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Mechanisms of Insulin Resistance in Humans

NCT00330967 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2015-04-03

Study results available
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Summary

The Objectives of the study are to: (1)compare the inflammatory response and insulin resistance in skeletal muscles during a systemic infusion of lipid with that during a local infusion of lipid into the femoral artery. which would cause minimal or no systemic hyperlipidemia but local plasma free fatty acid (FFA) concentrations similar to those during the systemic lipid infusion, and (2) determine the inflammatory response and insulin resistance in skeletal muscle during an infusion of lipid into the femoral artery as described above after NF-KB inhibition by high dose salicylate treatment in humans.

Conditions

Interventions

DRUG

20% Intralipid

lipid infusion

Sponsors & Collaborators

Principal Investigators

  • Charles C Oh, MD · Phoenix VA Health Care System Carl T. Hayden VA Medical Center, Phoenix, AZ

Eligibility

Min Age
21 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-04-30
Primary Completion
2012-01-31
Completion
2014-08-31

Countries

  • United States

Study Locations

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Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00330967 on ClinicalTrials.gov