A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

Summary

The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

Conditions

• Spontaneous Coronary Artery Dissection
• Healthy

Interventions

OTHER

Arterial Tonometry

We will measure arterial stiffness using arterial tonometry.

DIAGNOSTIC_TEST

Echocardiogram

We will collect limited ultrasound images of the heart.

DIAGNOSTIC_TEST

Carotid Ultrasounds

We will perform ultrasound imaging of the carotid artery.

DIAGNOSTIC_TEST

Elastography

We will measure the elastic properties of the arteries using elastography.

OTHER

Ankle-Brachial Index

We will measure the ankle-brachial index to assess peripheral artery blood flow.

OTHER

Microneurography with sympathoexcitatory maneuvers

We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• Mayo Clinic

  lead OTHER

Principal Investigators

• Marysia Tweet, MD, MS · Mayo Clinic

Study Design

Allocation

NON_RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-06-01

Primary Completion

2027-08-31

Completion

2027-08-31

Countries

• United States

Study Locations