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Barrier Function and Production of Inflammatory Cytokines in the Rectal Mucosa in Patients With Septic Shock

NCT00378586 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2009-06-23

No results posted yet for this study

Summary

Life-threatening infection impairs bloodflow to the gut, thereby causing less delivery of oxygen. This leads to increased formation of different inflammatory and infectious markers.

The investigators hypothesize, therefore, that there is a significant difference in the concentrations of inflammatory and infectious markers in the rectal mucosa between patients with septic shock and healthy controls.

Conditions

  • Septic Shock

Interventions

PROCEDURE

Rectal biopsy

Rectal biopsy.

PROCEDURE

Measurement of inflammatory markers in the rectal mucosa

IL-6, TNF-alfa.

PROCEDURE

Measurement of rectal lactic acid

Equilibrium dialysis.

Sponsors & Collaborators

  • Herlev Hospital

    lead OTHER

Principal Investigators

  • Michael Ibsen, MD · Dept. of Intensive Care 4131, Rigshospitalet, Copenhagen, Denmark

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-01-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00378586 on ClinicalTrials.gov