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Respiratory Quotient and Phosphate Changes During Early Critical Illness

NCT07800143 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2026-09-02

No results posted yet for this study

Summary

Critically ill patients often experience major changes in metabolism during the first days of intensive care. When nutrition is started or increased after a period of reduced intake, some patients may develop refeeding syndrome, a potentially serious condition associated with shifts in electrolytes such as phosphate, potassium, and magnesium.

This study will investigate whether changes in respiratory quotient (RQ), measured by indirect calorimetry, are associated with changes in serum phosphate during the first intensive care week. RQ reflects the balance between oxygen consumption and carbon dioxide production and provides information about which energy substrates are being used by the body. A rising RQ may indicate increasing carbohydrate metabolism and could potentially provide an early physiological marker of metabolic changes associated with refeeding.

Mechanically ventilated adult intensive care patients will undergo daily indirect calorimetry during the first five days of the study period, with an additional measurement on day 7 when feasible. Serum phosphate and other electrolytes, nutritional intake, insulin treatment, ventilator parameters, and relevant physiological variables will be recorded at corresponding time points.

The study will also evaluate how well established screening criteria for refeeding risk, including the NICE criteria, identify patients who subsequently develop metabolic changes consistent with refeeding. No study-specific changes to nutrition or other treatment will be made.

This accurately reflects the observational nature of the study: routine IC, laboratory and nutritional data are collected without changing treatment.

Conditions

  • Refeeding Syndrome
  • Critical Illness
  • Metabolic Changes During Critical Illness

Interventions

OTHER

Nutritional Exposure During Early Critical Illness

Enteral and/or parenteral nutrition is provided according to usual clinical care. Energy intake, carbohydrate intake, protein intake, fat intake, and changes in nutritional delivery are recorded prospectively to evaluate their relationship with respiratory quotient, serum phosphate, and other metabolic variables. No nutrition strategy is assigned by the study.

Sponsors & Collaborators

  • Vastra Gotaland Region

    lead OTHER_GOV

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-11-01
Primary Completion
2028-12-01
Completion
2028-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07800143 on ClinicalTrials.gov