Clinical Trials Updated in 2025

NCT04457310 | COMPLETED | PHASE2

112 participants

A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-03-02
Completion:: 2024-03-22

Conditions

Early Course Schizophrenia Spectrum Disorder

Interventions

DRUG
OTHER

Results Available

NCT04424407 | COMPLETED | NA

51 participants

A Novel Use of a Sleep Intervention to Target the Emotion Regulation Brain Network to Treat Depression and Anxiety

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2021-05-28
Completion:: 2024-03-23

Conditions

Insomnia
Depression

Interventions

BEHAVIORAL

Results Available

NCT04347239 | COMPLETED | PHASE2

484 participants

Evaluate the Efficacy & Safety of Leronlimab in Patients With Severe or Critical COVID-19

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2020-04-16
Completion:: 2021-10-24

Conditions

Coronavirus Disease 2019

Interventions

DRUG

Results Available

NCT04271709 | ACTIVE_NOT_RECRUITING | NA

749 participants

Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2019-09-30
Completion:: 2025-09-29

Conditions

Glaucoma
Vision Impairment and Blindness
Cataract
Diabetic Retinopathy
Eye Diseases

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT04139902 | ACTIVE_NOT_RECRUITING | PHASE2

48 participants

Neoadjuvant PD-1 Inhibitor Dostarlimab (TSR-042) vs. Combination of Tim-3 Inhibitor Cobolimab (TSR-022) and PD-1 Inhibitor Dostarlimab (TSR-042) in Melanoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2020-06-12
Completion:: 2025-09-29

Conditions

Melanoma Stage III
Melanoma Stage IV

Interventions

DRUG

No Results Yet

NCT04056247 | ACTIVE_NOT_RECRUITING

10000 participants

Predicting Responsiveness in Oncology Patients Based on Host Response Evaluation During Anti Cancer Treatments

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-15
Start Date:: 2019-10-01
Completion:: 2029-10-01

Conditions

Stage IV Non-small Cell Lung Cancer
Stage IV Malignant Melanoma
Stage IV Small Cell Lung Cancer
Stage III Unresectable Non-Small Cell Lung Cancer
Stage IIIb-d Malignant Melanoma

Interventions

OTHER

No Results Yet

NCT04046991 | COMPLETED | PHASE2

76 participants

Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2020-08-17
Completion:: 2025-06-30

Conditions

Primary Progressive Aphasia

Interventions

DEVICE
BEHAVIORAL

No Results Yet

NCT04043403 | COMPLETED | NA

12 participants

Bilateral Closed Loop Deep Brain Stimulation for Freezing of Gait Using Neural and Kinematic Feedback

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2019-10-28
Completion:: 2025-08-08

Conditions

Parkinson Disease

Interventions

DEVICE

No Results Yet

NCT04028843 | COMPLETED | NA

351 participants

A Smartphone Intervention for WIC Mothers to Improve Nutrition and Weight Gain During Pregnancy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2019-07-12
Completion:: 2024-05-21

Conditions

Weight Gain During Pregnancy

Interventions

BEHAVIORAL

Results Available

NCT04025229 | COMPLETED | NA

30 participants

High Intensity Interval Training in Endometrial Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2019-09-23
Completion:: 2024-09-08

Conditions

Endometrial Cancer

Interventions

BEHAVIORAL

Results Available

NCT03978624 | ACTIVE_NOT_RECRUITING | PHASE2

20 participants

Window of Opportunity Study of Pembrolizumab Alone and in Combinations in Bladder Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2020-09-23
Completion:: 2024-03-25

Conditions

Bladder Cancer

Interventions

DRUG
PROCEDURE

Results Available

NCT03968224 | COMPLETED | PHASE2/PHASE3

160 participants

Effectiveness of Dapagliflozin for Weight Loss

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2018-08-04
Completion:: 2024-07-31

Conditions

PreDiabetes
Obesity, Morbid
Diabetes Mellitus, Type 2

Interventions

DRUG

Results Available

NCT03946449 | COMPLETED | PHASE2

16 participants

Study of Fazirsiran (TAK-999, ARO-AAT) in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2019-10-31
Completion:: 2022-04-28

Conditions

Alpha 1-Antitrypsin Deficiency

Interventions

DRUG

Results Available

NCT03915769 | COMPLETED | PHASE3

198 participants

To Evaluate Efficacy and Long-term Safety of Ozanimod in Japanese Subjects With Moderately to Severely Active Ulcerative Colitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2019-06-03
Completion:: 2025-09-30

Conditions

Colitis, Ulcerative

Interventions

DRUG
OTHER

No Results Yet

NCT03874988 | COMPLETED | NA

110 participants

Building an Evidence Base for Weight Loss Strategies Among Those With Chronic SCI-The GLB-SCI+

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2019-06-01
Completion:: 2021-10-19

Conditions

Spinal Cord Injuries
Obesity
Weight Loss
Diet Modification

Interventions

BEHAVIORAL

No Results Yet

NCT03836105 | COMPLETED

287 participants

CemiplimAb Survivorship Epidemiology

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-15
Start Date:: 2019-06-27
Completion:: 2025-09-29

Conditions

Cutaneous Squamous Cell Carcinoma
Basal Cell Carcinoma

Interventions

DRUG

No Results Yet

NCT03817021 | COMPLETED | NA

1461 participants

ONE PATH: Optimizing Nutrition Education for Parents and Teachers for Healthy Growth

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2022-07-21
Completion:: 2025-07-07

Conditions

Childhood Obesity
Self-regulation
Appetite Regulation

Interventions

BEHAVIORAL

No Results Yet

NCT03749317 | COMPLETED | PHASE2

135 participants

Trial to Evaluate the Efficacy and Safety of IVIEW-1201 in Acute Viral Conjunctivitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2023-02-20
Completion:: 2024-04-30

Conditions

Adenoviral Conjunctivitis

Interventions

DRUG

No Results Yet

NCT03633721 | COMPLETED | PHASE2

25 participants

Acute Effects of Cannabis on Cognition and Mobility in Older HIV-infected and HIV-Un-infected Women

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2020-10-23
Completion:: 2022-05-31

Conditions

HIV
AIDS
Aging

Interventions

DRUG
OTHER

Results Available

NCT03580499 | COMPLETED | NA

43 participants

Vitamin B6 in Reducing Hot Flashes in Participants With Prostate Cancer Undergoing Antiandrogen Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2018-09-13
Completion:: 2024-06-30

Conditions

Hot Flashes
Prostate Carcinoma

Interventions

DIETARY_SUPPLEMENT
OTHER

No Results Yet

NCT03517579 | RECRUITING | NA

10 participants

Personalized Treatment in Thyroid Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2018-12-11
Completion:: 2027-10-15

Conditions

Thyroid Cancer
Graves Disease

Interventions

DEVICE

No Results Yet

NCT03481530 | COMPLETED

41 participants

Role of CGMS Usage in Predicting Risk for Hypoglycemia

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-15
Start Date:: 2018-10-01
Completion:: 2020-01-13

Conditions

Type 2 Diabetes Mellitus
Hypoglycemia

Interventions

DEVICE

No Results Yet

NCT03456128 | COMPLETED | NA

268 participants

Reducing Disability Following Hospital Discharge in Vulnerable Older Adults: The CAPABLE Intervention

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2018-08-25
Completion:: 2023-09-11

Conditions

Disability Physical

Interventions

OTHER

No Results Yet

NCT03392064 | SUSPENDED | PHASE1

6 participants

A Phase 1 Study Evaluating the Safety, Tolerability and Efficacy of AMG 119 in Subjects With RR SCLC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2018-09-10
Completion:: 2028-01-14

Conditions

Small Cell Lung Cancer

Interventions

BIOLOGICAL

No Results Yet

NCT03160274 | RECRUITING

2000 participants

Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-15
Start Date:: 2005-10-19
Completion:: 2030-12-31

Conditions

Pheochromocytoma
Paraganglioma
Inherited Cancer Syndrome
Associated Conditions
Kidney Neoplasms
Bone Cancer
Thyroid Neoplasms
Other Cancer

Interventions

GENETIC

No Results Yet

NCT03143374 | RECRUITING | PHASE2/PHASE3

300 participants

PET Tau - Neurodegenerative Disease Imaging

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2016-08-23
Completion:: 2030-09-30

Conditions

Neurodegenerative Disease

Interventions

DRUG

No Results Yet

NCT03124329 | WITHDRAWN | NA

0 participants

Efficacy of Methods to Treat Multiple Gingival Recession Defects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2017-05-01
Completion:: 2019-06-19

Conditions

Gingival Recession

Interventions

PROCEDURE
BIOLOGICAL
DEVICE

No Results Yet

NCT03118466 | COMPLETED | PHASE2

41 participants

Mitoxantrone, Etoposide, and Cytarabine (MEC) Plus Lenalidomide for Relapsed or Refractory Acute Myeloid Leukemia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2017-09-25
Completion:: 2019-08-29

Conditions

AML

Interventions

DRUG

Results Available

NCT03076255 | COMPLETED | NA

12 participants

Using a Head and Neck Maskless Immobilization Device For Patients With Intracranial Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2017-02-24
Completion:: 2020-11-03

Conditions

Brain and Nervous System
Intracranial Neoplasm
Head and Neck Cancer

Interventions

PROCEDURE
DEVICE

Results Available

NCT03069937 | COMPLETED | PHASE2

52 participants

Phase II Study of Docetaxel Before Degarelix in Patients With Newly Diagnosed Metastatic Prostate Cancer.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2017-03-01
Completion:: 2021-03-03

Conditions

Metastatic Prostatic Adenocarcinoma

Interventions

DRUG

Results Available

NCT03068273 | COMPLETED | NA

157 participants

Managing Type 1 and High Risk Type 2 Diabetes in the Hospital Setting: Glucose as a Vital Sign

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2015-05-31
Completion:: 2020-03-17

Conditions

Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2

Interventions

DEVICE

Results Available

NCT03006978 | COMPLETED | NA

24 participants

A Pilot Study of the TearCare System in Adults With Dry Eye Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2017-01-31
Completion:: 2017-02-28

Conditions

Dry Eye

Interventions

DEVICE

Results Available

NCT02831335 | RECRUITING

120 participants

Technical Development of Multi-Parametric Renocerebral MRI

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-15
Start Date:: 2026-12-01
Completion:: 2030-12-31

Conditions

Aging

Interventions

OTHER

No Results Yet

NCT02819362 | COMPLETED

70 participants

Benefit of a Diagnostic MRI in Case of Pathological Nipple Discharge With Normal Mammography / Ultrasound

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-15
Start Date:: 2014-04-30
Completion:: 2016-12-31

Conditions

Breast Cancer

Interventions

DEVICE

Results Available

NCT02710123 | COMPLETED | NA

113 participants

Sub-Threshold Exercise Treatment for Adolescents With Sports Related Concussion

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2015-09-30
Completion:: 2018-05-31

Conditions

Brain Injury
Concussion

Interventions

OTHER

Results Available

NCT02512926 | COMPLETED | PHASE1

4 participants

Carfilzomib in Combination With Cyclophosphamide and Etoposide for Children

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2016-02-16
Completion:: 2021-08-28

Conditions

Relapsed Solid Tumors
Refractory Solid Tumors
Relapsed Leukemia
Refractory Leukemia

Interventions

DRUG

No Results Yet

NCT02457832 | COMPLETED | NA

87 participants

Motor Training in PD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2015-06-01
Completion:: 2022-12-31

Conditions

Parkinson Disease

Interventions

BEHAVIORAL

Results Available

NCT02446132 | TERMINATED | PHASE3

1197 participants

Long Term, Extension Study of the Safety and Efficacy of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2015-11-13
Completion:: 2024-09-06

Conditions

Agitation in Patients With Dementia of the Alzheimer's Type

Interventions

DRUG

Results Available

NCT02412228 | COMPLETED | PHASE2

12 participants

Ixazomib, Cyclophosphamide and Dexamethasone for Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2015-08-31
Completion:: 2019-03-29

Conditions

Multiple Myeloma

Interventions

DRUG

Results Available

NCT02315157 | WITHDRAWN | PHASE1

0 participants

Bendamustine Hydrochloride in Treating Patients With Previously Treated Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-15
Start Date:: 2014-06-30
Completion:: 2018-11-30

Conditions

Multiple Myeloma
Plasma Cell Leukemia

Interventions

DRUG

No Results Yet