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Functional Study of the Hypothalamus in Magnetic Resonance Imaging (MRI) in Polycystic Ovary Syndrome (PCOS)

NCT03043924 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2025-12-11

No results posted yet for this study

Summary

The aim to evaluate whether activation of the hypothalamic-pituitary-gonadal axis in PCOS is associated with transient microstructural and metabolic changes in the female hypothalamus using MRI approaches to assess water diffusion and measure proton magnetic resonance spectra.

Conditions

  • Polycystic Ovary Syndrome

Interventions

DRUG

Cyproterone Acetate + estradiol

PCOS will receive: 50mg cyproterone acetate (Androcur®) in combination with p.o. 2mg estradiol daily

DRUG

Levonorgestrel, Ethinyl Estradiol 0.1-0.02Mg Oral Tablet

Healthy volunteers receive combined oral contraceptive (COC) consisting 0.02 mg ethinylestradiol and 0.1mg of progestins (Leeloo Gé®)

Sponsors & Collaborators

  • National Research Agency, France

    collaborator OTHER

  • University Hospital, Lille

    lead OTHER

Principal Investigators

  • Didier Dewailly, MD,PhD · University Hospital, Lille

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
19 Years
Max Age
30 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-09-26
Primary Completion
2022-04-15
Completion
2022-04-15

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03043924 on ClinicalTrials.gov