Chemotherapy Plus Bone Marrow Transplantation in Treating Patients With Refractory Non-Hodgkin's Lymphoma, Hodgkin's Disease, or Multiple Myeloma

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining bone marrow transplantation with chemotherapy may allow doctors to give higher doses of chemotherapy and kill more tumor cells.

PURPOSE: This phase II trial is studying the side effects of giving a bone marrow transplant together with chemotherapy and to see how well it works in treating patients with refractory non-Hodgkin's lymphoma, Hodgkin's lymphoma, or multiple myeloma.

Conditions

• Lymphoma
• Multiple Myeloma and Plasma Cell Neoplasm

Interventions

BIOLOGICAL

filgrastim

BIOLOGICAL

sargramostim

DRUG

carmustine

DRUG

cyclophosphamide

DRUG

cytarabine

DRUG

etoposide

DRUG

leucovorin calcium

DRUG

methotrexate

DRUG

perfosfamide

DRUG

therapeutic hydrocortisone

PROCEDURE

allogeneic bone marrow transplantation

PROCEDURE

autologous bone marrow transplantation

PROCEDURE

in vitro-treated bone marrow transplantation

PROCEDURE

peripheral blood stem cell transplantation

PROCEDURE

syngeneic bone marrow transplantation

RADIATION

radiation therapy

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• Barbara Ann Karmanos Cancer Institute

  lead OTHER

Principal Investigators

• Roger Dansey, MD · Barbara Ann Karmanos Cancer Institute

Study Design

Purpose

TREATMENT

Eligibility

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1993-10-31

Primary Completion

2001-09-30

Completion

2003-10-31

Countries

• United States

Study Locations