Clinical Trials Updated in 2025

NCT06976515 | RECRUITING

90 participants

Study for Remote Investigation of Evaporative Dry Eye Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-09
Start Date:: 2025-09-01
Completion:: 2027-07-01

Conditions

Evaporative Loss Dry Eye Disease

No Results Yet

NCT06890611 | COMPLETED | PHASE1

125 participants

A Study of Bimagrumab Alone (LY3985863) and Bimagrumab With Tirzepatide (LY900042) in Healthy Participants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2025-03-25
Completion:: 2025-09-26

Conditions

Healthy

Interventions

DRUG

No Results Yet

NCT06729606 | COMPLETED | PHASE3

471 participants

Aviptadil for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2021-04-20
Completion:: 2022-08-22

Conditions

Covid19

Interventions

BIOLOGICAL
DRUG

Results Available

NCT06729593 | COMPLETED | PHASE3

87 participants

Remdesivir for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2021-04-20
Completion:: 2022-08-22

Conditions

Covid19

Interventions

BIOLOGICAL
DRUG

Results Available

NCT06647524 | RECRUITING | PHASE2

10 participants

Pilot fMRI Studies of Aging-Related Effects of THC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2025-07-01
Completion:: 2027-12-31

Conditions

THC

Interventions

DRUG

No Results Yet

NCT06609135 | COMPLETED | NA

20 participants

Relationship Between EIT and Respiratory Status in Very Preterm Infants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2023-11-04
Completion:: 2024-08-31

Conditions

Chronic Lung Disease of Prematurity
Bronchopulmonary Dysplasia
Premature Lungs

Interventions

DEVICE

Results Available

NCT06566170 | RECRUITING

6250 participants

A Real-World Comparative Study of Donanemab (LY3002813) Plus Usual Care Versus Usual Care Alone in US Participants With Early Symptomatic Alzheimer's Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-09
Start Date:: 2024-10-07
Completion:: 2033-02-28

Conditions

Alzheimer Disease

Interventions

DRUG

No Results Yet

NCT06553001 | WITHHELD

[Trial of device that is not approved or cleared by the U.S. FDA]

Last Updated:: 2025-10-09

No Results Yet

NCT06552988 | WITHHELD

[Trial of device that is not approved or cleared by the U.S. FDA]

Last Updated:: 2025-10-09

No Results Yet

NCT06507930 | RECRUITING | NA

200 participants

The COMPASSION Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2024-09-01
Completion:: 2026-10-01

Conditions

Breast Cancer
Metastatic Breast Cancer
Advanced Breast Cancer
Unresectable Breast Carcinoma

Interventions

OTHER

No Results Yet

NCT06488053 | WITHHELD

[Trial of device that is not approved or cleared by the U.S. FDA]

Last Updated:: 2025-10-09

No Results Yet

NCT06488040 | WITHHELD

[Trial of device that is not approved or cleared by the U.S. FDA]

Last Updated:: 2025-10-09

No Results Yet

NCT06469242 | COMPLETED | NA

106 participants

Clinical Performance of Two Frequent Replacement Silicone Hydrogel Multifocal Contact Lenses

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2024-07-18
Completion:: 2024-10-08

Conditions

Presbyopia

Interventions

DEVICE

Results Available

NCT06451939 | WITHHELD

[Trial of device that is not approved or cleared by the U.S. FDA]

Last Updated:: 2025-10-09

No Results Yet

NCT06434571 | RECRUITING | PHASE2

90 participants

Comparing Telehealth-Delivered CBT-I to Web-Based CBT-I to Enhance Sleep, Reduce Fatigue, and Promote Neuroprotection

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2024-10-11
Completion:: 2028-07-31

Conditions

Multiple Sclerosis
Insomnia

Interventions

BEHAVIORAL

No Results Yet

NCT06373367 | ACTIVE_NOT_RECRUITING | NA

36 participants

Preeclampsia Educational Program Study (PrEPS)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2024-10-01
Completion:: 2025-05-29

Conditions

Preeclampsia
Preeclampsia Severe
Preeclampsia Mild
Preeclampsia Postpartum

Interventions

OTHER

No Results Yet

NCT06369571 | ENROLLING_BY_INVITATION | PHASE1/PHASE2

22 participants

Improving Cardiovascular Health Risks in Adults With Epilepsy on a Modified Atkins Diet

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2024-10-04
Completion:: 2027-01-31

Conditions

Epilepsy
Dyslipidemia

Interventions

DRUG
OTHER

No Results Yet

NCT06338462 | COMPLETED | NA

269 participants

Cali Sin Tos Aim 2

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2024-03-28
Completion:: 2024-09-11

Conditions

Tuberculosis

Interventions

DEVICE
DIAGNOSTIC_TEST

Results Available

NCT06336603 | COMPLETED | PHASE4

20 participants

A Study Assessing the Efficacy of Combined Use of Clascoterone 1% Cream and Adapalene 0.3% for the Treatment of Acne

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2023-11-15
Completion:: 2024-10-29

Conditions

Acne Vulgaris

Interventions

DRUG

Results Available

NCT06000449 | COMPLETED | NA

116 participants

Center M: Digital Health Innovation Pilot

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2024-02-15
Completion:: 2025-06-15

Conditions

Perinatal Depression

Interventions

BEHAVIORAL

No Results Yet

NCT05959629 | TERMINATED | NA

56 participants

Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2023-10-11
Completion:: 2024-05-02

Conditions

Endodontic Disease
Root Canal Infection

Interventions

DEVICE
OTHER

Results Available

NCT05945602 | RECRUITING

80 participants

Neurophysiologic Biomarkers for Cognitive Rehabilitation

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-09
Start Date:: 2023-10-01
Completion:: 2028-09-30

Conditions

Schizophrenia Spectrum Disorders

Interventions

OTHER

No Results Yet

NCT05940272 | RECRUITING | NA

48 participants

Study of a Communication Training Intervention for Large B-Cell Lymphoma Providers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2023-07-03
Completion:: 2028-07-03

Conditions

Lymphoma, B-Cell
Lymphoma
Large-cell Lymphoma
Large B-cell Lymphoma
DLBCL - Diffuse Large B Cell Lymphoma
Mediastinal B-Cell Diffuse Large Cell Lymphoma

Interventions

BEHAVIORAL

No Results Yet

NCT05922995 | TERMINATED | EARLY_PHASE1

20 participants

The Effects of Tasimelteon in Participants With REM Behavior Disorder (RBD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2023-09-30
Completion:: 2023-12-01

Conditions

REM Behavior Disorder

Interventions

DRUG

No Results Yet

NCT05852145 | RECRUITING | PHASE1/PHASE2

52 participants

Oral Changes With Caloric and no Caloric Sweeteners

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2025-08-01
Completion:: 2025-12-31

Conditions

pH
Microbiome
Dental Plaque

Interventions

DRUG
OTHER

No Results Yet

NCT05754333 | COMPLETED | PHASE3

107 participants

A Study to Find Out if ASP5354 Can Clearly Help Show the Ureter During Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2023-08-02
Completion:: 2024-12-17

Conditions

Intraoperative Ureter Visualization
Abdominolpelvic Surgery

Interventions

DRUG

Results Available

NCT05691023 | ACTIVE_NOT_RECRUITING

50 participants

VNS-REHAB At-Home - Post-Market Study for Using the Vivistim System® at Home

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-09
Start Date:: 2023-06-01
Completion:: 2026-12-31

Conditions

Ischemic Stroke
Upper Extremity Problem

Interventions

DEVICE

No Results Yet

NCT05669833 | RECRUITING | PHASE3

63 participants

Guselkumab vs Golimumab in PsA TNF Inadequate Responder Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2023-07-14
Completion:: 2026-10-31

Conditions

Psoriatic Arthritis

Interventions

DRUG

No Results Yet

NCT05599945 | COMPLETED | PHASE1

48 participants

First Human Dose Trial for a New Medication to Potentially Treat Liver Diseases

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2022-11-23
Completion:: 2025-08-29

Conditions

Healthy Volunteers
Hepatic Steatosis

Interventions

DRUG

No Results Yet

NCT05559099 | COMPLETED | PHASE2

597 participants

Tecovirimat for Treatment of Monkeypox Virus

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2022-10-10
Completion:: 2024-09-03

Conditions

Monkeypox

Interventions

DRUG

Results Available

NCT05540782 | ACTIVE_NOT_RECRUITING

200 participants

A Study of Cognitive Health in Survivors of Prostate Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-09
Start Date:: 2022-09-08
Completion:: 2026-09-08

Conditions

Prostate Cancer
Survivorship

Interventions

BEHAVIORAL

No Results Yet

NCT05514444 | COMPLETED | PHASE1

64 participants

Study of MK-4464 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced/Metastatic Solid Tumors (MK-4464-001)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2022-09-25
Completion:: 2025-09-18

Conditions

Advanced/Metastatic Solid Tumors
Neoplasms

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT05496374 | COMPLETED | PHASE2

25 participants

A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of SPR720 as Compared With Placebo for the Treatment of Participants With Mycobacterium Avium Complex (MAC) Pulmonary Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2022-12-14
Completion:: 2024-10-08

Conditions

Nontuberculous Mycobacterial Pulmonary Disease (NTM-PD)

Interventions

DRUG

No Results Yet

NCT05491538 | RECRUITING | NA

20 participants

Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2022-12-01
Completion:: 2026-11-27

Conditions

Schizophrenia
Bipolar Disorder
Depressive Disorder, Major
Stress Disorder, Post-Traumatic

Interventions

BEHAVIORAL

No Results Yet

NCT05444049 | COMPLETED | NA

6 participants

NEURESCUE Device as an Adjunct to In-Hospital Cardiac Arrest (ARISE)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2022-12-08
Completion:: 2024-09-30

Conditions

Cardiac Arrest
Cardiopulmonary Arrest
Cardiovascular Diseases

Interventions

DEVICE

No Results Yet

NCT05437510 | COMPLETED | PHASE3

8057 participants

Study of a Single Intramuscular Dose of Nirsevimab in the Prevention of Hospitalizations Due to Respiratory Syncytial Virus (RSV) Infection in Healthy Term and Preterm Infants During the First Year of Life

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2022-08-08
Completion:: 2024-03-27

Conditions

RSV Immunization
Healthy Volunteer

Interventions

BIOLOGICAL

Results Available

NCT05385497 | COMPLETED | NA

10 participants

Combining Aerobic Exercise and Virtual Reality for Cognitive-motor Rehabilitation in PD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2022-11-07
Completion:: 2023-07-15

Conditions

Parkinson's Disease

Interventions

OTHER
DEVICE

No Results Yet

NCT05370521 | TERMINATED | PHASE2

27 participants

A Study of Safety and Efficacy of Tildacerfont in Females With Polycystic Ovary Syndrome and Elevated Adrenal Androgens

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2022-05-15
Completion:: 2023-08-03

Conditions

Polycystic Ovary Syndrome

Interventions

DRUG

Results Available

NCT05321368 | RECRUITING | NA

425 participants

A Cardiometabolic Health Program Linked With Clinical-Community Support and Mobile Health Telemonitoring to Reduce Health Disparities

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-09
Start Date:: 2023-10-16
Completion:: 2026-10-21

Conditions

Hypertension
High Blood Pressure
Diabetes
Chronic Kidney Diseases

Interventions

BEHAVIORAL

No Results Yet

NCT05306210 | COMPLETED

1029 participants

Forxiga CKD Japan Post-Marketing Surveillance (PMS)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-09
Start Date:: 2022-04-12
Completion:: 2024-10-08

Conditions

Chronic Kidney Disease

No Results Yet