Clinical Trials

NCT05850520 | COMPLETED | PHASE3
892 participants
NCT05786924 | RECRUITING | PHASE1/PHASE2
554 participants

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-17
Start Date:
2023-04-18
Completion:
2028-06-30
Conditions
  • Non-small Cell Lung Cancer
  • Histiocytic Neoplasm
  • Histiocytosis
  • BRAF Gene Mutation
  • BRAF V600E
  • BRAF V600 Mutation
  • BRAF Mutation-Related Tumors
  • BRAF
  • Metastatic Lung Non-Small Cell Carcinoma
  • Metastatic Lung Cancer
  • Recurrent Lung Cancer
  • Recurrent Lung Non-Small Cell Carcinoma
  • NSCLC
  • Solid Tumor
  • Solid Carcinoma
  • KRAS G12D
  • KRAS G12V
  • KRAS Mutation-Related Tumors
  • NRAS Gene Mutation
  • Thyroid Cancer
  • Thyroid Carcinoma
  • Colorectal Cancer
  • Colorectal Carcinoma
  • Recurrent Histiocytic and Dendritic Cell Neoplasm
  • Brain Metastases
  • Recurrent NSCLC
  • KRAS G13C
  • Acquired Resistance to KRAS G12C Inhibitor
  • KRAS G12A
  • KRAS G12F
  • KRAS G12R
  • KRAS G13D
Interventions
  • DRUG
No Results Yet
NCT05475925 | RECRUITING | PHASE1/PHASE2
200 participants

A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-17
Start Date:
2022-07-13
Completion:
2026-12-31
Conditions
  • LGLL - Large Granular Lymphocytic Leukemia
  • Primary Cutaneous Gamma-Delta T-Cell Lymphoma
  • Primary Cutaneous CD8+ Aggressive Epidermotropic T-Cell Lymphoma
  • Hepatosplenic T-cell Lymphoma
  • Subcutaneous Panniculitis-Like T-Cell Lymphoma
  • Aggressive NK Cell Leukemia
  • Systemic EBV1 T-cell Lymphoma, if CD8 Positive
  • Hydroa Vacciniforme-Like Lymphoproliferative Disorder
  • Extranodal NK/T Cell Lymphoma, Nasal Type
  • Enteropathy-Associated T-Cell Lymphoma
  • Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma
  • Cytotoxic PTCL-NOS (CD8+ or CD56+ and Cytotoxic Marker)
  • Cutaneous PTCL-NOS (CD8+ or CD56+ and Cytotoxic Marker)
Interventions
  • DRUG
No Results Yet
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