Clinical Trials Updated in 2025

NCT05257824 | COMPLETED | PHASE4

528 participants

Optimal Duration of Dual Antiplatelet Therapy After Stent-assisted Coiling

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2022-06-23
Completion:: 2025-12-02

Conditions

Aneurysm Cerebral
Endovascular Procedures

Interventions

DRUG

No Results Yet

NCT05249101 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

70 participants

A Study of Ivaltinostat Plus Capecitabine or Capecitabine in Metastatic Pancreatic Adenocarcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2022-08-15
Completion:: 2026-06-30

Conditions

Metastatic Pancreatic Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT05235425 | COMPLETED | NA

304 participants

The Lifestyle Education About Prediabetes (Leap) Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2022-03-20
Completion:: 2025-11-14

Conditions

PreDiabetes

Interventions

BEHAVIORAL

No Results Yet

NCT05208710 | RECRUITING | EARLY_PHASE1

45 participants

PANHPVAX, Study of a New HPV Vaccine in Healthy Volunteers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2022-11-07
Completion:: 2027-12-31

Conditions

HPV

Interventions

BIOLOGICAL

No Results Yet

NCT05201469 | RECRUITING | PHASE2

74 participants

VIBRANT: VIB4920 for Active Lupus Nephritis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2022-05-16
Completion:: 2026-08-31

Conditions

Lupus Nephritis

Interventions

DRUG

No Results Yet

NCT05153395 | SUSPENDED | EARLY_PHASE1

65 participants

Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-12-01
Completion:: 2027-06-30

Conditions

Healthy
Vasodilation
Insulin Resistance
Autonomic Dysfunction
Obesity

Interventions

OTHER
DRUG

No Results Yet

NCT05115630 | COMPLETED | PHASE2

24 participants

Off-the-shelf NK Cells + SCT for Myeloid Malignancies

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2022-04-08
Completion:: 2025-05-15

Conditions

Myeloid Malignancies
Acute Myeloid Leukemia
Myelodysplastic Syndrome
Chronic Myeloid Leukemia

Interventions

DRUG

Results Available

NCT05093933 | COMPLETED | PHASE3

6106 participants

A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-11-02
Completion:: 2024-11-20

Conditions

Chronic Heart Failure With Reduced Ejection Fraction

Interventions

DRUG

Results Available

NCT05088798 | RECRUITING | PHASE2

100 participants

Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2020-09-10
Completion:: 2030-01-01

Conditions

Hyperinsulinism

Interventions

DRUG

No Results Yet

NCT05071352 | COMPLETED | PHASE3

60 participants

Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-10-01
Completion:: 2023-03-01

Conditions

Analgesia
Critical Illness
Mechanical Ventilation
Sedation

Interventions

DRUG

No Results Yet

NCT05069259 | TERMINATED

18 participants

Generate Real World Data On Tofacitinib Induction Therapy and Changes In Clinical and Patient Reported Outcomes.

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-19
Start Date:: 2022-03-28
Completion:: 2024-04-30

Conditions

Ulcerative Colitis

Interventions

OTHER

Results Available

NCT05047536 | TERMINATED | PHASE1

61 participants

KZR-261 in Subjects With Advanced Solid Malignancies

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-09-30
Completion:: 2025-01-17

Conditions

Advanced/Metastatic Solid Tumor

Interventions

DRUG

Results Available

NCT05036616 | COMPLETED | NA

80 participants

Separation Versus Integrated Approach in Combining ECMO With CRRT

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-04-01
Completion:: 2025-03-10

Conditions

AKI

Interventions

DEVICE

No Results Yet

NCT04996082 | COMPLETED

26 participants

Skin Fibrosis Analysis by Raman Spectroscopy in Systemic Sclerosis

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-04-08
Completion:: 2023-07-21

Conditions

Validation of Raman Spectroscopy Usefulness in Systemic Sclerosis

No Results Yet

NCT04983654 | COMPLETED | NA

70 participants

Functional and Mechanistic Characterization of Limb Ulcers in Patients With Sickle Cell Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2022-02-09
Completion:: 2023-10-03

Conditions

Ulcer
Anemia
Sickle Cell Disease

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04962477 | COMPLETED

48 participants

Understanding Host-pathogen Interaction in the Respiratory Mucosa During Pregnancy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-19
Start Date:: 2022-03-02
Completion:: 2023-09-27

Conditions

Pregnancy Related
Innate Inflammatory Response

Interventions

OTHER

No Results Yet

NCT04913038 | COMPLETED

50 participants

Validation of the ANI in Perpubescent Patients in Pediatric Intensive Care Unit.

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-06-29
Completion:: 2023-11-22

Conditions

Pain
Pediatric ALL

No Results Yet

NCT04841746 | COMPLETED | NA

22 participants

Efficacy of FES Cycling After a Severe Form of COVID-19

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-06-02
Completion:: 2024-10-02

Conditions

Covid19
Ventilators, Mechanical
Respiratory Distress Syndrome

Interventions

BEHAVIORAL

No Results Yet

NCT04831138 | TERMINATED | NA

6 participants

Non-Contrast Perfusion Using Arterial Spin Labeled MR Imaging for Assessment of Therapy Response in Metastatic Renal Cell Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-03-24
Completion:: 2023-04-04

Conditions

Renal Cell Carcinoma

Interventions

OTHER

Results Available

NCT04817449 | COMPLETED

160 participants

Spectroscopy in Ovarian Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-06-28
Completion:: 2023-10-01

Conditions

Ovarian Cancer
Ovarian Neoplasms
Ovary Cyst
Ovary Disease

No Results Yet

NCT04783701 | RECRUITING

360 participants

Coronary CT Angio Evaluating Graft Patency in ACS Patients Treated With DAPT or Single ASA After CABG (CoCAP)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-05-17
Completion:: 2026-02-01

Conditions

Acute Coronary Syndrome
Coronary Bypass Stenosis

No Results Yet

NCT04783506 | COMPLETED

225 participants

Characterizing Inflammatory Profiles and Suicidal Behavior in Adolescents

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-04-28
Completion:: 2025-06-15

Conditions

Suicide and Depression

Interventions

OTHER

No Results Yet

NCT04783233 | WITHDRAWN

0 participants

Chitogel CSK-4 Gel as Packing in Tympanoplasty Surgery

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-01-14
Completion:: 2021-11-03

Conditions

Tympanoplasty Surgery

Interventions

BIOLOGICAL

No Results Yet

NCT04782180 | COMPLETED | PHASE4

90 participants

PrEP at a Syringe Services Program

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2022-02-01
Completion:: 2024-11-11

Conditions

Hiv
Substance Use Disorders

Interventions

DRUG
BEHAVIORAL

Results Available

NCT04768309 | COMPLETED | NA

20 participants

Impact of Intestinal Microbiota on Uremic Toxins Productions

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-06-04
Completion:: 2021-07-13

Conditions

CKD
Uremia

Interventions

OTHER

No Results Yet

NCT04741269 | COMPLETED

98 participants

Asymmetric Lack of Knee Flexion as a Symptom of DLM in Children

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-19
Start Date:: 2020-09-01
Completion:: 2020-11-01

Conditions

Highlights a New Clinical Sign Which Point Out a Meniscus Posterior Luxation Because of a MCA-type DLM

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04691960 | ACTIVE_NOT_RECRUITING | PHASE2

18 participants

A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2016-08-31
Completion:: 2026-06-30

Conditions

Glioblastoma

Interventions

OTHER
DRUG

No Results Yet

NCT04691297 | ACTIVE_NOT_RECRUITING | NA

153 participants

Digitally Enhanced Smoking Cessation for High Risk Smokers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-02-01
Completion:: 2023-02-01

Conditions

Smoking
Smoking Cessation
Lung Cancer Screening
Smoking, Tobacco
Smoking Behaviors

Interventions

OTHER

No Results Yet

NCT04625478 | COMPLETED

50 participants

Clinical Relevance of Intracellular Staphylococci in BOne and Joint Infections

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-19
Start Date:: 2020-12-01
Completion:: 2021-09-20

Conditions

Bone and Joint Infection
Staphylococcus

Interventions

OTHER

No Results Yet

NCT04585503 | COMPLETED | NA

20 participants

Feasibility Study of Cortical Recording Depolarizations in Brain-injured Patients, and Their Use as Biomarkers of New Lesions.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-01-01
Completion:: 2023-04-07

Conditions

Brain Lesion
Head Trauma
Subarachnoid Hemorrhage

Interventions

DEVICE

No Results Yet

NCT04579848 | ACTIVE_NOT_RECRUITING | PHASE4

163 participants

Methotrexate in Erosive Inflammatory Hand Osteoarthritis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-08-12
Completion:: 2026-12-31

Conditions

Hand Osteoarthritis
Erosive Osteoarthritis

Interventions

DRUG

No Results Yet

NCT04550104 | RECRUITING | PHASE1

200 participants

A Platform Study of Novel Agents in Combination With Radiotherapy in NSCLC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-03-17
Completion:: 2026-03-31

Conditions

Non Small Cell Lung Cancer

Interventions

RADIATION
DRUG

No Results Yet

NCT04517279 | COMPLETED | NA

113 participants

Peer Approaches to Substances in Early Psychosis Programs: A Pilot Study of a Peer-Led Intervention

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2023-08-22
Completion:: 2025-07-25

Conditions

Psychotic Disorders
Substance Use

Interventions

BEHAVIORAL

No Results Yet

NCT04495296 | RECRUITING | PHASE1/PHASE2

320 participants

A Trial to Evaluate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TST001 in Advanced or Metastatic Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2020-08-13
Completion:: 2026-06-25

Conditions

Advanced Cancer

Interventions

DRUG

No Results Yet

NCT04464707 | COMPLETED | PHASE3

292 participants

A Study to Test if Fremanezumab is Effective in Preventing Chronic Migraine in Participants 6 to 17 Years of Age

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2020-09-24
Completion:: 2024-11-29

Conditions

Migraine

Interventions

DRUG

Results Available

NCT04447118 | COMPLETED | PHASE3

151 participants

Phase 3 Study of Pyrotinib Versus Docetaxel in Patients With Advanced Non-squamous NSCLC Harboring a HER2 Exon 20 Mutation Who Failed Platinum Based Chemotherapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2020-09-11
Completion:: 2023-06-02

Conditions

Non-squamous NSCLC
HER2 Exon 20 Mutation

Interventions

DRUG

No Results Yet

NCT04439552 | RECRUITING

60 participants

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-19
Start Date:: 2021-10-04
Completion:: 2027-08-31

Conditions

Pain, Postoperative
Pain, Chronic
Pain, Acute
Surgical Injury
Surgical Wound
Cornea Injury
Cornea
Keratoconus

No Results Yet

NCT04435054 | COMPLETED | NA

1000 participants

Screening for NAFLD-related Advanced Fibrosis in High Risk Population in Diabetology.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2020-10-28
Completion:: 2023-10-28

Conditions

Non-Alcoholic Fatty Liver Disease

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04411602 | WITHDRAWN | PHASE1

0 participants

Intermediate IND Severe Illness COVID-19 CP

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2020-04-07
Completion:: 2021-04-07

Conditions

Severe Acute Respiratory Syndrome
COVID

Interventions

DRUG

No Results Yet

NCT04379921 | COMPLETED | NA

255 participants

Improving Spine Surgical Care With Real-Time Objective Patient Tracking Using the Apple Watch

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-19
Start Date:: 2020-09-01
Completion:: 2024-11-30

Conditions

Spine Disease
Spine Degeneration
Spinal Stenosis
Surgery
Spine Fusion

Interventions

DEVICE

Results Available