Clinical Trials Updated in 2025

NCT04361708 | RECRUITING | PHASE1

54 participants

Safety of Combining Irinotecan With 5-FU, Leucovorin/Folinic Acid, Oxaliplatin, and Docetaxel Chemotherapies

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2020-05-08
Completion:: 2026-06-30

Conditions

Pancreatic Adenocarcinoma
Gastroesophageal Junction Adenocarcinoma
Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT04340531 | ACTIVE_NOT_RECRUITING | NA

810 participants

Effectiveness of a Multi-Level Smoking Cessation Program for High-Risk Women in Rural Communities

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2021-01-30
Completion:: 2025-03-13

Conditions

Tobacco-Related Carcinoma

Interventions

OTHER

No Results Yet

NCT04300335 | SUSPENDED | NA

45 participants

The Feasibility and Effects of Exercise on Patients Suffering From Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2026-03-31
Completion:: 2026-10-31

Conditions

Multiple Myeloma

Interventions

OTHER

No Results Yet

NCT04295863 | RECRUITING | PHASE1

264 participants

Comparing Dosing Intervals of Nivolumab or Pembrolizumab in Locally Advanced or Metastatic Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2020-06-25
Completion:: 2026-04-12

Conditions

Metastatic Cancer

Interventions

DRUG

No Results Yet

NCT04294043 | RECRUITING | PHASE1

40 participants

IV Gallium Study for Patients With Cystic Fibrosis Who Have NTM (ABATE Study)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2021-06-17
Completion:: 2027-03-31

Conditions

Nontuberculous Mycobacterium Infection

Interventions

DRUG

No Results Yet

NCT04280497 | RECRUITING | NA

1800 participants

Rapid Recognition of Corticosteroid Resistant or Sensitive Sepsis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2020-04-10
Completion:: 2025-12-31

Conditions

Sepsis

Interventions

DRUG

No Results Yet

NCT04261673 | ACTIVE_NOT_RECRUITING | NA

120 participants

Prospective Randomized Evaluation of Decompressive Ipsilateral Craniectomy for Traumatic Acute Epidural Hematoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2020-05-23
Completion:: 2025-09-14

Conditions

Epidural Hematoma
Brain Herniation
Decompressive Craniectomy
Craniotomy

Interventions

PROCEDURE

No Results Yet

NCT04260126 | COMPLETED | PHASE2

95 participants

Study of PDS0101 and Pembrolizumab Combination I/O in Subjects With HPV16 + Recurrent and/or Metastatic HNSCC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2021-03-29
Completion:: 2025-05-14

Conditions

Metastatic Head and Neck Cancer
Recurrent Head and Neck Cancer
HPV Positive Oropharyngeal Squamous Cell Carcinoma
Neoplasms, Head and Neck

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT04234997 | COMPLETED | PHASE2

14 participants

Suvorexant to Reduce Symptoms of Nicotine Use

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2021-08-23
Completion:: 2024-08-22

Conditions

Smoking Cessation

Interventions

DRUG

Results Available

NCT04229979 | ACTIVE_NOT_RECRUITING | PHASE3

127 participants

Galinpepimut-S Versus Investigator's Choice of Best Available Therapy for Maintenance in AML CR2/CRp2

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2021-02-08
Completion:: 2025-12-31

Conditions

Acute Myeloid Leukemia

Interventions

BIOLOGICAL
DRUG
OTHER

No Results Yet

NCT04209504 | RECRUITING

60 participants

Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-01
Start Date:: 2021-10-12
Completion:: 2026-08-31

Conditions

Shoulder Surgery
Shoulder Pain
Shoulder Injuries
Shoulder Arthritis
Shoulder Disease
Rotator Cuff Tears
Rotator Cuff Injuries
Rotator Cuff Arthropathy of Left Shoulder
Rotator Cuff Arthropathy of Right Shoulder
Rotator Cuff Repair

Interventions

DIAGNOSTIC_TEST
DRUG
DEVICE

No Results Yet

NCT04198987 | COMPLETED

20 participants

Dietary Monosaccharide Supplementation in Patients With Congenital Disorders of Glycosylation

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-01
Start Date:: 2018-12-06
Completion:: 2025-06-11

Conditions

Congenital Disorder of Glycosylation

No Results Yet

NCT04174924 | COMPLETED

126 participants

Molecular Background of Endothelial Cell Loss in Patients With Phakic Intraocular Lenses: a Tear and Aqueous Humour Analysis Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-01
Start Date:: 2020-07-02
Completion:: 2025-02-01

Conditions

Cataract
Phakic Intraocular Lens Explantation

Interventions

PROCEDURE

No Results Yet

NCT04132362 | RECRUITING

1080 participants

Benefits of Personalised Music in Dementia - a Feasibility Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-01
Start Date:: 2019-11-28
Completion:: 2026-04-30

Conditions

Dementia

Interventions

BEHAVIORAL

No Results Yet

NCT04123457 | ENROLLING_BY_INVITATION

100 participants

Biorepository of Biomarkers for Optimization of Microvascular Treatment of Lymphedema

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-01
Start Date:: 2019-08-01
Completion:: 2026-08-31

Conditions

Lymphedema

No Results Yet

NCT04109053 | WITHDRAWN

0 participants

Ultrasensitive Electroanatomic Mapping to Adjudicate Endpoints for Ablation In Paroxysmal AF Patients Using Cryoballoon

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-01
Start Date:: 2020-03-02
Completion:: 2021-03-31

Conditions

Paroxysmal Atrial Fibrillation

No Results Yet

NCT04108858 | TERMINATED | PHASE1/PHASE2

2 participants

Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Maintenance Treatment (Trastuzumab and Pertuzumab) After Initial Chemotherapy in a Phase Ib/II Trial for Advanced HER2 Positive Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2021-05-20
Completion:: 2022-04-29

Conditions

Anatomic Stage IV Breast Cancer AJCC v8
HER2-Positive Breast Carcinoma
Metastatic Breast Carcinoma

Interventions

DRUG
BIOLOGICAL

Results Available

NCT04075084 | RECRUITING

1400 participants

Observation of Clinical Routine Care for Patients With BIOTRONIK Implantable Cardiac Monitors (ICMs)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-01
Start Date:: 2019-10-28
Completion:: 2027-05-30

Conditions

Tachycardia
Atrial Fibrillation
Syncope
Bradycardia
Cryptogenic Stroke

No Results Yet

NCT04041778 | COMPLETED

17 participants

'Understanding the Electrophysiological Substrate Underlying Persistent Atrial Fibrillation Study II (USURP AF- Study II)'

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-01
Start Date:: 2019-07-25
Completion:: 2024-09-30

Conditions

Atrial Fibrillation Mechanisms
Persistent Atrial Fibrillation
Substrate Ablation
Pulmonary Vein Isolation
Non-contact Mapping

Interventions

OTHER

No Results Yet

NCT04007276 | NOT_YET_RECRUITING | PHASE4

60 participants

The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2026-11-10
Completion:: 2031-06-01

Conditions

Glaucoma
Glaucoma, Open-Angle
Glaucoma; Drugs
Droopy Eyelid
Ptosis
Glaucoma, Primary Open Angle

Interventions

DRUG
OTHER

No Results Yet

NCT04001777 | ACTIVE_NOT_RECRUITING | PHASE1

80 participants

A Study of APG-1252 Plus Osimertinib(AZD9291) in EGFR TKI Resistant NSCLC Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2019-07-04
Completion:: 2025-12-31

Conditions

EGFR Positive Non-small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT04000152 | TERMINATED | NA

296 participants

RCT Study to Validate niPGT-A Clinical Benefit.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2020-06-29
Completion:: 2025-04-18

Conditions

Aneuploidy
Chromosome Abnormality
Infertility

Interventions

DIAGNOSTIC_TEST
OTHER

No Results Yet

NCT03993873 | ACTIVE_NOT_RECRUITING | PHASE1

95 participants

Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2019-09-05
Completion:: 2024-01-08

Conditions

Advanced Solid Tumor
Metastatic Solid Tumors
MET Gene Alterations

Interventions

DRUG

No Results Yet

NCT03985345 | COMPLETED | NA

55 participants

Prospective Evaluation of the Connected EMY Biofeedback Probe in the Management of Stress Urinary Incontinence.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2019-09-02
Completion:: 2020-09-09

Conditions

Stress Urinary Incontinence

Interventions

DEVICE

No Results Yet

NCT03946215 | COMPLETED | NA

8 participants

Cardiorespiratory Responses to Treadmill Running at Different Slopes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2018-09-01
Completion:: 2018-12-17

Conditions

Cardiorespiratory Responses
Well-trained Athletes

Interventions

OTHER

No Results Yet

NCT03925025 | COMPLETED | PHASE3

1728 participants

Effectiveness of Calcium Channel Blockade for OP and Carbamate Pesticide Poisoning

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2020-06-11
Completion:: 2025-03-31

Conditions

Anticholinesterase Insecticide Poisoning
Pesticide Poisoning

Interventions

DRUG

No Results Yet

NCT03857919 | COMPLETED | NA

235 participants

TearCare System to Treat Dry Eye Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2019-03-03
Completion:: 2020-02-17

Conditions

Dry Eye
Meibomian Gland Dysfunction

Interventions

DEVICE

Results Available

NCT03761173 | COMPLETED

1200 participants

FlowTriever All-Comer Registry for Patient Safety and Hemodynamics

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-01
Start Date:: 2018-12-15
Completion:: 2024-09-04

Conditions

PE - Pulmonary Embolism
PE - Pulmonary Thromboembolism

Interventions

DEVICE
DRUG

Results Available

NCT03744156 | COMPLETED | NA

131 participants

Sleep and Pain Interventions in Women With Fibromyalgia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2019-02-07
Completion:: 2025-05-31

Conditions

Fibromyalgia
Insomnia
Chronic Widespread Pain

Interventions

BEHAVIORAL

No Results Yet

NCT03688503 | COMPLETED | NA

59 participants

Magnesium Supplementation and Blood Pressure Reduction

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2019-02-15
Completion:: 2020-01-09

Conditions

Blood Pressure

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT03687723 | COMPLETED

93 participants

Observational Study of the Clinical Use of the OCS™ Heart

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-01
Start Date:: 2016-10-31
Completion:: 2024-12-31

Conditions

Heart Transplantation

Interventions

DEVICE

No Results Yet

NCT03563248 | ACTIVE_NOT_RECRUITING | PHASE2

168 participants

Losartan and Nivolumab in Combination With FOLFIRINOX and SBRT in Localized Pancreatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2018-08-10
Completion:: 2022-02-16

Conditions

Pancreatic Cancer

Interventions

DRUG
RADIATION
PROCEDURE

No Results Yet

NCT03526848 | COMPLETED | PHASE1

26 participants

3BNC117 and 10-1074 in ART-treated Individuals

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2018-06-05
Completion:: 2021-09-30

Conditions

Human Immunodeficiency Virus

Interventions

DRUG
OTHER

No Results Yet

NCT03513185 | COMPLETED

1863 participants

Assessment of SSD in Outpatients Using SSS-CN

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-01
Start Date:: 2017-09-01
Completion:: 2021-12-30

Conditions

Somatization Disorder

Interventions

DRUG

No Results Yet

NCT03503097 | TERMINATED

799 participants

Genetic Testing for Men With Metastatic Prostate Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-01
Start Date:: 2017-08-21
Completion:: 2024-08-21

Conditions

Metastatic Prostate Carcinoma
Stage IV Prostate Cancer AJCC v8
Stage IVB Prostate Cancer AJCC v8

Interventions

PROCEDURE
OTHER
BEHAVIORAL

No Results Yet

NCT03417921 | SUSPENDED | PHASE1/PHASE2

60 participants

A Study of ABTL0812 in Pancreatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2021-04-26
Completion:: 2023-04-26

Conditions

Pancreatic Cancer

Interventions

DRUG

No Results Yet

NCT03410667 | ACTIVE_NOT_RECRUITING | NA

67 participants

Incontinence and Quality of Life in Children With Spina Bifida

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2019-12-01
Completion:: 2026-03-15

Conditions

Spina Bifida
Myelomeningocele

Interventions

BEHAVIORAL

No Results Yet

NCT03396276 | ENROLLING_BY_INVITATION | PHASE4

3000 participants

Houston Emergency Opioid Engagement System

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2018-04-01
Completion:: 2030-08-31

Conditions

Opioid Use Disorder

Interventions

DRUG
BEHAVIORAL

No Results Yet

NCT03158454 | ACTIVE_NOT_RECRUITING | NA

200 participants

Capsula Closure vs. Non-Capsula Closure: Hip Arthroscopy in Danish Patients With Femoroacetabular Impingement (FAI)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-01
Start Date:: 2017-06-15
Completion:: 2022-12-01

Conditions

Hip Injuries

Interventions

PROCEDURE

No Results Yet

NCT03074487 | COMPLETED

50 participants

Evaluating Monitoring Techniques for Postoperative Spinal Cord Ischemia

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-01
Start Date:: 2017-01-31
Completion:: 2025-03-31

Conditions

Monitoring
Postoperative
Spinal Cord Ischemia
Thoracoabdominal Aneurysm
TAAA
NIRS
Long Loop Reflexes
F-waves

Interventions

DEVICE

No Results Yet