Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy

Summary

The MAPEC study was designed to investigate whether normalizing the circadian blood pressure profile towards a more dipper pattern (increasing the diurnal/nocturnal ratio of blood pressure) by the use of Chronotherapy (that is, taking into account the time of day of administration of antihypertensive medications) reduces cardiovascular risk.

Conditions

• Hypertension

Interventions

DEVICE

Ambulatory blood pressure monitoring

Sampling at 20-min intervals from 07:00 to 23:00 hours and at 30-min intervals at night for 48 consecutive hours

PROCEDURE

Chronotherapy, timing of antihypertensive medication

Comparison of effects of awakening versus bedtime dosing

DRUG

ACEI (including spirapril, enalapril, quinapril, lisinopril)

Treatment at awakening versus bedtime

DRUG

ARB (including valsartan, telmisartan, olmesartan)

Treatment at awakening versus bedtime

DRUG

beta blockers (including nebivolol, atenolol, carvedilol)

Treatment at awakening versus bedtime

DRUG

diuretics (torasemide, indapamide, HTCZ) and doxazosin

Treatment at awakening versus bedtime

PROCEDURE

Combination therapy in essential hypertension

Treatment at awakening versus bedtime

Sponsors & Collaborators

• Hospital Clinico Universitario de Santiago

  collaborator OTHER

• Ministry of Work and Welfare - Xunta de Galicia

  collaborator OTHER_GOV

• Ministerio de Educacion y Ciencia, Spain

  collaborator UNKNOWN

• University of Vigo

  lead OTHER

Principal Investigators

• Ramon C Hermida, PhD · University of Vigo

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2000-03-31

Primary Completion

2009-04-30

Completion

2009-04-30

Countries

• Spain

Study Locations