Also known as: meth
Methamphetamine is a central nervous system stimulant with prescription and nonmedical use contexts. In the United States, prescription products containing methamphetamine are marketed (e.g., Desoxyn) for limited clinical indications. It also has high abuse/addiction risk in nonmedical settings.
Drug-soaked paper has become the most commonly found drug in Ohio prisons and was tied to at least 13 fatal K2 overdoses in 2024. Convictions in the state’s largest prison drug conspiracy case detailed how the paper was smuggled and sold.
Police in Karachi, Kentucky and Indiana arrested three suspects in separate drug investigations involving alleged trafficking in Ice, methamphetamine and cocaine. One case involved a controlled purchase, while another led to the seizure of nearly 60 grams of cocaine and a firearm.
Cychlorphine has been detected in central Kentucky as Tennessee authorities link the synthetic opioid to 41 deaths in 11 counties in 2026. The drug is believed to be 10 times more potent than fentanyl and is not detectable by fentanyl testing strips.
New Zealand police arrested 11 people and seized drugs, cash, and firearms after uncovering a dark web drug import network, while Canadian police made a separate bust seizing cocaine, fentanyl, and methamphetamine. The New Zealand operation involved international cooperation and intercepted over 200kg of drugs at borders. The busts come as New Zealand data shows record-breaking cocaine consumption nationwide.
A months-long drug investigation in North Carolina led to four arrests and over 70 felony charges, with seizures including firearms and 120 grams of cocaine and methamphetamine. Separately, a traffic stop revealed cocaine, marijuana, and a firearm, highlighting ongoing regional drug activity. Law enforcement officials note challenges from differing state marijuana laws and increasing drug-related incidents.
Delaware State Police arrested a North Carolina man and seized 2.3 kilograms of cocaine during a traffic stop on I-95. The suspect faces multiple felony drug charges and is being held on $120,801 cash bond. Separate drug investigations in West Virginia and Ohio also resulted in arrests and seizures of fentanyl, methamphetamine, firearms, and child pornography.
DEA and New York authorities seized over 8,800 counterfeit fentanyl pills and 891 grams of cocaine in Brooklyn, arresting one suspect. In a separate operation, agents recovered 20 pounds of methamphetamine and $50,000 in cash. The busts are part of efforts to disrupt synthetic drug shipments into New York City.
U.S. overdose deaths declined 19% year-over-year to 72,108 for the 12 months ending September 2025, but the drug market is evolving with dangerous polydrug cocktails like "pink cocaine" and "rhino tranq" that are harder to detect and reverse. These synthetic blends combine fentanyl with stimulants, sedatives, and veterinary tranquilizers, creating new public health challenges as naloxone becomes less effective against complex overdoses.
U.S. Immigration and Customs Enforcement arrested multiple criminal illegal aliens convicted of serious crimes including child sex offenses, murder, sexual assault, and drug trafficking. Nearly 70% of arrests involve individuals with pending criminal charges or prior convictions in the United States.
British Columbia recorded 1,826 unregulated drug toxicity deaths in 2025, a 21% decrease from 2024. New research links the decline to decreasing fentanyl concentrations in the illicit drug supply, though nearly five people continue to die daily.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT06989853 |
Methamphetamine and Troriluzole |
RECRUITING | EARLY_PHASE1 |
| NCT06721494 |
A Single-Dose Study to Evaluate Safety and Efficacy of CS-1103 in Participants Receiving a Single Dose of Methamphetamine |
RECRUITING | PHASE2 |
| NCT05783817 |
MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study) |
RECRUITING | PHASE2 |
| NCT05379959 |
Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function |
COMPLETED | EARLY_PHASE1 |
| NCT05003076 |
Brain Function and EEG |
COMPLETED | EARLY_PHASE1 |
| NCT04642820 |
Drugs Brain and Behavior (DDP) |
COMPLETED | EARLY_PHASE1 |
| NCT04614584 |
Mirtazapine and Methamphetamine Drug-drug Interaction Study |
COMPLETED | PHASE1 |
| NCT04178993 |
Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine] |
COMPLETED | PHASE1 |
| NCT03790618 |
Effect of Stimulant Drugs on Social Perception |
COMPLETED | PHASE1 |
| NCT03106571 |
Study of Pomaglumetad and Methamphetamine |
TERMINATED | PHASE1 |
