Clinical Trials

NCT05220917 | ACTIVE_NOT_RECRUITING

781430 participants

Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-13

Start Date:

2021-08-01

Completion:

2026-05-31

Conditions

• Cardiovascular Events
• Type2 Diabetes
• Renal Disease

Interventions

• DRUG

No Results Yet

NCT05219695 | RECRUITING | PHASE1

82 participants

Medical Imaging and Focused Ultrasound Treatment for Breast Tumors Using Harmonic Motion Imaging (HMI)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-01-19

Completion:

2031-05-31

Conditions

• Fibroadenoma
• Breast Cancer Stage I

Interventions

• PROCEDURE
• DRUG

No Results Yet

NCT05211323 | ACTIVE_NOT_RECRUITING | PHASE2

4 participants

A Study to Determine Whether Chemotherapy and Atezolizumab is Better Than Chemotherapy, Bevacizumab and Atezolizumab in Patients With Advanced Liver Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-12-07

Completion:

2026-01-20

Conditions

• Combined Hepatocellular Carcinoma and Cholangiocarcinoma
• Stage III Liver Cancer
• Stage IV Liver Cancer

Interventions

• BIOLOGICAL
• PROCEDURE
• DRUG

No Results Yet

NCT05206955 | RECRUITING | PHASE3

42 participants

Study of Tadalafil vs. Placebo for Improving Hemodynamics and End-Organ Dysfunction in Fontan Physiology

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-09-16

Completion:

2026-11-30

Conditions

• Fontan Palliation

Interventions

• DRUG

No Results Yet

NCT05206422 | COMPLETED | NA

21 participants

DORAYA-HF Early Feasibility Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-10-05

Completion:

2026-01-31

Conditions

• Acute Decompensated Heart Failure

Interventions

• DEVICE

No Results Yet

NCT05205382 | COMPLETED | NA

116 participants

Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-04-01

Completion:

2025-04-15

Conditions

• Electronic Cigarette Use

Interventions

• OTHER

Results Available

NCT05204927 | ACTIVE_NOT_RECRUITING | PHASE3

439 participants

177Lu-PSMA-I&T for Metastatic Castration-Resistant Prostate Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-02-14

Completion:

2024-08-02

Conditions

• Metastasis From Malignant Tumor of Prostate

Interventions

• DRUG

No Results Yet

NCT05203614 | COMPLETED | NA

60 participants

Positive Activities for Asian American Cancer Patients and Caregivers

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2021-11-30

Completion:

2024-11-19

Conditions

• Cancer

Interventions

• BEHAVIORAL

Results Available

NCT05198830 | RECRUITING | PHASE2

42 participants

Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-12-15

Completion:

2027-06-30

Conditions

• Lung Adenocarcinoma
• Lung Large Cell Carcinoma
• Lung Non-Squamous Non-Small Cell Carcinoma
• Stage III Lung Cancer AJCC v8

Interventions

• DRUG
• PROCEDURE
• BIOLOGICAL
• RADIATION

No Results Yet

NCT05198284 | ACTIVE_NOT_RECRUITING

2000 participants

Prospective Decision Impact Clinical Utility Trial of KidneyIntelX

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-13

Start Date:

2021-11-01

Completion:

2023-12-01

Conditions

• Diabetic Kidney Disease
• Chronic Kidney Diseases
• Chronic Kidney Disease Stage 1
• Chronic Kidney Disease Stage 2
• Chronic Kidney Disease Stage 3

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05178420 | COMPLETED | NA

1880 participants

STREAM Trial - Statins in Multimorbid Older Adults Without Cardiovascular Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2021-11-16

Completion:

2026-04-30

Conditions

• Statin Treatment for Primary Prevention

Interventions

• OTHER

No Results Yet

NCT05176639 | COMPLETED | PHASE3

113 participants

A Safety, Tolerability, and Efficacy Study of Veligrotug (VRDN 001) in Participants With Thyroid Eye Disease (TED)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-11-16

Completion:

2024-07-15

Conditions

• Thyroid Eye Disease

Interventions

• DRUG

Results Available

NCT05155033 | RECRUITING | PHASE2

78 participants

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-08-18

Completion:

2031-09-01

Conditions

• Metastatic Melanoma
• Advanced Locoregional Melanoma
• Metastatic Renal Cell Carcinoma
• Clear Cell Histology

Interventions

• DRUG

No Results Yet

NCT05142683 | RECRUITING | NA

300 participants

Effectiveness of an Integrated Care Pathway for Depression: Cluster Randomized Controlled Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-02-01

Completion:

2027-09-30

Conditions

• Major Depressive Disorder

Interventions

• OTHER

No Results Yet

NCT05136196 | RECRUITING | PHASE2

150 participants

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-12-06

Completion:

2027-01-01

Conditions

• Clinical Stage III Cutaneous Melanoma AJCC v8
• Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
• Clinical Stage IV Cutaneous Melanoma AJCC v8
• Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
• Locally Recurrent Head and Neck Squamous Cell Carcinoma
• Locally Recurrent Hypopharyngeal Squamous Cell Carcinoma
• Locally Recurrent Laryngeal Squamous Cell Carcinoma
• Locally Recurrent Oral Cavity Squamous Cell Carcinoma
• Locally Recurrent Oropharyngeal Squamous Cell Carcinoma
• Metastatic Head and Neck Squamous Cell Carcinoma
• Metastatic Hypopharyngeal Squamous Cell Carcinoma
• Metastatic Laryngeal Squamous Cell Carcinoma
• Metastatic Melanoma
• Metastatic Oral Cavity Squamous Cell Carcinoma
• Metastatic Oropharyngeal Squamous Cell Carcinoma
• Recurrent Melanoma
• Stage III Hypopharyngeal Carcinoma AJCC v8
• Stage III Laryngeal Cancer AJCC v8
• Stage III Lip and Oral Cavity Cancer AJCC v8
• Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8
• Stage IV Hypopharyngeal Carcinoma AJCC v8
• Stage IV Laryngeal Cancer AJCC v8
• Stage IV Lip and Oral Cavity Cancer AJCC v8
• Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
• Unresectable Melanoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT05135559 | ACTIVE_NOT_RECRUITING | PHASE3

153 participants

A Research Study on How Well Concizumab Works for You if You Have Haemophilia A or B With or Without Inhibitors

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-03-24

Completion:

2026-04-21

Conditions

• Haemophilia A and B With and Without Inhibitors

Interventions

• DRUG

No Results Yet

NCT05135533 | COMPLETED | NA

53 participants

Neuromodulation and Dynamic Balance in Stroke

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2023-08-28

Completion:

2025-07-24

Conditions

• Stroke

Interventions

• DEVICE
• OTHER

Results Available

NCT05124392 | RECRUITING

150 participants

OBSERVE: Biomarkers in Individuals at Risk for Prion Disease

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-13

Start Date:

2017-12-01

Completion:

2027-06-01

Conditions

• CJD (Creutzfeldt Jakob Disease)
• Prion Diseases
• GSS
• FFI
• Familial Fatal Insomnia

No Results Yet

NCT05115344 | WITHDRAWN | PHASE1

0 participants

Study of Flonoltinib Maleate Tablets in the Treatment of Proliferative Bone Marrow Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2021-11-12

Completion:

2022-12-29

Conditions

• Myeloproliferative Neoplasm (MPN)
• Myelofibrosis，MF

Interventions

• DRUG

No Results Yet

NCT05099003 | RECRUITING | PHASE1/PHASE2

132 participants

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-05-31

Completion:

2027-06-30

Conditions

• Malignant Glioma

Interventions

• PROCEDURE
• RADIATION
• DRUG

No Results Yet

NCT05086250 | COMPLETED | EARLY_PHASE1

12 participants

Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-10-20

Completion:

2026-03-06

Conditions

• Anxiety
• Pancreatic Cancer

Interventions

• DRUG

No Results Yet

NCT05067634 | ACTIVE_NOT_RECRUITING | PHASE3

140 participants

Safety and Efficacy Study of Cenobamate in Pediatric Subjects 2-17 Years of Age With Partial-onset (Focal) Seizures

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-01-14

Completion:

2026-11-30

Conditions

• Partial Epilepsy

Interventions

• DRUG

No Results Yet

NCT05064319 | COMPLETED | PHASE2

51 participants

Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-02-24

Completion:

2026-07-31

Conditions

• Bipolar Disorder
• Cannabis Use
• Schizoaffective Disorder, Bipolar Type
• Bipolar I Disorder
• Bipolar II Disorder
• Cannabis Use Disorder, Mild
• Cannabis Use Disorder, Moderate
• Cannabis Use Disorder, Severe

Interventions

• DRUG

No Results Yet

NCT05052216 | RECRUITING

120 participants

Development of a Wearable Point of Care Monitoring Device for Pediatric Obstructive Sleep Apnea

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-13

Start Date:

2022-08-25

Completion:

2028-01-31

Conditions

• Pediatric Obstructive Sleep Apnea

No Results Yet

NCT05009329 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

315 participants

A Study of JAB-21822 in Adult Patients With Advanced Solid Tumors Harboring KRAS p.G12C Mutation in China

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2021-07-26

Completion:

2026-08-31

Conditions

• NSCLC
• Solid Tumor

Interventions

• DRUG

No Results Yet

NCT05001880 | RECRUITING | PHASE2

66 participants

Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-03-22

Completion:

2027-08-01

Conditions

• Peritoneal Malignant Mesothelioma

Interventions

• BIOLOGICAL
• PROCEDURE
• DRUG

No Results Yet

NCT04960514 | ACTIVE_NOT_RECRUITING

2000 participants

Prospective Decision Impact Trial of KidneyIntelX

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-13

Start Date:

2021-11-22

Completion:

2023-12-01

Conditions

• Diabetic Kidney Disease
• Chronic Kidney Disease Stage 1
• Chronic Kidney Disease Stage 2
• Chronic Kidney Disease, Stage 3 (Moderate)

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT04945707 | ACTIVE_NOT_RECRUITING | PHASE4

65 participants

Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2021-11-26

Completion:

2026-06-25

Conditions

• Iron-deficiency
• Heart Failure With Preserved Ejection Fraction

Interventions

• DRUG

No Results Yet

NCT04944940 | RECRUITING

70 participants

Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-13

Start Date:

2021-10-25

Completion:

2026-12-30

Conditions

• Spinal and Bulbar Muscular Atrophy
• Kennedys Disease
• Motor Neuron Disease

No Results Yet

NCT04943497 | COMPLETED

2390 participants

A Prospective Observational Study to Describe Clinical Outcomes, Treatment Patterns, Patients Characteristics Among Patients With HR+/HER2- Advanced BC Initiating Treatment With Risarg®, Piqray®, Endocrine Therapy or Chemotherapy in Routine Clinical Practice in Russia

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-13

Start Date:

2021-07-27

Completion:

2025-07-28

Conditions

• Breast Cancer

Interventions

• OTHER

No Results Yet

NCT04940507 | ACTIVE_NOT_RECRUITING | NA

50 participants

BRAINFUL (BRAIN Tumor Focused Ultrasound-enabled Liquid Biopsy) Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2021-06-10

Completion:

2026-12-31

Conditions

• Brain Neoplasms
• Liquid Biopsy

Interventions

• PROCEDURE

No Results Yet

NCT04933539 | ACTIVE_NOT_RECRUITING | PHASE2

14 participants

Subcutaneous Daratumumab, Once Weekly Carfilzomib, and Dexamethasone (DKd) in Patients With High-Risk Smoldering Multiple Myeloma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-10-31

Completion:

2026-08-31

Conditions

• Multiple Myeloma

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04930653 | SUSPENDED | PHASE2

34 participants

Extracorporeal Photopheresis and Mogamulizumab for the Treatment of Erythrodermic Cutaneous T Cell Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2022-10-19

Completion:

2028-06-15

Conditions

• Folliculotropic Mycosis Fungoides
• Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
• Sezary Syndrome
• Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v8
• Stage II Mycosis Fungoides and Sezary Syndrome AJCC v8
• Stage IIA Mycosis Fungoides and Sezary Syndrome AJCC v8
• Stage IIB Mycosis Fungoides and Sezary Syndrome AJCC v8
• Transformed Mycosis Fungoides

Interventions

• PROCEDURE
• BIOLOGICAL
• OTHER

No Results Yet

NCT04926922 | COMPLETED

200 participants

PREVAIL VIIIa: Evaluation of Latent Tuberculosis Infection Screening Methods in People Living With Retroviral Infection in Liberia

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-13

Start Date:

2021-07-27

Completion:

2026-04-30

Conditions

• Tuberculosis
• HIV

No Results Yet

NCT04924101 | COMPLETED | PHASE2

122 participants

Efficacy and Safety of Pembrolizumab Plus Investigational Agents in Combination With Chemotherapy as First-Line Treatment in Extensive-Stage Small Cell Lung Cancer (ES-SCLC) (MK-3475-B99/ KEYNOTE-B99)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2021-07-15

Completion:

2025-06-23

Conditions

• Small Cell Lung Cancer

Interventions

• BIOLOGICAL
• DRUG

Results Available

NCT04912739 | RECRUITING

18000 participants

Targeted Health Dialogues in Primary Care

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-13

Start Date:

2020-10-01

Completion:

2030-12-31

Conditions

• Health Behaviors
• Risk Factors
• Cardiovascular Diseases
• Cancer
• Serious Diseases

Interventions

• BEHAVIORAL

No Results Yet

NCT04910269 | TERMINATED | PHASE3

741 participants

Outpatient Treatment With Anti-Coronavirus Immunoglobulin

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2021-08-06

Completion:

2026-05-24

Conditions

• COVID
• SARS-CoV2 Infection
• Covid19

Interventions

• BIOLOGICAL
• OTHER

No Results Yet

NCT04888936 | RECRUITING

500 participants

Clinical, Genetic, and Epidemiologic Study of Children and Adults With RASopathies

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-13

Start Date:

2022-04-25

Completion:

2031-01-31

Conditions

• Costello Syndrome
• Noonan Syndrome
• Cardiofaciocutaneous Syndrome
• Legius Syndrome
• Capillary Arteriovenous Malformation Syndrome
• RASopathy

No Results Yet

NCT04853342 | RECRUITING | PHASE3

318 participants

To Assess the Efficacy and Safety of Furmonertinib Versus Placebo, in Patients With Epidermal Growth Factor Receptor Mutation Positive Stage II-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2021-06-07

Completion:

2026-12-31

Conditions

• Non-small Cell Lung Carcinoma

Interventions

• DRUG

No Results Yet

NCT04828096 | ACTIVE_NOT_RECRUITING | NA

324 participants

Retention With Three Different Bonded Retainers a Multicenter, Randomized Controlled Trial With 5-year Follow-up

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-13

Start Date:

2021-03-25

Completion:

2030-09-30

Conditions

• Dental Malocclusion
• Stability

Interventions

• OTHER

No Results Yet