Clinical Trials Updated in 2025

NCT05118490 | ACTIVE_NOT_RECRUITING | PHASE4

1000 participants

Comparing Treatment Completion Of Daily Rifapentine & Isoniazid For One Month (1HP) To Weekly High Dose Rifapentine & Isoniazid For 3 Months (3HP) In Persons Living With HIV and in Household Contacts of Recently Diagnosed Tuberculosis Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2023-07-19
Completion:: 2025-07-11

Conditions

HIV Seropositivity
Tuberculosis
Household Contact

Interventions

DRUG

No Results Yet

NCT05018728 | TERMINATED | PHASE2

22 participants

The Effect of Voxelotor on Cerebral Hemodynamic Response in Children With Sickle Cell Anemia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-03-28
Completion:: 2024-10-22

Conditions

Sickle Cell Anemia in Children

Interventions

DRUG

No Results Yet

NCT05008809 | RECRUITING | PHASE3

507 participants

Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-12-06
Completion:: 2027-11-30

Conditions

Colorectal Cancer

Interventions

DRUG

No Results Yet

NCT04998370 | COMPLETED

366 participants

Cerebrospinal Fluid Hemoglobin to Monitor for Aneurysmal Subarachnoid Hemorrhage Related Secondary Brain Injury

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-08-18
Completion:: 2024-09-30

Conditions

Subarachnoid Hemorrhage, Aneurysmal
Vasospasm
Delayed Cerebral Ischemia
Delayed Ischemic Neurological Deficit

No Results Yet

NCT04976621 | COMPLETED | NA

46 participants

ACTIVE: Activity Therapy to Increase Veteran Engagement

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-02-15
Completion:: 2024-04-16

Conditions

Traumatic Brain Injury

Interventions

BEHAVIORAL
OTHER

Results Available

NCT04961619 | COMPLETED

39 participants

Adjuvant Dabrafenib and Trametinib Treatment in Patients With Completely Resected High-risk Stage III Melanoma.

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-12-01
Completion:: 2024-12-05

Conditions

Melanoma

Interventions

DRUG

No Results Yet

NCT04940078 | COMPLETED | PHASE1

40 participants

A Research Study to Compare Blood Levels of Cagrilintide and Semaglutide After Combined Versus Separate Injections in People With Overweight or Obesity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-07-07
Completion:: 2022-01-19

Conditions

Obesity & Overweight

Interventions

DRUG

No Results Yet

NCT04939519 | COMPLETED | NA

65300 participants

SCALE-UP Utah: Community-Academic Partnership to Address COVID-19 Vaccination Rates Among Utah Community Health Centers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-03-29
Completion:: 2022-06-17

Conditions

Covid19

Interventions

BEHAVIORAL

Results Available

NCT04918030 | COMPLETED | NA

1586 participants

STaged Interventional Strategies for Acute ST-seGment Elevation Myocardial Infarction Patient With Multi-vessel Disease（STAGED）

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-02-11
Completion:: 2025-02-01

Conditions

STEMI
Multi Vessel Coronary Artery Disease
Percutaneous Coronary Intervention
AMI Patients With Multivessel Disease, Staged PCI

Interventions

PROCEDURE

No Results Yet

NCT04913753 | COMPLETED | NA

2200 participants

Relevance of the Urine Bacterial Culture Performed Before Double J Ablation for Post-operative Urinary Tract Infection Prevention

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-06-10
Completion:: 2025-12-03

Conditions

Urinary Infection

Interventions

PROCEDURE

No Results Yet

NCT04862949 | COMPLETED

131 participants

Organ-specific Responses to Atezolizumab Plus Bevacizumab in Advanced HCC

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-05-01
Completion:: 2022-12-31

Conditions

Advanced Hepatocellular Carcinoma

Interventions

DRUG

Results Available

NCT04846881 | COMPLETED | PHASE3

611 participants

Clinical Trial of Iclepertin Effect on Cognition and Functional Capacity in Schizophrenia (CONNEX-2)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-08-24
Completion:: 2024-10-18

Conditions

Schizophrenia

Interventions

DRUG

Results Available

NCT04771078 | AVAILABLE

Expanded Access Protocol (EAP) for Participants Receiving Idecabtagene Vicleucel That is Nonconforming for Commercial Release

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-12-12

Conditions

Multiple Myeloma

Interventions

BIOLOGICAL

No Results Yet

NCT04770519 | RECRUITING

400 participants

Genetic Studies of Strabismus, Nystagmus, and Associated Disorders

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-09-03
Completion:: 2030-12-31

Conditions

Strabismus
Nystagmus, Congenital

Interventions

GENETIC

No Results Yet

NCT04745754 | ACTIVE_NOT_RECRUITING | NA

2450 participants

The Engaging Primary Care in Cancer Survivorship (EPICS) Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-09-21
Completion:: 2026-02-28

Conditions

Breast Cancer
Colorectal Cancer

Interventions

OTHER

No Results Yet

NCT04722887 | COMPLETED | PHASE1/PHASE2

17 participants

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-08-13
Completion:: 2025-08-01

Conditions

Alpha1-Antitrypsin Deficiency

Interventions

BIOLOGICAL

No Results Yet

NCT04713722 | RECRUITING

160 participants

Early Life Stress and Depression: Molecular and Functional Imaging

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-02-01
Completion:: 2026-06-30

Conditions

Depression
Trauma, Psychological

No Results Yet

NCT04710316 | COMPLETED | NA

450 participants

Study of COVID-19 Outbreak in Hospital Departments of Bamako, Mali

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-02-15
Completion:: 2022-04-30

Conditions

Covid19

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04706507 | TERMINATED | PHASE3

205 participants

Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients With Acute Respiratory Failure and Sepsis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-06-29
Completion:: 2024-10-25

Conditions

Acute Respiratory Failure

Interventions

DRUG

Results Available

NCT04678960 | COMPLETED | NA

250 participants

Preventing Opioid Use Among Justice-involved Youth as They Transition to Adulthood Leveraging Safe Adults (LeSA)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-02-15
Completion:: 2025-09-30

Conditions

Opioid Use
Substance Use

Interventions

BEHAVIORAL

No Results Yet

NCT04610697 | RECRUITING | NA

30 participants

Cognitive Remediation in Forensic Mental Health Care

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2020-02-10
Completion:: 2026-02-10

Conditions

Psychotic Disorders
ADHD
TBI (Traumatic Brain Injury)
Aggression
Substance Use Disorders
Violence
Cognitive Dysfunction
Anxiety
Depression
Schizophrenia
Offenders
Antisocial

Interventions

BEHAVIORAL

No Results Yet

NCT04603183 | COMPLETED | PHASE2

162 participants

ABemaciclib, ET ± paclItaxel in aGgressive HR+/HER2- MBC trIaL

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-06-02
Completion:: 2024-06-30

Conditions

Breast Cancer Metastatic

Interventions

DRUG

No Results Yet

NCT04552600 | COMPLETED | PHASE1/PHASE2

100 participants

Study to Evaluate Clinical Efficacy and Safety of Nuvastatic™ - C5OSEW5050ESA in Diabetic Retinopathy.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-09-01
Completion:: 2022-08-10

Conditions

Diabetic Retinopathy

Interventions

DRUG
OTHER

No Results Yet

NCT04507126 | COMPLETED | PHASE2

20 participants

A Pilot Study of the Effects of BCG Immunization on CSF and Blood-based Biomarkers in Older Adults.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-03-01
Completion:: 2022-12-09

Conditions

Healthy

Interventions

BIOLOGICAL

Results Available

NCT04481451 | WITHDRAWN | PHASE4

0 participants

Quadratus Lumborum vs Erector Spinae Supplementary Blocks With Lumbar Plexus Blocks for Hip PAO

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2020-12-01
Completion:: 2025-12-01

Conditions

Pain, Postoperative
Regional Anesthesia
Hip Dysplasia

Interventions

PROCEDURE
DRUG

No Results Yet

NCT04325529 | ACTIVE_NOT_RECRUITING

148 participants

Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Study 1.2 (Stress Manipulation)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-01-19
Completion:: 2026-06-30

Conditions

Major Depression in Remission

Interventions

DEVICE

No Results Yet

NCT04278521 | ACTIVE_NOT_RECRUITING | NA

54 participants

Mechanism of Action of Transcranial Magnetic Stimulation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2011-11-30
Completion:: 2026-06-30

Conditions

Major Depressive Disorder
Depression

Interventions

DEVICE

No Results Yet

NCT04270409 | ACTIVE_NOT_RECRUITING | PHASE3

337 participants

Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2020-06-16
Completion:: 2030-10-14

Conditions

Plasma Cell Myeloma

Interventions

DRUG

No Results Yet

NCT04266041 | COMPLETED | NA

122 participants

High-density EEG in Neurological Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2018-02-09
Completion:: 2024-05-31

Conditions

Epilepsy
Tumor
Healthy

Interventions

DIAGNOSTIC_TEST

Results Available

NCT04230096 | COMPLETED | NA

108 participants

Effects Of Low Level Laser Therapy On Tooth Movement,Treatment Related Complications Of Gingivitis,Periodontitis And Pain In Fixed Orthodontic Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2023-12-01
Completion:: 2024-02-28

Conditions

Gingivitis
Pain
Periodontitis
Tooth Migration

Interventions

DEVICE

No Results Yet

NCT04175041 | ACTIVE_NOT_RECRUITING | NA

104 participants

A Dose-Response Study of the Cognitive and Physiological Effects of tDCS to the DLPFC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-07-09
Completion:: 2026-05-31

Conditions

Attention Deficit Hyperactivity Disorder

Interventions

DEVICE

No Results Yet

NCT04175028 | COMPLETED | NA

83 participants

Neuromodulation of Executive Function in the ADHD Brain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2014-09-30
Completion:: 2018-06-01

Conditions

Attention Deficit Hyperactivity Disorder

Interventions

DEVICE

No Results Yet

NCT04166526 | RECRUITING

8 participants

A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-10-25
Completion:: 2027-05-01

Conditions

Sickle Cell Disease

Interventions

DEVICE

No Results Yet

NCT04145518 | COMPLETED | PHASE4

183 participants

Mechanistic Characterization of Uterine Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-10-25
Completion:: 2025-07-23

Conditions

Dysmenorrhea (Disorder)
Dysmenorrhea Primary
Dysmenorrhea Secondary
Endometrial Diseases
Leiomyoma
Fibroid Uterus

Interventions

DRUG

No Results Yet

NCT04122079 | COMPLETED

1120 participants

Validation of the Spanish Version of the Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM) in Chile

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-01-09
Completion:: 2021-09-30

Conditions

Psychological Distress

No Results Yet

NCT04121091 | COMPLETED | PHASE2

13 participants

Pramipexole to Target "Anhedonic Depression"

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-10-04
Completion:: 2021-03-18

Conditions

Depression, Bipolar
Depression, Unipolar
Dysthymia
Anhedonia

Interventions

DRUG

Results Available

NCT04075890 | COMPLETED | NA

66 participants

Arbitration Between Habitual and Goal-directed Behavior in Obsessive-compulsive Disorder: Circuit Dynamics and Effects of Noninvasive Neurostimulation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-07-15
Completion:: 2024-01-31

Conditions

OCD
Decision-Making
tDCS
fMRI

Interventions

DEVICE

Results Available

NCT04027881 | COMPLETED | NA

15 participants

Improving Print Knowledge for Children With Hearing Loss

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2020-01-10
Completion:: 2021-05-20

Conditions

Hearing Loss

Interventions

BEHAVIORAL

No Results Yet

NCT04027257 | COMPLETED | NA

20 participants

Sit Together and Read (STAR): A Pilot Study of Children and Their Kinship Caregivers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-10-01
Completion:: 2021-05-31

Conditions

Reading

Interventions

BEHAVIORAL

No Results Yet

NCT03999424 | COMPLETED | PHASE1

5 participants

Autologous Human Schwann Cells in Peripheral Nerve Repair

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-09-24
Completion:: 2025-12-04

Conditions

Peripheral Nerve Injuries

Interventions

BIOLOGICAL

No Results Yet