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Influence of Early-feeding on Digestive Function of Patients After Esophageal Recontraction Surgery

NCT05892263 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2023-06-07

No results posted yet for this study

Summary

After esophagectomy and reconstruction, intestinal ischemia or intestinal paralysis, lack of intestinal stimulation and oral nutrition can aggravate atrophy and impair the permeability of intestinal mucosa, which not only makes it easy for intestinal bacteria and endotoxin to migrate and enter the blood, At present, early intestinal feeding has been proved to protect the integrity of the intestinal mucosa and improve the postoperative systemic inflammatory response and infection rate of patients, especially pneumonia. Relying on parenteral nutrition, coupled with postoperative exhaust gas or defecation with drugs, can be force-fed. In addition to the side effects of gastrointestinal discomfort (nausea, diarrhea, abdominal pain), parenteral nutrition is likely to cause blood sugar instability and liver index. Abnormal and even increased infection rate, gastrointestinal force feeding was delayed for 36-48 hours before starting.

At present, there is no research on the effect of early force-feeding on gastrointestinal motility. Therefore, this study aims to explore whether early gastrointestinal force-feeding can not only reduce the infection rate and systemic inflammation, but also promote gastrointestinal motility. Without using drugs, Reduce drug side effects and abdominal discomfort, advance the time of gastrointestinal force-feeding, reduce complications of postoperative lung and wound anastomosis leakage, complete postoperative care for esophageal cancer, and reduce postoperative mortality.

At present, there is no research on the effect of early force-feeding on gastrointestinal motility. Therefore, this study aims to explore whether early gastrointestinal force-feeding can not only reduce the infection rate and systemic inflammation, but also promote gastrointestinal motility. Without using drugs, Reduce drug side effects and abdominal discomfort, advance the time of gastrointestinal force-feeding, reduce complications of postoperative lung and wound anastomosis leakage, complete postoperative care for esophageal cancer, and reduce postoperative mortality.

Conditions

  • Early-feeding

Interventions

OTHER

early feeding

Enteral force feeding with 5% dextrose injection within 24 hours after operation

Sponsors & Collaborators

  • National Taiwan University Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-11-01
Primary Completion
2025-07-08
Completion
2025-07-08

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05892263 on ClinicalTrials.gov