Clinical Trials

NCT06188520 | RECRUITING | PHASE1/PHASE2

564 participants

A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-12-05
Completion:: 2027-08-04

Conditions

ER+ HER2- Advanced Breast Cancer
High-grade Serous Ovarian Cancer (HGSOC)

Interventions

DRUG

No Results Yet

NCT06176261 | RECRUITING | PHASE2

58 participants

DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-01-08
Completion:: 2028-01-01

Conditions

Breast Cancer
Breast Cancer Female
Metastatic Triple-Negative Breast Carcinoma
ER Positive Breast Cancer
HER2-negative Breast Cancer
HER2 Negative Breast Carcinoma
ER-negative Breast Cancer

Interventions

DRUG

No Results Yet

NCT06168812 | ACTIVE_NOT_RECRUITING | PHASE2

29 participants

A Study of Glipizide to Treat High Blood Sugar in People With Pancreatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-12-05
Completion:: 2026-12-05

Conditions

Pancreatic Cancer
Pancreatic Carcinoma
Pancreatic Ductal Adenocarcinoma
Pancreatic Cancer Metastatic
Metastatic Pancreatic Cancer
Metastatic Pancreatic Ductal Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT06168409 | COMPLETED | PHASE3

218 participants

A Study to Investigate the Effect of Baxdrostat on Ambulatory Blood Pressure in Participants With Resistant Hypertension

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-03-01
Completion:: 2025-08-17

Conditions

Resistant Hypertension

Interventions

DRUG

Results Available

NCT06162728 | COMPLETED | PHASE1/PHASE2

87 participants

Dose Escalation Trial Of Safety, Pharmacokinetic/Pharmacodynamic And Preliminary Clinical Activity of Briquilimab In Adult Patients With Chronic Spontaneous Urticaria (CSU)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-11-29
Completion:: 2026-07-08

Conditions

Chronic Spontaneous Urticaria

Interventions

DRUG
OTHER

No Results Yet

NCT06157671 | ENROLLING_BY_INVITATION

1000 participants

The LINFU® U.S. Registry for the Detection of Asymptomatic Pancreatic Ductal Adenocarcinoma

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-01-31
Completion:: 2030-01-01

Conditions

Pancreatic Adenocarcinoma
Pancreatic Intraepithelial Neoplasia

No Results Yet

NCT06150729 | COMPLETED

107 participants

Study of Intramuscular Injections of OnabotulinumtoxinA to Assess Change in Disease Activity in Pediatric Participants With Spasticity Associated With Cerebral Palsy

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-09-08
Completion:: 2025-05-30

Conditions

Spasticity

No Results Yet

NCT06147843 | RECRUITING | NA

1000 participants

French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-09-17
Completion:: 2027-09-30

Conditions

Amyotrophic Lateral Sclerosis

Interventions

OTHER

No Results Yet

NCT06145633 | RECRUITING | PHASE2

15 participants

Vorinostat and 177Lu-PSMA-617 for the Treatment of PSMA-Low Metastatic Castration-Resistant Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-09-18
Completion:: 2026-12-30

Conditions

Castration-Resistant Prostate Carcinoma
Metastatic Prostate Adenocarcinoma
Stage IVB Prostate Cancer AJCC v8

Interventions

PROCEDURE
OTHER
DRUG

No Results Yet

NCT06144749 | COMPLETED | PHASE2

13 participants

A Safety, Efficacy, and Pharmacokinetic (PK) Study of HBI-002, an Oral Carbon Monoxide (CO) Therapeutic, in Subjects With Sickle Cell Disease (SCD)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2025-02-15
Completion:: 2026-06-30

Conditions

Anemia, Sickle Cell

Interventions

DRUG

No Results Yet

NCT06143956 | RECRUITING | PHASE2

1481 participants

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-11-17
Completion:: 2027-09-30

Conditions

Obesity
Overweight

Interventions

DRUG

No Results Yet

NCT06131554 | COMPLETED | PHASE3

1480 participants

A Clinical Trial to Evaluate the Immunogenicity and Safety of Group ACYW135 Meningococcal Conjugate Vaccine (CRM197) in Adults Aged 18 to 55 Years

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-03-20
Completion:: 2024-07-12

Conditions

Meningococcal Meningitis

Interventions

BIOLOGICAL

No Results Yet

NCT06129864 | RECRUITING | PHASE3

1145 participants

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-12-14
Completion:: 2030-04-17

Conditions

Locally Advanced Head and Neck Squamous Cell Carcinoma

Interventions

DRUG

No Results Yet

NCT06129747 | RECRUITING | PHASE2

55 participants

Repeat Breast Conserving Surgery Followed by Daily Partial Breast Irradiation in Ipsilateral Breast

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-11-30
Completion:: 2029-08-09

Conditions

Breast Cancer
Tumor, Breast

Interventions

RADIATION

No Results Yet

NCT06113939 | NOT_YET_RECRUITING | PHASE4

60 participants

Prevention of Infection of the Respiratory Tract Through Application of Non-Invasive Methods of Secretion Suctioning

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2026-09-15
Completion:: 2028-12-30

Conditions

Intubation Complication
Stroke, Ischemic
Stroke Hemorrhagic
Head Trauma
Cardiac Arrest
Ventilator Associated Pneumonia
Airway Clearance Impairment

Interventions

DEVICE
DRUG

No Results Yet

NCT06112743 | ACTIVE_NOT_RECRUITING | PHASE4

63 participants

A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-01-24
Completion:: 2026-07-16

Conditions

Cardiomyopathy, Hypertrophic

Interventions

DRUG

No Results Yet

NCT06106373 | COMPLETED | NA

20 participants

iotaSOFT Pediatric Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2022-05-17
Completion:: 2024-10-24

Conditions

Hearing Loss, Sensorineural
Hearing Loss, Bilateral
Hearing Loss, Unilateral

Interventions

DEVICE

Results Available

NCT06099288 | RECRUITING | NA

257 participants

Strong Families Start at Home/Familias Fuertes Comienzan en Casa

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-01-01
Completion:: 2027-11-01

Conditions

Metabolic Syndrome, Protection Against
Diet, Healthy

Interventions

BEHAVIORAL

No Results Yet

NCT06092476 | ACTIVE_NOT_RECRUITING | NA

18 participants

Trial to Evaluate Efficacy+Safety of Revita DMR Treatment Paradigm 1 and Retreatment in Type 2 Diabetes Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-08-09
Completion:: 2027-03-01

Conditions

Diabetes Mellitus, Type 2

Interventions

DEVICE
OTHER

No Results Yet

NCT06090864 | RECRUITING | PHASE1/PHASE2

31 participants

ATLCAR.CD30.CCR4 for CD30+ HL ATLCAR.CD30.CCR4 Cells

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-04-25
Completion:: 2028-08-03

Conditions

Hodgkin Lymphoma
Relapse
Refractory

Interventions

DRUG
BIOLOGICAL

No Results Yet

NCT06085781 | RECRUITING | NA

60 participants

A Study of Head and Neck MRI and Tumor Microenvironment Biomarkers

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-01-29
Completion:: 2027-01-15

Conditions

Squamous Cell Carcinoma of Head and Neck

Interventions

OTHER

No Results Yet

NCT06069141 | RECRUITING | NA

688 participants

Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without Doxycycline

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-01-01
Completion:: 2027-12-31

Conditions

Early Syphilis, Latent, Serological Relapse After Treatment

Interventions

DRUG

No Results Yet

NCT06066528 | COMPLETED | PHASE3

755 participants

A Study to Test Whether Survodutide (BI 456906) Helps People Living With Overweight or Obesity Who Also Have Diabetes to Lose Weight

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-11-27
Completion:: 2025-12-12

Conditions

Obesity
Diabetes Mellitus, Type 2

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT06061614 | ACTIVE_NOT_RECRUITING | EARLY_PHASE1

15 participants

Safety and Efficacy Study of NGGT002 in PKU Adult Subjects

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-03-30
Completion:: 2028-12-30

Conditions

Phenylketonurias

Interventions

GENETIC

No Results Yet

NCT06060743 | COMPLETED | NA

88 participants

Examining the Effect of Mobile Application on Insulin Use Perception and Self-Management

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-01-01
Completion:: 2024-05-01

Conditions

Type 2 Diabetes Treated With Insulin

Interventions

OTHER

No Results Yet

NCT06056895 | ACTIVE_NOT_RECRUITING | PHASE2

12 participants

Triple Immune Checkpoint Inhibition for Advanced or Metastatic PD-(L)1 Refractory Merkel Cell Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-11-08
Completion:: 2027-01-31

Conditions

Unresectable Clinical Stage III Merkel Cell Carcinoma AJCC v8
Clinical Stage IV Merkel Cell Carcinoma AJCC v8
Merkel Cell Carcinoma

Interventions

PROCEDURE
BIOLOGICAL
DRUG

No Results Yet

NCT06056297 | RECRUITING | PHASE3

176 participants

A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-06-06
Completion:: 2027-09-30

Conditions

Neutropenia

Interventions

DRUG

No Results Yet

NCT06055920 | ACTIVE_NOT_RECRUITING | NA

1200 participants

The PEERLESS II Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-11-17
Completion:: 2026-08-31

Conditions

Pulmonary Embolism

Interventions

DEVICE
DRUG

No Results Yet

NCT06049212 | ACTIVE_NOT_RECRUITING | PHASE1

30 participants

Sacituzumab Tirumotecan (MK-2870) as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors (MK-2870-008)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-10-26
Completion:: 2026-12-31

Conditions

Non-small Cell Lung Cancer
Solid Tumors
Programmed Cell Death-1 (PD1, PD-1)
Programmed Cell Death 1 Ligand 1(PDL1, PD-L1)
Programmed Cell Death 1 Ligand 2 (PDL2, PD-L2)

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT06041581 | ENROLLING_BY_INVITATION | NA

200 participants

SHADES Mechanistic Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-04-25
Completion:: 2027-07-31

Conditions

Insomnia
Insomnia Chronic
Insomnia, Primary
Sleep Disturbance
Sleep Disorder
Cardiovascular Diseases
Heart Diseases
Coronary Artery Disease
Stroke
Autonomic Dysfunction
Systemic Inflammatory Response
Metabolic Disease

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT06030128 | COMPLETED | NA

150 participants

Core Stabilization Exercise Therapy in Chronic Lower Back Back Management in Community Dwelling Older Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-09-15
Completion:: 2025-05-01

Conditions

Chronic Low-back Pain
Older Adults
Core Stabilization Exercise Therapy

Interventions

BEHAVIORAL

No Results Yet

NCT05995821 | RECRUITING

1250 participants

Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2016-08-25
Completion:: 2028-08-25

Conditions

Head and Neck Cancer
Lung Cancer
Gastrointestinal Cancer

Interventions

OTHER

No Results Yet

NCT05990465 | RECRUITING | PHASE1

12 participants

LV20.19 CAR T-Cells in Combination With Pirtobrutinib for Relapsed, Refractory B-cell Malignancies

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2025-02-06
Completion:: 2028-07-31

Conditions

Non Hodgkin Lymphoma
Diffuse Large B Cell Lymphoma
Follicular Lymphoma
Marginal Zone Lymphoma
Mantle Cell Lymphoma
Burkitt Lymphoma

Interventions

DRUG

No Results Yet

NCT05988385 | RECRUITING | NA

200 participants

The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-08-29
Completion:: 2027-06-30

Conditions

Obstructive Sleep Apnea
Cognitive Decline

Interventions

DEVICE

No Results Yet

NCT05984238 | COMPLETED | NA

33 participants

A Trial to Evaluate Safety, Feasibility and Efficacy of Endoscopic Duodenal PEF Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-08-03
Completion:: 2025-03-21

Conditions

Diabetes Mellitus, Type 2

Interventions

DEVICE
DRUG
OTHER

No Results Yet

NCT05976763 | RECRUITING | PHASE3

421 participants

Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-10-20
Completion:: 2038-08-31

Conditions

Mantle Cell Lymphoma

Interventions

PROCEDURE
OTHER
DRUG
BIOLOGICAL

No Results Yet

NCT05958342 | RECRUITING | PHASE2

1050 participants

CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-06-30
Completion:: 2027-03-31

Conditions

Trauma
Hemorrhage

Interventions

DRUG

No Results Yet

NCT05952856 | COMPLETED | PHASE3

2912 participants

A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef Lipids

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-08-10
Completion:: 2025-07-28

Conditions

Hypercholesterolemia
Familial Hypercholesterolemia

Interventions

DRUG

Results Available

NCT05952024 | RECRUITING | PHASE2

80 participants

Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-07-16
Completion:: 2029-04-22

Conditions

Diffuse Large B-Cell Lymphoma

Interventions

DRUG
BIOLOGICAL

No Results Yet

NCT05944224 | RECRUITING | PHASE1/PHASE2

63 participants

A Study to Efficacy and Safety of SPH4336 Monotherapy or in Combination With Cadonilimab in Patients With Advanced Solid Tumors.

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-10-17
Completion:: 2026-12-31

Conditions

Advanced Solid Tumors

Interventions

DRUG

No Results Yet