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French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis

NCT06147843 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1000

Last updated 2024-11-25

No results posted yet for this study

Summary

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. Studies have shown the importance of weight loss at the time of diagnosis and during the progression of the disease. However, the pathophysiological mechanisms behind weight loss remain unknown. Identifying these mechanisms could make it possible to propose an effective therapeutic strategy against weight loss for ALS patients, which could improve their survival and quality of life. In this context, the investigators are proposing an innovative multidisciplinary project aimed at structuring a large Franco-German cohort to identify the markers associated with weight loss in ALS.

Participants will undergo high quality standard care for ALS patients. In addition, participants will be asked to respond different questionnaires and blood samples will be taken for analysis to identify biological markers.

Conditions

Interventions

OTHER

Blood sample

Blood sample will be taken to identify Genomic, metabolomic, metabolic, neurofilaments, and inflammation markers associated to weight loss

Sponsors & Collaborators

  • National Research Agency, France

    collaborator OTHER

  • Centre de Recherche en biomédecine de Strasbourg INSERM UMR-S1118

    collaborator UNKNOWN

  • Institut du Cerveau et de la Moelle épinière

    collaborator UNKNOWN

  • Institut National de la Santé et de la Recherche Médical - délégation Grand Ouest INSERM U1253

    collaborator UNKNOWN

  • Klinik für Neurologie, Universitäts- und Rehabilitationskliniken Ulm (RKU)

    collaborator UNKNOWN

  • Centre de Données Cliniques et de Recherche CDCR

    collaborator UNKNOWN

  • UMR Inserm U1253-IBRain-Neurogénétique et Physiopathologie Neuronale

    collaborator UNKNOWN

  • France Cohorte

    collaborator UNKNOWN

  • University Hospital, Limoges

    lead OTHER

Principal Investigators

  • Philippe COURATIER, Professor · University Hospital, Limoges

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-09-17
Primary Completion
2027-09-30
Completion
2029-09-30

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06147843 on ClinicalTrials.gov