Clinical Trials Updated in 2025

NCT05478252 | COMPLETED | PHASE3

388 participants

A Research Study to Compare Two Semaglutide Medicines in People With Type 2 Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-08-03
Completion:: 2023-08-09

Conditions

Diabetes Mellitus, Type 2

Interventions

DRUG

Results Available

NCT05458128 | COMPLETED | PHASE3

119 participants

A Long-Term Safety and Effectiveness Study to Evaluate Pitolisant in Adult Patients With Idiopathic Hypersomnia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-08-19
Completion:: 2025-10-01

Conditions

Idiopathic Hypersomnia
Excessive Daytime Sleepiness

Interventions

DRUG

No Results Yet

NCT05450432 | RECRUITING | PHASE4

100 participants

Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-10-13
Completion:: 2026-06-01

Conditions

Major Depressive Disorder

Interventions

DRUG

No Results Yet

NCT05444556 | COMPLETED | PHASE1

113 participants

A Study of Imlunestrant (LY3484356) in Female Healthy Participants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-07-07
Completion:: 2022-11-02

Conditions

Healthy

Interventions

DRUG

Results Available

NCT05433584 | ACTIVE_NOT_RECRUITING | PHASE4

780 participants

A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-08-01
Completion:: 2025-10-21

Conditions

Type 2 Diabetes

Interventions

DRUG

No Results Yet

NCT05421689 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

66 participants

Autologous Muscle Derived Cells for Treatment of Tongue Dysphagia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-05-26
Completion:: 2026-12-31

Conditions

Oropharyngeal Dysphagia

Interventions

BIOLOGICAL
OTHER

No Results Yet

NCT05392114 | ACTIVE_NOT_RECRUITING | PHASE3

154 participants

A Study to Assess the Long-Term Safety and Efficacy of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-07-13
Completion:: 2026-12-31

Conditions

Hereditary Angioedema

Interventions

DRUG

No Results Yet

NCT05389436 | COMPLETED | NA

86 participants

Outpatient Versus Inpatient Surgery for Ankle Fractures

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-05-23
Completion:: 2025-03-20

Conditions

Ankle Fractures
Orthopedic Procedures
Surgical Procedures
Inpatient

Interventions

PROCEDURE

No Results Yet

NCT05354232 | RECRUITING | NA

60 participants

Home-based Transcranial Direct Current Stimulation (tDCS) for Treatment of Attention-deficit/Hyperactivity Disorder (ADHD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-07-01
Completion:: 2026-05-31

Conditions

Attention Deficit Disorder
Attention Deficit Disorder With Hyperactivity

Interventions

DEVICE

No Results Yet

NCT05299944 | COMPLETED | PHASE2

126 participants

Reducing Pain and Opioid Use With CBD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-03-08
Completion:: 2025-07-29

Conditions

Opioid Use Disorder

Interventions

DRUG

No Results Yet

NCT05224544 | COMPLETED | NA

43 participants

Intermittent Catheterisation on the Bladder Mucosa of Healthy Volunteers With a Prototype Micro Hole Zone Catheter

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-01-31
Completion:: 2022-03-31

Conditions

Urinary Incontinence

Interventions

DEVICE

Results Available

NCT05185843 | ACTIVE_NOT_RECRUITING | PHASE3

24 participants

A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRX) Administered to Adults With Familial Chylomicronemia Syndrome (FCS) Previously Treated With Volanesorsen

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-02-25
Completion:: 2027-06-30

Conditions

Familial Chylomicronemia Syndrome

Interventions

DRUG

No Results Yet

NCT05182073 | COMPLETED | PHASE1

31 participants

FT576 in Subjects With Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-11-10
Completion:: 2024-09-20

Conditions

Multiple Myeloma
Myeloma

Interventions

DRUG

No Results Yet

NCT05168774 | COMPLETED | PHASE1/PHASE2

20 participants

FRDA Investigator Initiated Study (IIS) With Elamipretide

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-03-03
Completion:: 2024-06-25

Conditions

Friedreich Ataxia

Interventions

DRUG

Results Available

NCT05130450 | ACTIVE_NOT_RECRUITING | PHASE3

60 participants

A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial Chylomicronemia Syndrome (FCS)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-11-18
Completion:: 2028-02-29

Conditions

Familial Chylomicronemia Syndrome

Interventions

DRUG

No Results Yet

NCT05122767 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

92 participants

Rifapentine and Isoniazid TB Preventive Therapy (3HP) for Children Taking Dolutegravir-based Antiretroviral Treatment (DOLPHIN KIDS)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2023-05-24
Completion:: 2025-07-04

Conditions

Tuberculosis
HIV

Interventions

DRUG

No Results Yet

NCT05122026 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

252 participants

Safety and Tolerability of 1 Month Daily (1HP) and 3 Months Weekly (3HP) Isoniazid and Rifapentine With Pharmacokinetics of Dolutegravir (DTG) in Pregnant People With HIV

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2024-01-17
Completion:: 2025-10-24

Conditions

HIV Seropositivity
Pregnancy
Tuberculosis Infection

Interventions

DRUG

No Results Yet

NCT05118490 | ACTIVE_NOT_RECRUITING | PHASE4

1000 participants

Comparing Treatment Completion Of Daily Rifapentine & Isoniazid For One Month (1HP) To Weekly High Dose Rifapentine & Isoniazid For 3 Months (3HP) In Persons Living With HIV and in Household Contacts of Recently Diagnosed Tuberculosis Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2023-07-19
Completion:: 2025-07-11

Conditions

HIV Seropositivity
Tuberculosis
Household Contact

Interventions

DRUG

No Results Yet

NCT05018728 | TERMINATED | PHASE2

22 participants

The Effect of Voxelotor on Cerebral Hemodynamic Response in Children With Sickle Cell Anemia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-03-28
Completion:: 2024-10-22

Conditions

Sickle Cell Anemia in Children

Interventions

DRUG

No Results Yet

NCT05008809 | RECRUITING | PHASE3

507 participants

Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-12-06
Completion:: 2027-11-30

Conditions

Colorectal Cancer

Interventions

DRUG

No Results Yet

NCT04998370 | COMPLETED

366 participants

Cerebrospinal Fluid Hemoglobin to Monitor for Aneurysmal Subarachnoid Hemorrhage Related Secondary Brain Injury

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-08-18
Completion:: 2024-09-30

Conditions

Subarachnoid Hemorrhage, Aneurysmal
Vasospasm
Delayed Cerebral Ischemia
Delayed Ischemic Neurological Deficit

No Results Yet

NCT04976621 | COMPLETED | NA

46 participants

ACTIVE: Activity Therapy to Increase Veteran Engagement

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2022-02-15
Completion:: 2024-04-16

Conditions

Traumatic Brain Injury

Interventions

BEHAVIORAL
OTHER

Results Available

NCT04961619 | COMPLETED

39 participants

Adjuvant Dabrafenib and Trametinib Treatment in Patients With Completely Resected High-risk Stage III Melanoma.

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-12-01
Completion:: 2024-12-05

Conditions

Melanoma

Interventions

DRUG

No Results Yet

NCT04940078 | COMPLETED | PHASE1

40 participants

A Research Study to Compare Blood Levels of Cagrilintide and Semaglutide After Combined Versus Separate Injections in People With Overweight or Obesity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-07-07
Completion:: 2022-01-19

Conditions

Obesity & Overweight

Interventions

DRUG

No Results Yet

NCT04939519 | COMPLETED | NA

65300 participants

SCALE-UP Utah: Community-Academic Partnership to Address COVID-19 Vaccination Rates Among Utah Community Health Centers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-03-29
Completion:: 2022-06-17

Conditions

Covid19

Interventions

BEHAVIORAL

Results Available

NCT04918030 | COMPLETED | NA

1586 participants

STaged Interventional Strategies for Acute ST-seGment Elevation Myocardial Infarction Patient With Multi-vessel Disease（STAGED）

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-02-11
Completion:: 2025-02-01

Conditions

STEMI
Multi Vessel Coronary Artery Disease
Percutaneous Coronary Intervention
AMI Patients With Multivessel Disease, Staged PCI

Interventions

PROCEDURE

No Results Yet

NCT04913753 | COMPLETED | NA

2200 participants

Relevance of the Urine Bacterial Culture Performed Before Double J Ablation for Post-operative Urinary Tract Infection Prevention

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-06-10
Completion:: 2025-12-03

Conditions

Urinary Infection

Interventions

PROCEDURE

No Results Yet

NCT04862949 | COMPLETED

131 participants

Organ-specific Responses to Atezolizumab Plus Bevacizumab in Advanced HCC

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-05-01
Completion:: 2022-12-31

Conditions

Advanced Hepatocellular Carcinoma

Interventions

DRUG

Results Available

NCT04846881 | COMPLETED | PHASE3

611 participants

Clinical Trial of Iclepertin Effect on Cognition and Functional Capacity in Schizophrenia (CONNEX-2)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-08-24
Completion:: 2024-10-18

Conditions

Schizophrenia

Interventions

DRUG

Results Available

NCT04771078 | AVAILABLE

Expanded Access Protocol (EAP) for Participants Receiving Idecabtagene Vicleucel That is Nonconforming for Commercial Release

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-12-12

Conditions

Multiple Myeloma

Interventions

BIOLOGICAL

No Results Yet

NCT04770519 | RECRUITING

400 participants

Genetic Studies of Strabismus, Nystagmus, and Associated Disorders

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-09-03
Completion:: 2030-12-31

Conditions

Strabismus
Nystagmus, Congenital

Interventions

GENETIC

No Results Yet

NCT04745754 | ACTIVE_NOT_RECRUITING | NA

2450 participants

The Engaging Primary Care in Cancer Survivorship (EPICS) Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-09-21
Completion:: 2026-02-28

Conditions

Breast Cancer
Colorectal Cancer

Interventions

OTHER

No Results Yet

NCT04722887 | COMPLETED | PHASE1/PHASE2

17 participants

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-08-13
Completion:: 2025-08-01

Conditions

Alpha1-Antitrypsin Deficiency

Interventions

BIOLOGICAL

No Results Yet

NCT04713722 | RECRUITING

160 participants

Early Life Stress and Depression: Molecular and Functional Imaging

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-02-01
Completion:: 2026-06-30

Conditions

Depression
Trauma, Psychological

No Results Yet

NCT04710316 | COMPLETED | NA

450 participants

Study of COVID-19 Outbreak in Hospital Departments of Bamako, Mali

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-02-15
Completion:: 2022-04-30

Conditions

Covid19

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04706507 | TERMINATED | PHASE3

205 participants

Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients With Acute Respiratory Failure and Sepsis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-06-29
Completion:: 2024-10-25

Conditions

Acute Respiratory Failure

Interventions

DRUG

Results Available

NCT04678960 | COMPLETED | NA

250 participants

Preventing Opioid Use Among Justice-involved Youth as They Transition to Adulthood Leveraging Safe Adults (LeSA)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-02-15
Completion:: 2025-09-30

Conditions

Opioid Use
Substance Use

Interventions

BEHAVIORAL

No Results Yet

NCT04610697 | RECRUITING | NA

30 participants

Cognitive Remediation in Forensic Mental Health Care

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2020-02-10
Completion:: 2026-02-10

Conditions

Psychotic Disorders
ADHD
TBI (Traumatic Brain Injury)
Aggression
Substance Use Disorders
Violence
Cognitive Dysfunction
Anxiety
Depression
Schizophrenia
Offenders
Antisocial

Interventions

BEHAVIORAL

No Results Yet

NCT04603183 | COMPLETED | PHASE2

162 participants

ABemaciclib, ET ± paclItaxel in aGgressive HR+/HER2- MBC trIaL

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-06-02
Completion:: 2024-06-30

Conditions

Breast Cancer Metastatic

Interventions

DRUG

No Results Yet

NCT04552600 | COMPLETED | PHASE1/PHASE2

100 participants

Study to Evaluate Clinical Efficacy and Safety of Nuvastatic™ - C5OSEW5050ESA in Diabetic Retinopathy.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-09-01
Completion:: 2022-08-10

Conditions

Diabetic Retinopathy

Interventions

DRUG
OTHER

No Results Yet