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Presentations of Hyperandrogenic Phenotypes in Taiwanese Women

NCT01940666 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 649

Last updated 2013-11-06

No results posted yet for this study

Summary

STUDY QUESTION: Which of the four abnormally elevated androgen groups (total testosterone \[TT\], androstenedione \[A4\], free androgen index \[FAI\], or dehydroepiandrosterone-sulfate \[DHEA-S\]) present with an unfavorable metabolic and hormonal profile, appear to be more insulin-resistant and pose additional cardiovascular risk? SUMMARY ANSWER: Subjects with excess free androgen index tend to be obese and face the highest metabolic syndrome risk, adipocytokine alterations, insulin resistance (IR) and cardiovascular risk. The excess TT group presents with a marginal IR risk, while the excess A4 group has the highest antimüllerian hormone (AMH), and may counterbalance obesity; this group and the excess DHEA-S group have a favorable association with IR.

Conditions

  • Hyperandrogenism,
  • Polycystic Ovary Syndrome,
  • Metabolic Syndrome,
  • Insulin Resistance,
  • Cardiovascular Disease.

Sponsors & Collaborators

  • Taipei Medical University WanFang Hospital

    lead OTHER

Principal Investigators

  • Ming I Hsu, MD · WanFang Medical Center at Taipei Medical University

Eligibility

Min Age
13 Years
Max Age
48 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-09-30
Primary Completion
2013-03-31
Completion
2013-07-31

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01940666 on ClinicalTrials.gov