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Early Life Stress and Depression: Molecular and Functional Imaging

NCT04713722 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 160

Last updated 2025-12-12

No results posted yet for this study

Summary

Severe childhood adversity accounts for a large portion of psychiatric illness, and an increased risk for major depressive disorder (MDD). For some individuals, childhood adversity has negative psychological and medical consequences; others preserve mental and physical health despite such experiences (they are resilient). In spite of this, little is known about the neurobiological mechanisms related to childhood adversity, especially oxidative stress abnormalities in the brain. To fill this gap, this study combines functional, structural, and molecular imaging approaches to examine the role of oxidative stress abnormalities related to childhood adversity.

Conditions

Sponsors & Collaborators

  • Mclean Hospital

    lead OTHER

Principal Investigators

  • Diego Pizzagalli, PhD · Mclean Hospital

Eligibility

Min Age
20 Years
Max Age
32 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-02-01
Primary Completion
2026-06-30
Completion
2026-06-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04713722 on ClinicalTrials.gov