Clinical Trials Updated in 2025

NCT06425406 | RECRUITING | NA

48 participants

Application of HFNC for the Prevention of Hypoxemia During Perioperative Anesthetic-induced Intubation in Children: A Randomized Controlled Clinical Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2024-06-15
Completion:: 2025-11-30

Conditions

High-flow Nasal Cannula
Children
Pre-oxygenation

Interventions

DEVICE

No Results Yet

NCT06415045 | COMPLETED | PHASE1

18 participants

A Study in Healthy People to Test How BI 1015550 is Taken up in the Body When Given With or Without Food

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2024-05-28
Completion:: 2024-07-24

Conditions

Healthy

Interventions

DRUG

Results Available

NCT06408870 | COMPLETED | PHASE1

64 participants

A Study in Healthy People to Compare How 2 Different Low Dose Formulations of BI 1015550 Are Taken up in the Body

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2024-06-06
Completion:: 2024-08-28

Conditions

Healthy

Interventions

DRUG

Results Available

NCT06393127 | COMPLETED | PHASE1

64 participants

A Study in Healthy People to Compare How 2 Different High Dose Formulations of BI 1015550 Are Taken up in the Body

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2024-06-04
Completion:: 2024-09-10

Conditions

Healthy

Interventions

DRUG

Results Available

NCT06357962 | TERMINATED | NA

8 participants

Semi-permanent Acupuncture Effect on Cervical Ripening

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2024-05-22
Completion:: 2025-03-16

Conditions

Pregnancy Complications

Interventions

OTHER

No Results Yet

NCT06295549 | TERMINATED | PHASE1

11 participants

Targeting CD19/CD20 Dual-targeted Cell in Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2024-04-11
Completion:: 2025-06-11

Conditions

Relapsed and Refractory B-cell Non-Hodgkin Lymphoma

Interventions

BIOLOGICAL

No Results Yet

NCT06281444 | COMPLETED | NA

72 participants

Effectiveness of Radial Extracorporeal Shock Wave Therapy in Patients With Knee Osteoarthritis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2024-01-01
Completion:: 2025-09-15

Conditions

Knee Osteoarthritis

Interventions

DEVICE

No Results Yet

NCT06277492 | COMPLETED | PHASE1

83 participants

A First-In-Human Study of Single and Multiple Ascending Doses of Oral SUL-238 in Healthy Subjects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2024-02-19
Completion:: 2025-07-11

Conditions

Healthy Subjects

Interventions

DRUG

No Results Yet

NCT06248008 | COMPLETED | PHASE3

240 participants

A Study to Evaluate Safety of ASC40 Tablets in Patients With Moderate to Severe Acne Vulgaris

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2024-04-18
Completion:: 2025-11-12

Conditions

Acne

Interventions

DRUG

No Results Yet

NCT06243445 | COMPLETED

22 participants

Echocardiography With Bubble Test for Tip Location of Central Venous Catheters

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-01
Start Date:: 2024-02-01
Completion:: 2024-04-01

Conditions

Cardiac Surgery Patient

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06221059 | COMPLETED | PHASE2

181 participants

Efficacy and Safety of HRS-1780 Tablets and Henagliflozin Proline Tablets in Patients With Chronic Kidney Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2024-03-02
Completion:: 2025-03-05

Conditions

Chronic Kidney Disease

Interventions

DRUG

No Results Yet

NCT06201234 | RECRUITING | PHASE2

176 participants

Evaluating the Addition of Elacestrant (Oral SERD) to Olaparib (PARP-inhibitor) in Patients With Advanced/Metastatic HR+/HER2- Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2024-12-13
Completion:: 2028-12-31

Conditions

Hormone Receptor Positive HER-2 Negative Breast Cancer
Advanced or Metastatic Breast Cancer
BRCA1 Mutation
BRCA2 Mutation

Interventions

DRUG

No Results Yet

NCT06139302 | COMPLETED | PHASE1

12 participants

A Study to Test How Different Doses of Nerandomilast (BI 1015550) Are Taken up in the Body of Healthy Japanese Men

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-12-20
Completion:: 2024-02-07

Conditions

Healthy

Interventions

DRUG

Results Available

NCT06136390 | COMPLETED | NA

42 participants

OXYMIND: Oxytocin-augmented Group Psychotherapy for Patients With Schizophrenia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-09-30
Completion:: 2024-12-30

Conditions

Schizophrenia Spectrum Disorders

Interventions

OTHER

No Results Yet

NCT06130670 | COMPLETED | NA

54 participants

Clinical Efficacy and Safety of Dexmedetomidine as an Adjuvant in Quadratus Lumborum Versus Epidural Block in Postoperative Lower Abdominal Cancer Surgeries

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2024-04-20
Completion:: 2024-12-31

Conditions

To Compare Efficacy of Dexmedetomidine in Bilateral Quadratus Lumborum vs Lumbar Epidural Blocks on Analgesia After Major Lower Abdominal Surgery

Interventions

OTHER

No Results Yet

NCT06116578 | WITHDRAWN | PHASE2

0 participants

Study Evaluating Pembrolizumab +/- Olaparib in TLS Positive Selected Resectable STS Followed by Adjuvant Pembrolizumab

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2025-01-01
Completion:: 2027-07-31

Conditions

Cancer

Interventions

DRUG

No Results Yet

NCT06115967 | COMPLETED | PHASE1

40 participants

A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of Subcutaneous AZD6912 in Healthy Participants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-11-15
Completion:: 2025-10-16

Conditions

Rheumatoid Arthritis

Interventions

DRUG

No Results Yet

NCT06094205 | RECRUITING | NA

2 participants

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-10-16
Completion:: 2027-08-31

Conditions

Anarthria
Dysarthria
Tetraplegia
Spinal Cord Injuries
Amyotrophic Lateral Sclerosis
Brain Stem Infarctions
Locked-in Syndrome
Muscular Dystrophies

Interventions

DEVICE

No Results Yet

NCT06081881 | RECRUITING

100 participants

Chronic Thromboembolic Pulmonary Hypertension After Pulmonary Embolism

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-01
Start Date:: 2025-01-01
Completion:: 2026-10-01

Conditions

Chronic Thromboembolic Pulmonary Hypertension

No Results Yet

NCT06050434 | TERMINATED

7 participants

Prospective Study to Evaluate Patient Reported Outcomes (PRO) During Rechallenge With Trabectedin in Sarcoma Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-10-31
Completion:: 2024-07-30

Conditions

Soft Tissue Sarcoma

No Results Yet

NCT06018025 | COMPLETED

38 participants

NDPH Biomarker Study in Children and Adolescents

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-01
Start Date:: 2024-04-15
Completion:: 2025-05-29

Conditions

New Persistent Daily Headache

Interventions

DRUG

No Results Yet

NCT06009809 | RECRUITING

92 participants

Blood Velocity Variation in Right Renal and Superior Mesenteric Arteries During Cardio-pulmonary Bypass

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-01
Start Date:: 2022-02-15
Completion:: 2025-12-31

Conditions

Heart Surgical Procedure

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06007092 | RECRUITING | PHASE1/PHASE2

24 participants

Therapeutic Vaccine in Patients With Human Papillomavirus HPV-positive Oropharyngeal Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-07-31
Completion:: 2025-11-30

Conditions

Head and Neck Carcinoma
Adult Disease

Interventions

BIOLOGICAL

No Results Yet

NCT05975307 | ACTIVE_NOT_RECRUITING | PHASE2

71 participants

Treating Muscle-invasive Bladder Cancer With A Non-surgical Method Consisting of Anti-PD-1 Therapy and Chemoradiation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-12-01
Completion:: 2025-12-31

Conditions

Muscle-Invasive Bladder Carcinoma
Programmed Cell Death Protein 1 Inhibitor
Radiotherapy

Interventions

DRUG
RADIATION

No Results Yet

NCT05913973 | COMPLETED | PHASE1

105 participants

Study of the Plasmodium Vivax Transmission-blocking Vaccine Pvs230D1-EPA/Matrix-M to Assess Safety, Immunogenicity, and Transmission-blocking Activity in Healthy Malaria-naive Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-08-04
Completion:: 2025-11-12

Conditions

Malaria

Interventions

DRUG

No Results Yet

NCT05910385 | COMPLETED | NA

140 participants

TUbal LIgation Per Differents Endoscopic Routes and Sexuality (TULIPES)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2022-05-23
Completion:: 2025-11-18

Conditions

Gynecologic Surgery

Interventions

PROCEDURE

No Results Yet

NCT05767047 | RECRUITING | PHASE3

48 participants

A Study of Apremilast in Children With Oral Ulcers Associated With Behçet's Disease or Juvenile Psoriatic Arthritis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-03-23
Completion:: 2036-03-17

Conditions

Behçet's Disease
Juvenile Psoriatic Arthritis

Interventions

DRUG

No Results Yet

NCT05732311 | RECRUITING | NA

60 participants

Intermittent Theta Burst Stimulation for Maintenance Therapy in Depression

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-04-25
Completion:: 2026-01-31

Conditions

Depression

Interventions

DEVICE

No Results Yet

NCT05732298 | ACTIVE_NOT_RECRUITING | NA

72 participants

Theta Burst Stimulation in Pharmacologically Untreated Patients as Sole Antidepressant Treatment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-02-27
Completion:: 2025-12-31

Conditions

Depression

Interventions

DEVICE

No Results Yet

NCT05681351 | ACTIVE_NOT_RECRUITING | PHASE3

885 participants

CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2022-12-13
Completion:: 2027-03-31

Conditions

Severe Hypertriglyceridemia

Interventions

DRUG

No Results Yet

NCT05649800 | RECRUITING

140 participants

Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-03-17
Completion:: 2025-11-26

Conditions

Cognitive Dysfunction
Stroke
Dementia
Depression
Delirium

No Results Yet

NCT05645172 | ACTIVE_NOT_RECRUITING

137 participants

Retention Rate of Acalabrutinib in a Non-interventional Setting

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-01
Start Date:: 2022-12-12
Completion:: 2026-10-15

Conditions

Chronic Lymphocytic Leukaemia (CLL)

No Results Yet

NCT05617508 | COMPLETED | PHASE2

80 participants

N-DOSE AD: A Dose Optimization Trial of Nicotinamide Riboside in Alzheimer's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2022-11-22
Completion:: 2025-06-05

Conditions

Alzheimer Disease
Dementia

Interventions

OTHER
DIETARY_SUPPLEMENT

No Results Yet

NCT05595213 | COMPLETED | NA

27 participants

Wrist Cooling for Hot Flashes Clinical Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-03-05
Completion:: 2025-01-02

Conditions

Hot Flashes

Interventions

DEVICE
OTHER

Results Available

NCT05592652 | COMPLETED | NA

300 participants

Identification of the Clinical Specificities of Complex Posttraumatic Stress Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-01-25
Completion:: 2025-07-18

Conditions

Post Traumatic Stress Disorder

Interventions

OTHER

No Results Yet

NCT05572632 | RECRUITING | NA

387 participants

Rehabilitation in Safety-net Environments (RISE) to Improve Outcomes in Vulnerable Patients With COPD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-01-19
Completion:: 2026-12-31

Conditions

COPD (Chronic Obstructive Pulmonary Disease)

Interventions

BEHAVIORAL

No Results Yet

NCT05568212 | RECRUITING | PHASE2

176 participants

Randomized Trial Comparing Standard of Care Versus Immune- Based Combination in Relapsed Stage III Non-small-cell Lung Cancer (NSCLC) Pretreated With Chemoradiotherapy and Durvalumab

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2022-05-02
Completion:: 2026-05-31

Conditions

Non-small-cell Lung Cancer Patients

Interventions

DRUG

No Results Yet

NCT05554302 | RECRUITING | PHASE2

20 participants

Characterization of 18F-Fluciclovine PET Amino Acid Radiotracer in Resected Brain Metastasis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-01-10
Completion:: 2030-01-31

Conditions

Brain Metastases
Brain Cancer

Interventions

DRUG

No Results Yet

NCT05550636 | COMPLETED | PHASE1

15 participants

A Study in Healthy Men to Test Whether BI 1015550 Influences the Amount of Midazolam in the Blood

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2022-10-11
Completion:: 2022-12-19

Conditions

Healthy

Interventions

DRUG

Results Available

NCT05496556 | ACTIVE_NOT_RECRUITING | NA

190 participants

Influence of Food Preferences on the Occurrence of Undernutrition in Treated Patients for Bronchopulmonary Carcinoma Non-small Cell Stage IV

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-01
Start Date:: 2023-11-01
Completion:: 2026-10-01

Conditions

Non-small Cell Bronchopulmonary Carcinoma at Stage IV and Benefiting From First-line Treatment According to Current French Recommendations

Interventions

OTHER

No Results Yet