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Echocardiography With Bubble Test for Tip Location of Central Venous Catheters

NCT06243445 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 22

Last updated 2025-12-01

No results posted yet for this study

Summary

The goal of this prospective observational study is to test the accuracy of the transthoracic echocardiography with bubble test to verify the location of the tip of the central venous catheter in patients undergoing cardiac surgery procedures. The main questions it aims to answer are:

1. Is there a difference in time elapsed between the injection of a saline solution (echogenic contrast) through a central venous catheter and the visualization of micro bubbles in right atrium ("push to bubbles" time) with transthoracic echocardiography, when the catheter tip is placed in four different positions identified by transesophageal echocardiography?
2. Is there a difference in time for the right atrium to be completely filled by bubbles after saline injection in a central venous catheter with the tip placed in four different positions identified by transesophageal echocardiography?
3. In what percentage of patients the acoustic window is good enough to evaluate "push to bubbles" time?
4. Is there a difference in "push to bubbles" time between different echocardiographic projections?
5. Is the bubbles flow laminar or turbulent in the four different positions?
6. Is there a relation between "push to bubble" time and heart rate, blood pressure, pulmonary artery pressure, central venous pressure and cardiac output measured through a pulmonary artery catheter?

Participants will require simultaneously a central venous catheter and an intraoperative transesophageal echocardiography.

Conditions

  • Cardiac Surgery Patient

Interventions

DIAGNOSTIC_TEST

Transthoracic echocardiography for central venous catheter tip location

Measure of time between injection of echographic contrast in the distal lumen of a central venous catheter, inserted via supra/infra clavicular right veins, and visualization, using transthoracic echocardiography, of micro bubbles in right atrium with the catheter tip positioned under transesophageal ultrasound control in four different positions: right atrium, cavo-atrial junction (CAJ), at 4 centimeters proximal to CAJ, in superior vena cava and at 8 centimeters proximal to CAJ

Sponsors & Collaborators

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    lead OTHER

Principal Investigators

  • Gabriella Arlotta · Fondazione Policlinico Universitario A. Gemelli, IRCCS

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-02-01
Primary Completion
2024-04-01
Completion
2025-11-27

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06243445 on ClinicalTrials.gov