Effects of Amlodipine/Benazepril in Reducing Left Ventricular Hypertrophy in Patients With High Risk Hypertension
NCT00139555 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 125
Last updated 2017-02-23
Summary
Left ventricular hypertrophy (LVH) increases the risk of cardiovascular morbidity and mortality in patients with high blood pressure, compared to those without LVH. Reduction of left ventricular mass (LVM) with antihypertensive agents is associated with improved clinical outcome. This study will evaluate the effects of amlodipine/benazepril in reducing LVM in patients with high risk hypertension.
Conditions
- Hypertension
- Left Ventricular Hypertrophy
Interventions
- DRUG
-
amlodipine/benazepril
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Novartis Pharmaceuticals · Novartis Pharmaceuticals
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- DOUBLE
- Model
- PARALLEL
Eligibility
- Min Age
- 55 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2004-07-31
- Primary Completion
- 2006-11-30
- Completion
- 2006-11-30
Countries
- United States
Study Locations
More Related Trials
-
Study of the Efficacy and Safety of LCZ696 Alone and in Combination With Amlodipine in Patients With Hypertension
NCT01865188 ·Status: WITHDRAWN ·Phase: PHASE3
-
Study of Efficacy and Safety of LCZ696/Amlodipine in Grade 1 and 2 Hypertension Patients Uncontrolled by LCZ696 Monotherapy
NCT06236061 ·Status: COMPLETED ·Phase: PHASE3
-
Efficacy and Safety of LCZ696 200 mg + Amlodipine 5 mg in Comparison With Amlodipine 5 mg in Hypertensive Patients Not Responding to Amlodipine
NCT01663233 ·Status: COMPLETED ·Phase: PHASE3
-
Comparision of Blood Pressure Variability Between Amlodipine and Losartan
NCT01964079 ·Status: COMPLETED ·Phase: PHASE4
-
High-Dose Quinapril Versus Low-Dose Quinapril Plus Amlodipine in the Treatment of High-Risk Hypertensive Patients
NCT00313547 ·Status: TERMINATED ·Phase: PHASE4
-
Clinical Trial in Patients With Hypertension and Left Ventricular Dysfunction
NCT02148991 ·Status: COMPLETED
-
Study to Demonstrate the Non-inferiority of Olmesartan Medoxomil Versus Candesartan Cilexetil in Reducing Blood B-type (or Brain) Natriuretic Peptide Levels at Week 24
NCT00679484 ·Status: TERMINATED ·Phase: PHASE3
-
Losartan and HCTZ and Amlodipine vs Atenolol and Amlodipine (0954A-309)(COMPLETED)
NCT00140959 ·Status: COMPLETED ·Phase: PHASE4
-
Benazepril Hydrochloride, Lisinopril, Ramipril, or Losartan Potassium in Treating Hypertension in Patients With Solid Tumors
NCT01234922 ·Status: TERMINATED ·Phase: PHASE2
-
Evaluation of the Metabolic Effects of LCZ696 and Amlodipine in Obese Hypertensive Subjects
NCT01631864 ·Status: COMPLETED ·Phase: PHASE2
-
Comparison Between Losartan and Benazepril in Diabetic Hypertensive Patients Not Controlled by Amlodipine
NCT01603940 ·Status: COMPLETED ·Phase: PHASE4
-
Bedtime Administration of Amlodipine Versus Lisinopril
NCT01835418 ·Status: UNKNOWN ·Phase: NA
-
Amlodipine Diabetic Hypertension Efficacy Response Trial
NCT00159692 ·Status: COMPLETED ·Phase: PHASE4
-
The Vascular Effects of Carvedilol Controlled Release (CR) in Abdominally Obese Hypertensive Patients
NCT00459056 ·Status: COMPLETED ·Phase: PHASE3
-
Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction
NCT01920711 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of the Effects of Eplerenone and Amlodipine on Blood Pressure and Basal Metabolic Rate in Obese Hypertensives
NCT00825188 ·Status: TERMINATED ·Phase: NA
-
Fed Study of Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Lotensin HCT® Tablets 20 mg/25 mg
NCT00649038 ·Status: COMPLETED ·Phase: PHASE1
-
Effect of the Fixed Dose Combination Amlodipine/Valsartan on Central Aortic Blood Pressure in Uncontrolled Essential Hypertension With Amlodipine 5 mg
NCT00687973 ·Status: COMPLETED ·Phase: PHASE4
-
Effects of Aliskiren and Amlodipine on the Renin-Angiotensin System (RAS) and Lipid/Carbohydrate Metabolism in Obese Patients With Hypertension
NCT00498433 ·Status: TERMINATED ·Phase: PHASE2
-
N-of-1 Trials for Blood Pressure Medications in Adults
NCT02744456 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Blood Pressure and Weight Trajectory on a Dual Antihypertensive Combination Plus Sibutramine Versus Placebo in Obese Hypertensives
NCT00679653 ·Status: COMPLETED ·Phase: PHASE3
-
Efficacy of Losartan + Amlodipine Compared to Amlodipine Alone in the Treatment of Uncontrolled High Blood Pressure (MK-0954F-399)
NCT01277822 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy and Safety Study to Evaluate Combination Therapy With Nebivolol and Lisinopril vs. Placebo and Monotherapy in Patients With Stage 2 Diastolic Hypertension
NCT01218100 ·Status: COMPLETED ·Phase: PHASE4
-
Amlodipine as add-on to Olmesartan in Hypertension
NCT00220220 ·Status: COMPLETED ·Phase: PHASE3
-
Sacubitril/Valsartan Versus Amlodipine in Hypertension and Left Ventricular Hypertrophy.
NCT04929600 ·Status: UNKNOWN ·Phase: PHASE4