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Epinephrine Dose: Optimal Versus Standard Evaluation Trial

NCT03826524 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 3790

Last updated 2025-12-11

No results posted yet for this study

Summary

The objective of this randomized controlled trial is to evaluate the effectiveness of a low cumulative dose of epinephrine compared to a standard cumulative dose of epinephrine during resuscitation from ventricular fibrillation (VF) or ventricular tachycardia (VT) in adult out-of-hospital cardiac arrest (OHCA) patients.

Conditions

  • Cardiac Arrest, Out-Of-Hospital
  • Sudden Cardiac Arrest
  • Ventricular Fibrillation
  • Ventricular Tachycardia-Pulseless

Interventions

DRUG

Epinephrine

Epinephrine 1mg 1:10000 (10cc) per dose

Sponsors & Collaborators

  • Canadian Institutes of Health Research (CIHR)

    collaborator OTHER_GOV

  • Pfizer

    collaborator INDUSTRY

  • Unity Health Toronto

    lead OTHER

Principal Investigators

  • Paul Dorian, MD, MSc · Unity Health Toronto

  • Steve Lin, MD, MSc · Unity Health Toronto

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-05-24
Primary Completion
2027-12-31
Completion
2028-12-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03826524 on ClinicalTrials.gov