Motexafin Gadolinium and Doxorubicin in Treating Patients With Advanced Cancer
NCT00036790 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL
Last updated 2019-12-17
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Motexafin gadolinium may increase the effectiveness of doxorubicin by making tumor cells more sensitive to the drug.
PURPOSE: Phase I trial to study the effectiveness of combining motexafin gadolinium with doxorubicin in treating patients who have recurrent or metastatic cancer.
Conditions
- Breast Cancer
- Chronic Myeloproliferative Disorders
- Colorectal Cancer
- Head and Neck Cancer
- Leukemia
- Lung Cancer
- Lymphoma
- Multiple Myeloma and Plasma Cell Neoplasm
- Myelodysplastic/Myeloproliferative Diseases
- Prostate Cancer
- Small Intestine Cancer
- Unspecified Adult Solid Tumor, Protocol Specific
Interventions
- DRUG
-
doxorubicin hydrochloride
- DRUG
-
motexafin gadolinium
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
University of Wisconsin, Madison
lead OTHER
Principal Investigators
-
Markus Renschler, MD · Pharmacyclics LLC.
Study Design
- Purpose
- TREATMENT
Eligibility
- Min Age
- 18 Years
- Max Age
- 120 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2002-02-28
- Primary Completion
- 2005-10-31
Countries
- United States
Study Locations
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