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CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial

NCT05958342 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 1050

Last updated 2026-04-14

No results posted yet for this study

Summary

The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) Trial is a proposed 4 year, double-blind, mutli-center, prehospital and early in hospital phase randomized trial designed to determine the efficacy and safety of prehospital calcium and early in hospital vasopressin in patients at risk of hemorrhagic shock.

Conditions

Interventions

DRUG

Calcium Gluconate

1 gram calcium gluconate provided via intravenous or intraosseous access over approximately 2-5 minutes

DRUG

Vasopressin

4 unit vasopressin bolus followed by vasopressin infusion at 0.04 U/min for eight hours

DRUG

saline placebo

saline placebo volume matched to prehospital or in hospital phase

Sponsors & Collaborators

  • United States Department of Defense

    collaborator FED

  • Jason Sperry

    lead OTHER

Principal Investigators

  • Jason Sperry, MD · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-06-30
Primary Completion
2027-03-31
Completion
2028-03-31
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05958342 on ClinicalTrials.gov