Gemcitabine in Combination With Either Cisplatin or Carboplatin in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
NCT00112710 · Status: UNKNOWN · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 1350
Last updated 2013-08-26
Summary
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, cisplatin, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known whether giving gemcitabine together with cisplatin is more effective than giving gemcitabine together with carboplatin in treating non-small cell lung cancer.
PURPOSE: This randomized phase III trial is studying gemcitabine and cisplatin to see how well they work compared to gemcitabine and carboplatin in treating patients with stage III or stage IV non-small cell lung cancer.
Conditions
Interventions
- DRUG
- DRUG
- DRUG
-
gemcitabine hydrochloride
Sponsors & Collaborators
-
University Hospital Birmingham
lead OTHER
Principal Investigators
-
Hugh Jarrett · Institute of Clinical Research - Birmingham
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2005-03-31
Countries
- United Kingdom
Study Locations
More Related Trials
-
Gemcitabine/Platinum Containing Regimens as Preoperative Chemotherapy for Patients With Non Small Cell Lung Cancer
NCT00191230 ·Status: COMPLETED ·Phase: PHASE2
-
Gemcitabine, Cisplatin, and Gefitinib in Treating Patients Who Are Undergoing Surgery for Stage III Non-Small Cell Lung Cancer
NCT00103051 ·Status: COMPLETED ·Phase: PHASE2
-
Gemcitabine Plus Radiation Therapy or Combination Chemotherapy in Treating Patients With Non-small Cell Lung Cancer
NCT00003202 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study With Gemcitabine, Cisplatin, and LY293111 in Non-Small Cell Lung Cancer
NCT00069875 ·Status: COMPLETED ·Phase: PHASE2
-
Gemcitabine/Oxaliplatin (GEMOX) vs Carboplatin/Paclitaxel (CP) in Non-Small Cell Lung Cancer (NSCLC)
NCT00087802 ·Status: COMPLETED ·Phase: PHASE3
-
Carboplatin and Gemcitabine in Treating Patients With Advanced Solid Tumors
NCT00021346 ·Status: COMPLETED ·Phase: PHASE1
-
Randomized Trial of Gemcitabine/Cisplatin + PF-3512676 vs Gemcitabine/Cisplatin Alone in Patients With Advanced NSCLC
NCT00254904 ·Status: TERMINATED ·Phase: PHASE3
-
G-Step: Gemcitabine Based Small-cell Lung Cancer Treatment in Elderly Patients
NCT00401609 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Trial Comparing 3 and 4 Week Regimen of Gemcitabine and Cisplatin in Patients With Lung Cancer
NCT00489996 ·Status: COMPLETED ·Phase: PHASE2
-
Adjuvant Gemcitabine Plus Oxaliplatin Versus Gemcitabine Plus Cisplatin for Completely Resected Stage IB/II/IIIA NSCLC
NCT00452881 ·Status: UNKNOWN ·Phase: PHASE2
-
Gemcitabine and Oxaliplatin as Second-Line Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
NCT00305786 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase III Randomized, Double-blind, Placebo Controlled Trial Comparing the Efficacy of Gemcitabine, Cisplatin and Sorafenib to Gemcitabine, Cisplatin and Placebo in First-Line Treatment of Patients With Stage IIIb With Effusion and Stage IV Non-Small Cell Lung Cancer (NSCLC)
NCT00449033 ·Status: COMPLETED ·Phase: PHASE3
-
Evaluation of Carboplatin Plus Gemcitabine Followed by Concomitant Chemoradiation for Non-resectable Stage III NSCLC
NCT00463515 ·Status: COMPLETED ·Phase: PHASE2
-
Gemcitabine Plus Cisplatin Versus Gemcitabine Plus Paclitaxel in Triple Negative Breast Cancer (TNBC)
NCT01287624 ·Status: COMPLETED ·Phase: PHASE3
-
The PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer
NCT06115499 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2/PHASE3
-
Study Of The Effect Of CP-751,871 In Combination With Gemcitabine And Cisplatin In Patients With Advanced Non-Small Cell Lung Cancer
NCT00907504 ·Status: WITHDRAWN ·Phase: PHASE3
-
Alimta and Gemcitabine in Non-Small Cell Lung Cancer
NCT00434135 ·Status: COMPLETED ·Phase: PHASE2
-
Clinical Trial of Gemcitabine and Oxaliplatin in Recurrent or Metastatic Breast Cancer
NCT00159458 ·Status: TERMINATED ·Phase: PHASE2
-
Oxaliplatin and Gemcitabine in Treating Patients With Advanced Cancer
NCT00004220 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy Study of GEMOX Combination and Vinorelbine in NSCL Patients
NCT00271271 ·Status: COMPLETED ·Phase: PHASE2
-
A Randomized Phase 3 Trial of Pemetrexed and Cisplatin Versus Gemcitabine and Cisplatin in Patients With Locally Advanced or Metastatic Non Small Cell Lung Cancer
NCT00087711 ·Status: COMPLETED ·Phase: PHASE3
-
Gemcitabine Hydrochloride or Pemetrexed Disodium and Carboplatin With or Without Celecoxib in Treating Patients With Advanced Non-Small Cell Lung Cancer
NCT01041781 ·Status: TERMINATED ·Phase: PHASE3
-
Gemcitabine Plus Cisplatin Versus Gemcitabine Plus Carboplatin in Triple Negative Breast Cancer (TNBC)
NCT02341911 ·Status: UNKNOWN ·Phase: PHASE2
-
Gemcitabine and Oxaliplatin in Treating Patients With Metastatic Cancer
NCT00274859 ·Status: UNKNOWN ·Phase: PHASE2
-
Gemcitabine in Treating Patients With Recurrent or Refractory Bladder Cancer
NCT00014287 ·Status: WITHDRAWN ·Phase: PHASE1