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Effectiveness of Calcium Channel Blockade for OP and Carbamate Pesticide Poisoning

NCT03925025 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 1728

Last updated 2025-10-01

No results posted yet for this study

Summary

This study evaluates whether the addition of intravenous magnesium sulphate or nimodipine to standard therapy (supportive care plus for all patients atropine and, for OP insecticide poisoned patients, pralidoxime) benefits patients after acute anticholinesterase self-poisoning with OP or carbamate insecticides.

Conditions

  • Anticholinesterase Insecticide Poisoning
  • Pesticide Poisoning

Interventions

DRUG

Magnesium Sulfate

Treatment in addition to standard therapy

DRUG

Nimodipine

Treatment in addition to standard therapy

Sponsors & Collaborators

  • Toxicology Society of Bangladesh

    collaborator OTHER

  • University of Edinburgh

    lead OTHER

Principal Investigators

  • Dr Fazle Rabbi Chowdhury, MD · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-06-11
Primary Completion
2025-03-31
Completion
2025-04-30

Countries

  • Bangladesh

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03925025 on ClinicalTrials.gov