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Genetic Studies of Strabismus, Nystagmus, and Associated Disorders

NCT04770519 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2025-12-12

No results posted yet for this study

Summary

Strabismus (misalignment of the eyes) often runs in families. In this study, the investigators are looking for genetic variants associated with strabismus and nystagmus. Three types of subects will be enrolled: (1) Families with at least 3 members with strabismus, (2) individuals with infantile esotropia and their parents and siblings, and (3) individuals with infantile nystagmus and their parents. Whole exome and/or whole genome sequencing will be used to identify genetic variants shared by family members with strabismus and to identify genetic causes of nystagmus.

Conditions

  • Strabismus
  • Nystagmus, Congenital

Interventions

GENETIC

whole genome sequencing or whole exome sequencing

Whole genome sequencing or whole exome sequencing will be performed for all enrolled participants.

Sponsors & Collaborators

Principal Investigators

  • Mary Whitman, MD/PhD · Assistant Professor

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-09-03
Primary Completion
2030-12-31
Completion
2030-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04770519 on ClinicalTrials.gov