Clinical Trials

NCT04671667 | RECRUITING | PHASE2

188 participants

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2021-04-27
Completion:: 2029-06-30

Conditions

Recurrent Head and Neck Squamous Cell Carcinoma
Recurrent Hypopharyngeal Squamous Cell Carcinoma
Recurrent Laryngeal Squamous Cell Carcinoma
Recurrent Oral Cavity Squamous Cell Carcinoma
Recurrent Oropharyngeal Squamous Cell Carcinoma

Interventions

DRUG
PROCEDURE
RADIATION
BIOLOGICAL

No Results Yet

NCT04667455 | COMPLETED | NA

313 participants

Improving Care for Children With Congenital Heart Disease.

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-02-17
Completion:: 2026-05-04

Conditions

Heart Disease Congenital
Ventricular Septal Defect
Atrial Septal Defect
Patent Ductus Arteriosus
Partial Anomalous Pulmonary Venous Connection
Aortopulmonary Window
Cardiovascular Diseases

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04662580 | ACTIVE_NOT_RECRUITING | PHASE1

183 participants

ARX517/JNJ-95298177 as Monotherapy or Combination Therapy in Subjects With Metastatic Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2021-05-03
Completion:: 2026-12-31

Conditions

Metastatic Prostate Cancer

Interventions

DRUG

No Results Yet

NCT04658862 | ACTIVE_NOT_RECRUITING | PHASE3

518 participants

A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-12-07
Completion:: 2026-12-30

Conditions

Urinary Bladder Neoplasms

Interventions

DRUG
RADIATION
BIOLOGICAL

No Results Yet

NCT04644770 | ACTIVE_NOT_RECRUITING | PHASE1

144 participants

A Study of JNJ-69086420, an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-11-12
Completion:: 2026-12-08

Conditions

Prostatic Neoplasms
Adenocarcinoma

Interventions

DRUG
RADIATION

No Results Yet

NCT04642352 | RECRUITING

50 participants

Office-Based Superior Laryngeal Nerve Block for Treatment of Neurogenic Cough

Study Type:: OBSERVATIONAL
Last Updated:: 2026-05-08
Start Date:: 2022-01-03
Completion:: 2026-10-31

Conditions

Cough

Interventions

DRUG

No Results Yet

NCT04641416 | RECRUITING

60 participants

Noninvasive Cardiovascular Diagnosis of Patients With Fully Magnetically Levitated Blood Pumps

Study Type:: OBSERVATIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-07-09
Completion:: 2026-12-15

Conditions

End-stage Heart Failure
Cardiomyopathies
Mechanical Circulatory Support

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04640623 | ACTIVE_NOT_RECRUITING | PHASE2

220 participants

A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-12-18
Completion:: 2025-07-03

Conditions

Urinary Bladder Neoplasms

Interventions

DRUG
BIOLOGICAL

No Results Yet

NCT04637282 | NOT_YET_RECRUITING | PHASE3

39 participants

Safety, Tolerability, and Efficacy of PLX-200 in Patients With CLN3

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2026-11-01
Completion:: 2026-12-31

Conditions

Juvenile Neuronal Ceroid Lipofuscinosis

Interventions

DRUG

No Results Yet

NCT04634552 | RECRUITING | PHASE2

510 participants

A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2021-02-01
Completion:: 2027-06-30

Conditions

Hematological Malignancies

Interventions

DRUG

No Results Yet

NCT04632602 | COMPLETED | NA

20 participants

Awake Prone Position to Reduce Ventilation Inhomogeneity in COVID-19 Acute Respiratory Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-04-14
Completion:: 2020-11-29

Conditions

Respiratory Failure

Interventions

OTHER

No Results Yet

NCT04627246 | ACTIVE_NOT_RECRUITING | PHASE1

14 participants

Personalized Vaccine With SOC Chemo Followed by Nivo in Pancreatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-09-11
Completion:: 2028-09-30

Conditions

Pancreatic Adenocarcinoma

Interventions

BIOLOGICAL

No Results Yet

NCT04620915 | COMPLETED | NA

300 participants

Construal Level as a Novel Pathway for Affect Regulation and Cancer Control

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2021-10-11
Completion:: 2025-08-30

Conditions

Smoking Cessation
Smoking Reduction
Cancer

Interventions

BEHAVIORAL

No Results Yet

NCT04618471 | ACTIVE_NOT_RECRUITING | NA

177 participants

Paresthesia-Free Fast-Acting Subperception (FAST) Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2021-02-10
Completion:: 2022-12-14

Conditions

Chronic Pain

Interventions

DEVICE

Results Available

NCT04606381 | ACTIVE_NOT_RECRUITING | PHASE1

158 participants

A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-11-10
Completion:: 2024-07-11

Conditions

Neoplasms

Interventions

DRUG

No Results Yet

NCT04602572 | NOT_YET_RECRUITING

400 participants

Obesity and Oral Diseases in Adult Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2026-05-08
Start Date:: 2026-11-01
Completion:: 2027-12-30

Conditions

Obesity
Oral Diseases
Periodontitis
Dental Caries
Dental Erosion

Interventions

BEHAVIORAL
PROCEDURE

No Results Yet

NCT04599088 | COMPLETED | NA

207 participants

Investigation of Brain Mechanisms Involved in the Urinary Continence Mechanism Associated With Aging

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-12-14
Completion:: 2025-07-31

Conditions

Urgency Urinary Incontinence

Interventions

OTHER

No Results Yet

NCT04589845 | ACTIVE_NOT_RECRUITING | PHASE2

920 participants

Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2021-01-18
Completion:: 2032-09-25

Conditions

Solid Tumors

Interventions

DRUG

No Results Yet

NCT04579276 | COMPLETED | NA

180 participants

Different Approaches to Thoracic Paravertebral Block

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-09-08
Completion:: 2021-12-08

Conditions

Thoracotomy

Interventions

PROCEDURE

No Results Yet

NCT04577833 | ACTIVE_NOT_RECRUITING | PHASE1

136 participants

A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-11-13
Completion:: 2021-10-15

Conditions

Prostatic Neoplasms

Interventions

DRUG

No Results Yet

NCT04565613 | COMPLETED | NA

34 participants

Protein Supplementation vs Standard Feeds in Underweight Critically Ill Children: A Dual-Centre Pilot RCT

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2021-01-25
Completion:: 2024-09-01

Conditions

Critically Ill

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT04557059 | ACTIVE_NOT_RECRUITING | PHASE3

692 participants

A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-11-12
Completion:: 2029-08-27

Conditions

Prostatic Neoplasms

Interventions

RADIATION
DRUG

No Results Yet

NCT04538664 | ACTIVE_NOT_RECRUITING | PHASE3

308 participants

A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-10-13
Completion:: 2023-05-03

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

DRUG

Results Available

NCT04516811 | TERMINATED | PHASE3

102 participants

Therapeutic Use of Convalescent Plasma in the Treatment of Patients With Moderate to Severe COVID-19

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-09-21
Completion:: 2021-12-30

Conditions

COVID-19
SARS-CoV-2 Infection
Severe Acute Respiratory Syndrome Coronavirus 2

Interventions

BIOLOGICAL

No Results Yet

NCT04502407 | ACTIVE_NOT_RECRUITING | PHASE2

40 participants

Trial of De-Intensified Post-operative Chemoradiation Following Robotic Surgery for HPV-positive Oropharyngeal Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2021-02-16
Completion:: 2026-12-15

Conditions

HPV Positive Oropharyngeal Squamous Cell Carcinoma

Interventions

RADIATION
DRUG

No Results Yet

NCT04487080 | ACTIVE_NOT_RECRUITING | PHASE3

1074 participants

A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-09-30
Completion:: 2023-08-11

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

DRUG

Results Available

NCT04474548 | TERMINATED | NA

103 participants

Postplacental LNG-IUD Ultrasound Use Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-10-05
Completion:: 2023-10-01

Conditions

IUD Insertion Complication

Interventions

OTHER

No Results Yet

NCT04465591 | RECRUITING

1500 participants

TROPOnin FRAGMentation in Myocardial Injury Study

Study Type:: OBSERVATIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-04-02
Completion:: 2028-12-30

Conditions

Acute Myocardial Infarction Type 1
Myocardial Injury

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04463979 | ACTIVE_NOT_RECRUITING

66 participants

Perioperative Evaluation of Cerebellar Tumors

Study Type:: OBSERVATIONAL
Last Updated:: 2026-05-08
Start Date:: 2021-02-28
Completion:: 2025-05-16

Conditions

Cerebellar Tumors
Brain Tumor

Interventions

OTHER

No Results Yet

NCT04461821 | RECRUITING

3600 participants

Exhaled Breath Analysis by Secondary Electrospray Ionization - Mass Spectrometry in Children and Adolescents

Study Type:: OBSERVATIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-09-11
Completion:: 2030-07-31

Conditions

Respiratory Diseases
Neurological Disorders
Type 1 Diabetes

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04460586 | COMPLETED | PHASE4

9 participants

Pharmacokinetics of Omadacycline in Cystic Fibrosis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2021-07-01
Completion:: 2023-12-01

Conditions

Cystic Fibrosis

Interventions

DRUG

Results Available

NCT04458207 | ACTIVE_NOT_RECRUITING | NA

80 participants

Cognitive Changes and Neural Correlates After Rehabilitation of Masticatory Function in Elderly -an Intervention Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2018-11-02
Completion:: 2026-12-30

Conditions

Chewing Problem
Cognitive Decline
Magnetic Resonance Imaging
Degenerative; Dementia
Mastication Disorder
Neurocognitive Dysfunction

Interventions

PROCEDURE

No Results Yet

NCT04444492 | ACTIVE_NOT_RECRUITING | PHASE3

88 participants

Combination of Ranibizumab and Targeted Laser Photocoagulation

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-08-25
Completion:: 2027-11-30

Conditions

Central Retinal Vein Occlusion With Macular Edema

Interventions

DRUG
DEVICE

No Results Yet

NCT04439110 | ACTIVE_NOT_RECRUITING | PHASE2

38 participants

Testing Ado-Trastuzumab Emtansine as a Potential Targeted Treatment in Cancers With HER2 Genetic Changes (MATCH-Subprotocol Q)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2015-08-12
Completion:: 2019-03-09

Conditions

Advanced Lymphoma
Advanced Malignant Solid Neoplasm
Hematopoietic and Lymphoid Cell Neoplasm
Refractory Lymphoma
Refractory Malignant Solid Neoplasm
Refractory Multiple Myeloma

Interventions

BIOLOGICAL

Results Available

NCT04428944 | ACTIVE_NOT_RECRUITING | NA

617 participants

STrategies for Catheter Ablation of peRsistent Atrial Fibrlllation

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2021-06-01
Completion:: 2027-09-30

Conditions

Atrial Fibrillation

Interventions

PROCEDURE

No Results Yet

NCT04425265 | RECRUITING | NA

500 participants

Plasma Radiofrequency Ablation at Low Temperature Versus Electrocautery Block Resection at High Frequency for Localized Recurrent Nasopharyngeal Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-06-30
Completion:: 2026-12-31

Conditions

Surgery
Recurrent Nasopharyngeal Carcinoma

Interventions

PROCEDURE

No Results Yet

NCT04414540 | ACTIVE_NOT_RECRUITING | PHASE2

21 participants

Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2020-08-31
Completion:: 2026-02-02

Conditions

Head and Neck Squamous Cell Carcinoma

Interventions

DRUG

Results Available

NCT04372108 | RECRUITING

1056 participants

A Study to Assess the Long-Term Safety of Ustekinumab Versus Other Biologics in Patients With Crohn's Disease and Ulcerative Colitis

Study Type:: OBSERVATIONAL
Last Updated:: 2026-05-08
Start Date:: 2021-06-24
Completion:: 2029-08-31

Conditions

Crohn Disease
Colitis, Ulcerative

Interventions

DRUG

No Results Yet

NCT04360681 | COMPLETED | PHASE2

84 participants

Lofexidine Combined With Buprenorphine for Reducing Symptoms of PTSD and OU Relapse in Veterans

Study Type:: INTERVENTIONAL
Last Updated:: 2026-05-08
Start Date:: 2021-03-09
Completion:: 2025-12-15

Conditions

Post Traumatic Stress Disorder
Opioid-use Disorder

Interventions

DRUG

No Results Yet

NCT04354129 | ACTIVE_NOT_RECRUITING

36 participants

Observational Study of Subcutaneous Immunoglobulin (Cutaquig) in Patients With Primary and Secondary Immunodeficiency.

Study Type:: OBSERVATIONAL
Last Updated:: 2026-05-08
Start Date:: 2023-04-01
Completion:: 2026-07-31

Conditions

Primary Immune Deficiency Disorder
Secondary Immune Deficiency

Interventions

DRUG

No Results Yet