NRx said the FDA issued a positive review letter on its preservative-free ketamine ANDA, requesting only minor administrative changes. The company also received FDA guidance outlining a path to an NDA for NRX-100 using clinical trial data and real-world evidence.
A phase 3 clinical trial has launched for pridopidine as a potential ALS treatment, while AI research identified 18 FDA-approved drugs that may extend survival. Separate studies found a promising three-drug combination for sporadic ALS using new cell models.
A study of over 600,000 patients reveals GLP-1 drugs may reduce addiction across multiple substances, with 50% fewer substance-related deaths and significant reductions in overdoses and hospitalizations. The drugs work by dampening dopamine signaling in brain reward centers. Researchers are exploring broader applications for these medications beyond diabetes and obesity treatment.
Industry leaders highlight advances in AI-enabled trial monitoring, real-world data interoperability, and protocol-driven eSource systems, while emphasizing the need for community engagement in diversity efforts and addressing operational risks in rare disease trials.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07534358 |
Intensive Case Management Between VA and Community Care for Suicide Prevention |
RECRUITING | NA |
| NCT07464834 |
Postcards to Improve Remote Monitoring Connectivity Among Veterans With a Disconnected Monitor |
COMPLETED | NA |
| NCT07296783 |
Transforming Research and Clinical Knowledge in Geriatric Traumatic Brain Injury (TRACK-GERI) |
ENROLLING_BY_INVITATION | |
| NCT07219251 |
Engagement of Veterans With Lung Cancer |
RECRUITING | NA |
| NCT06729606 |
Aviptadil for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial) |
COMPLETED | PHASE3 |
| NCT06729593 |
Remdesivir for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial) |
COMPLETED | PHASE3 |
| NCT06646614 |
Group Advanced Care Planning Pilot for Veterans |
RECRUITING | NA |
| NCT06571513 |
Written Exposure Therapy to Improve Recovery Among Sexual Assault Survivors |
COMPLETED | NA |
| NCT06441617 |
Confirmatory Trial for Alleviating Fatigue in Multiple Sclerosis |
RECRUITING | NA |
| NCT06403514 |
The Effects of a Psychoeducational Intervention on Health and Performance-based Outcomes of Veterans Diagnosed With PTSD |
COMPLETED | NA |
