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Study of COVID-19 Outbreak in Hospital Departments of Bamako, Mali

NCT04710316 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 450

Last updated 2025-12-12

No results posted yet for this study

Summary

The new coronavirus known as SARS-Cov-2 (severe acute respiratory syndrome -coronavirus 2) was first reported in December 2019 and rapidly became a public health emergency. The COVID-19 pandemic is now affecting sensitive regions with fragile health care systems, such as South America and Africa. Caregivers, in the front line of Covid19 patient management, may accidentally become infected and a source of infection during the incubation phase or in case of asymptomatic infection.

The objectives of this project are thus i) to assess SARS-Cov-2 spread over the hospital departments of Bamako by carrying out a systematic molecular screening of patients and caregivers, ii) to evaluate the feasibility of Point-Of-Care molecular assays in Mali and iii) to estimate the immunity acquired from SARS-Cov-2 among health workers through serological testing, allowing also the assessment of asymptomatic caregiver rate and absence of re-infection among the immunized caregivers. Finally, iv) variability of the virus over time and spread of different variants around the world will be studied by sequencing the viral genome.

Conditions

  • Covid19

Interventions

DIAGNOSTIC_TEST

Serological screening

Serological screening of caregivers at D0, M1, M2, M3 (anti-nucleocapsid antibodies).

DIAGNOSTIC_TEST

SARS-CoV-2 screening by molecular biology

SARS-CoV-2 RT-PCR in nasopharyngeal swab targeting 2 regions of the viral genome

Sponsors & Collaborators

  • Institut National de la Santé Et de la Recherche Médicale, France

    lead OTHER_GOV

Principal Investigators

  • Almoustapha Issiaka MAIGA · SEREFO/UCRC, FMOS - University Hospital Gabriel Toure, Bamako, Mali

  • Eve Todesco · APHP - Sorbonne university

Study Design

Allocation
NON_RANDOMIZED
Purpose
SCREENING
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-02-15
Primary Completion
2022-04-30
Completion
2022-09-30

Countries

  • Mali

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04710316 on ClinicalTrials.gov