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S1R Imaging-Based Cryoneurolysis in Chronic Pain

NCT07768501 · Status: NOT_YET_RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 6

Last updated 2026-08-17

No results posted yet for this study

Summary

The goal of this clinical trial is to determine whether a sigma-1 receptor PET/MRI scan can help identify the specific nerves responsible for chronic pain.

Researchers will use an investigational imaging agent called \[18F\]FTC-146 to look for signs of pain generating nerve irritation or injury that may not be visible on convention imaging tests.

Participants whose pain-generating nerve can be identified may undergo a diagnostic nerve block and, if successful, a standard clinical procedure called cryoneurolysis will be used to temporarily interrupt pain signals.

Conditions

Interventions

DRUG

[18F]-FTC-146

Participants will receive a single intravenous injection of up to 5-10 mCi of \[18F\] FTC-146 inside the PET/MRI scanner. They will undergo up to three (3) whole-body PET/MRI scans with possible additional focused scan of the painful area within 180 minutes post- injection.

Sponsors & Collaborators

  • Society of Interventional Radiology Foundation

    collaborator OTHER

  • Davidzon, Guido, M.D.

    lead OTHER

Principal Investigators

  • Lynne N Martin, MD · Stanford School of Medicine, Radiology

  • Kip E Guja, MD, PhD · Stanford School of Medicine, Radiology

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-09-30
Primary Completion
2029-09-30
Completion
2030-09-30
FDA Drug
Yes

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07768501 on ClinicalTrials.gov