Clinical Trials Updated in 2025

NCT04102189 | COMPLETED | PHASE3

201 participants

A Research Study on How Well Semaglutide Works in Adolescents With Overweight or Obesity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2019-10-07
Completion:: 2022-03-25

Conditions

Overweight
Obesity

Interventions

DRUG
OTHER

Results Available

NCT04087655 | RECRUITING | NA

25 participants

Microvascular Dysfunction in Obesity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2019-11-20
Completion:: 2026-11-19

Conditions

Obesity
Endothelial Dysfunction

Interventions

BEHAVIORAL

No Results Yet

NCT04063384 | COMPLETED | NA

60 participants

Acute Alcohol Response In Bipolar Disorder: a fMRI Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2019-07-22
Completion:: 2024-03-31

Conditions

Bipolar Disorder
Alcohol Drinking
Alcohol Use Disorder

Interventions

OTHER

Results Available

NCT04026711 | COMPLETED | PHASE1

47 participants

MitoQ for the Treatment of Metabolic Dysfunction in Asthma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2020-01-01
Completion:: 2024-03-31

Conditions

Asthma
Obesity

Interventions

DRUG

Results Available

NCT04013061 | COMPLETED | NA

378 participants

Impact of a Pharmacist-anesthesiologist Collaboration During Anesthesia Consultation on Prevention of Perioperative Medication Errors of Patients in Programmed Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2020-02-25
Completion:: 2021-08-20

Conditions

Surgical Procedures, Operative

Interventions

OTHER

No Results Yet

NCT04004871 | COMPLETED | PHASE2

60 participants

Induction Chemotherapy With Nab-paclitaxel, Cisplatin and Fluorouracil for Locoregionally Advanced Nasopharyngeal Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2019-03-28
Completion:: 2022-03-29

Conditions

Nasopharyngeal Carcinoma
Nasopharyngeal Cancer
Nasopharynx Cancer

Interventions

DRUG
RADIATION

No Results Yet

NCT03983837 | COMPLETED | PHASE2

3 participants

Elemental Diet for Treatment of Inflammatory Bowel Disease in Patients With Chronic Granulomatous Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2021-06-23
Completion:: 2025-11-18

Conditions

Chronic Granulomatous Disease
Inflammatory Bowel Disease

Interventions

OTHER

No Results Yet

NCT03952637 | RECRUITING | PHASE1/PHASE2

54 participants

A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2019-08-19
Completion:: 2028-01-01

Conditions

Lysosomal Diseases
Gangliosidosis
GM1

Interventions

BIOLOGICAL
PROCEDURE
DRUG
DIAGNOSTIC_TEST
OTHER
BEHAVIORAL

No Results Yet

NCT03924869 | TERMINATED | PHASE3

448 participants

Efficacy and Safety Study of Stereotactic Body Radiotherapy (SBRT) With or Without Pembrolizumab (MK-3475) in Adults With Unresected Stage I or II Non-Small Cell Lung Cancer (NSCLC) (MK-3475-867/KEYNOTE-867)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2019-06-25
Completion:: 2024-06-11

Conditions

Non-Small Cell Lung Cancer

Interventions

RADIATION
BIOLOGICAL
DRUG

Results Available

NCT03914326 | COMPLETED | PHASE3

9651 participants

A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2019-06-17
Completion:: 2024-08-23

Conditions

Diabetes Mellitus, Type 2

Interventions

DRUG

Results Available

NCT03833921 | RECRUITING | PHASE2

130 participants

Evaluation of Response to Abiraterone/Prednisone by Race/Ethnicity and Other Factors in Metastatic Hormone Naive Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2019-05-23
Completion:: 2028-11-30

Conditions

Prostate Cancer Metastatic
Prostate Cancer

Interventions

DRUG

No Results Yet

NCT03826524 | RECRUITING | PHASE4

3790 participants

Epinephrine Dose: Optimal Versus Standard Evaluation Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2023-05-24
Completion:: 2027-12-31

Conditions

Cardiac Arrest, Out-Of-Hospital
Sudden Cardiac Arrest
Ventricular Fibrillation
Ventricular Tachycardia-Pulseless

Interventions

DRUG

No Results Yet

NCT03780660 | COMPLETED

68 participants

Diagnostic Accuracy of the Central Venous Pressure (CVP) Variation to Predict Fluid Responsiveness in Spontaneously Breathing Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-11
Start Date:: 2019-03-05
Completion:: 2021-09-15

Conditions

Breathing

No Results Yet

NCT03774082 | COMPLETED | PHASE2

46 participants

Activity, Safety and Pharmacokinetics in Pediatric Subjects With Moderate and Severe Chronic Graft vs. Host Disease After Allogeneic Stem Cell Transplant

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2020-05-20
Completion:: 2022-02-25

Conditions

Graft vs Host Disease

Interventions

DRUG

Results Available

NCT03755791 | ACTIVE_NOT_RECRUITING | PHASE3

837 participants

Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2018-06-10
Completion:: 2021-11-30

Conditions

Hepatocellular Carcinoma

Interventions

DRUG

Results Available

NCT03732898 | COMPLETED | NA

15 participants

Coordinated Reset Deep Brain Stimulation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2019-01-13
Completion:: 2025-11-12

Conditions

Parkinson's Disease (PD)

Interventions

DEVICE

No Results Yet

NCT03708770 | COMPLETED | NA

32 participants

everlinQ Endovascular Access System Enhancements (EASE) Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2015-07-27
Completion:: 2017-06-19

Conditions

Chronic Kidney Diseases

Interventions

DEVICE

Results Available

NCT03708562 | COMPLETED | NA

24 participants

everlinQ Endovascular Access Systems Enhancements (EASE-2) Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2017-10-16
Completion:: 2018-12-12

Conditions

Chronic Kidney Diseases

Interventions

DEVICE

Results Available

NCT03655769 | ACTIVE_NOT_RECRUITING | NA

16 participants

fMRI Analysis of Aging and Awareness in Conditioning

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2010-11-09
Completion:: 2026-12-31

Conditions

Transcranial Direct Current Stimulation

Interventions

DEVICE

No Results Yet

NCT03651362 | COMPLETED

46 participants

Linking Optic Nerve MRI and the Retinal Axonal Loss After Optic Neuritis

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-11
Start Date:: 2016-02-29
Completion:: 2020-03-11

Conditions

Optic Neuritis

No Results Yet

NCT03599635 | COMPLETED | PHASE4

112 participants

Pec Infiltration With Liposomal Bupivacaine for Breast Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2018-07-01
Completion:: 2024-07-01

Conditions

Acute Pain

Interventions

DRUG

Results Available

NCT03594994 | COMPLETED | NA

31 participants

Metabolic Effects of Sleep Extension in People With Obesity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2018-10-29
Completion:: 2024-07-15

Conditions

Insulin Resistance
Obesity

Interventions

BEHAVIORAL

Results Available

NCT03570957 | COMPLETED | PHASE1

75 participants

A Clinical Pharmacology Study of MT-2990 in Seasonal Allergic Rhinitis Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2018-07-17
Completion:: 2018-12-27

Conditions

Seasonal Allergic Rhinitis

Interventions

DRUG

No Results Yet

NCT03564873 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

28 participants

Omacetaxine + Azacitidine in Untreated Patients With High Grade MDS

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2018-09-17
Completion:: 2025-10-07

Conditions

High Grade Myelodysplastic Syndromes

Interventions

DRUG

No Results Yet

NCT03556228 | RECRUITING | PHASE1/PHASE2

242 participants

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2018-06-08
Completion:: 2027-12-31

Conditions

Head and Neck Carcinoma
Adenoid Cystic Carcinoma
Lung Cancer
Non-Small Cell Lung Cancer
Pancreatic Cancer
Mesothelioma
Esophageal Cancer
Any Solid Tumors Progressed After a Prior Immunotherapy
Head and Neck Squamous Cell Carcinoma
Head and Neck Squamous Cell Carcinoma HNSCC
Salivary Gland Carcinomas
Head and Neck Cancers - Salivary Gland
Head and Neck Cancers - Nasopharyngeal
Head and Neck Cancers - Throat
Small Cell Lung Cancer ( SCLC )
Lung Cancer (Locally Advanced or Metastatic)
Head and Neck Cancers - Tonsils
Head and Neck Cancers Hypopharynx
Head and Neck Cancers Larynx
Head and Neck Cancers Lip
Head and Neck Cancers Nasopharynx
Head and Neck Cancers Oral Cavity
Head and Neck Cancers
Head and Neck Cancers Oropharynx
Head and Neck Cancers Trachea

Interventions

DRUG

No Results Yet

NCT03541330 | TERMINATED | NA

7 participants

Information and Accompaniment of Siblings Following the Announcement of a Cancer in Pediatric Hematology.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2018-10-22
Completion:: 2019-04-01

Conditions

Malignant Haemopathy

Interventions

OTHER

No Results Yet

NCT03528213 | COMPLETED | PHASE2/PHASE3

59 participants

Utility of Sodium Lactate Infusion During Septic Shock

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2019-10-04
Completion:: 2023-02-21

Conditions

Septic Shock

Interventions

DRUG

No Results Yet

NCT03453606 | TERMINATED | NA

188 participants

Respiratory Rehabilitation for Patients With Chronic Obstructive Pulmonary Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2018-10-24
Completion:: 2022-09-16

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

OTHER

No Results Yet

NCT03449901 | COMPLETED | PHASE2

98 participants

ADI-PEG 20 in Combination With Gemcitabine and Docetaxel for the Treatment of Soft Tissue Sarcoma, Osteosarcoma, Ewing's Sarcoma, and Small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2018-05-09
Completion:: 2022-07-08

Conditions

Soft Tissue Sarcoma

Interventions

DRUG
PROCEDURE

Results Available

NCT03401489 | TERMINATED | NA

120 participants

PACESETTER: Program to Avoid Cerebrovascular Events Through Systematic Electronic Tracking and Tailoring of an Eminent Risk-factor

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2020-07-14
Completion:: 2024-02-28

Conditions

Blood Pressure
Hypertension
Mhealth

Interventions

DEVICE

Results Available

NCT03323502 | COMPLETED | NA

47396 participants

Aligning Patient Preferences: a Role Offering Alzheimer's Patients, Caregivers, and Healthcare Providers Education and Support

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2020-02-01
Completion:: 2022-08-31

Conditions

Alzheimer Disease
Dementia

Interventions

BEHAVIORAL
OTHER

Results Available

NCT03311503 | RECRUITING | PHASE1/PHASE2

12 participants

Phase I/II Trial of Lentiviral Gene Transfer for SCID-X1 With Low Dose Targeted Busulfan Conditioning

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2018-02-26
Completion:: 2028-01-01

Conditions

Severe Combined Immunodeficiency, X Linked
Gene Therapy

Interventions

BIOLOGICAL

No Results Yet

NCT03280251 | COMPLETED | PHASE2

31 participants

Methylphenidate and Cognitive Training in Elderly

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2018-09-19
Completion:: 2020-03-11

Conditions

Healthy Volunteers

Interventions

DRUG
OTHER

No Results Yet

NCT03199300 | ACTIVE_NOT_RECRUITING

20 participants

Investigating Cardiovascular Adverse Events Related to Cancer Treatment

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-11
Start Date:: 2017-12-12
Completion:: 2025-02-06

Conditions

Toxicity Due to Chemotherapy
Cardiovascular Morbidity
Cancer, Treatment-Related

Interventions

DRUG

No Results Yet

NCT03150173 | COMPLETED | PHASE2

97 participants

Onsite Buprenorphine Treatment at Syringe Exchange Programs

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2019-01-02
Completion:: 2023-10-11

Conditions

Opiate Addiction

Interventions

BEHAVIORAL
DRUG

Results Available

NCT03140254 | COMPLETED | PHASE2

145 participants

Evaluating Safety and Effectiveness of Octenidine Dihydrochloride

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2016-09-30
Completion:: 2017-03-17

Conditions

Preoperative Skin Preparation

Interventions

DRUG

Results Available

NCT03109847 | TERMINATED | PHASE2

13 participants

Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2017-01-05
Completion:: 2020-12-29

Conditions

Thyroid

Interventions

DRUG
OTHER

Results Available

NCT03043924 | COMPLETED | NA

52 participants

Functional Study of the Hypothalamus in Magnetic Resonance Imaging (MRI) in Polycystic Ovary Syndrome (PCOS)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2017-09-26
Completion:: 2022-04-15

Conditions

Polycystic Ovary Syndrome

Interventions

DRUG

No Results Yet

NCT03012360 | TERMINATED | PHASE4

103 participants

Antimicrobial Treatment in Patients With Ventilator-associated Tracheobronchitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-11
Start Date:: 2018-02-08
Completion:: 2024-07-07

Conditions

Mechanical Ventilation Complication
Critical Illness

Interventions

DRUG

No Results Yet

NCT02938858 | ACTIVE_NOT_RECRUITING

400 participants

French Registry of First-line Treatment of Acute Promyelocytic Leukemia

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-11
Start Date:: 2015-10-31
Completion:: 2026-07-31

Conditions

Acute Promyelocytic Leukemia

No Results Yet