GSK Clinical Trials · GlaxoSmithKline

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Model
CROSSOVER

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-09-25
Primary Completion
2008-06-03
Completion
2008-06-03

Countries

  • United States

Study Locations

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Entities

Drugs
Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00508365 on ClinicalTrials.gov