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TROPOnin FRAGMentation in Myocardial Injury Study

NCT04465591 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1500

Last updated 2026-05-08

No results posted yet for this study

Summary

Troponin T (TnT) is a part of the troponin protein complex that principally exists in cardiac and skeletal muscle cells and is widely used as diagnostic biomarker for myocardial injury and, thus, myocardial infarction (MI). Elevated TnT levels can, however, be observed in the presence of other clinical conditions such as heart failure, sepsis and kidney failure and the contemporary high-sensitivity TnT test may yield false positive results when performing diagnostics for suspected MI in these patients.

Recent data have demonstrated that in the presence of MI, TnT gradually undergoes fragmentation into smaller fragments. It has been suggested that in the presence of e.g. chronic kidney disease or physical exercise the released TnT is predominantly in the form of smaller fragments.

However, the clinical significance of TnT fragmentation is unknown and, thus, we sought to investigate the prevalence of fragmentation of TnT in different patient cohorts.

Conditions

  • Acute Myocardial Infarction Type 1
  • Myocardial Injury

Interventions

DIAGNOSTIC_TEST

troponin T fragmentation test

laboratory test from blood sample

Sponsors & Collaborators

  • University of Turku

    lead OTHER

Principal Investigators

  • Juhani K Airaksinen, MD, PhD · University of Turku

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-04-02
Primary Completion
2028-12-30
Completion
2028-12-31

Countries

  • Finland
  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04465591 on ClinicalTrials.gov