Dynamic Trajectories of Pupillary Light Reflex Parameters and Prognosis in Critically Ill Patients: A Multicenter Prospective Cohort Study

Summary

This multicenter prospective observational cohort study aims to investigate the association between early dynamic trajectories of pupillary light reflex parameters and clinical outcomes in critically ill patients admitted to emergency intensive care units. Quantitative pupillometry will be performed during the first 7 days after EICU admission. Constriction velocity will be the primary parameter for trajectory analysis, while dilation velocity, pupil diameter, constriction percentage, maximum constriction velocity, and latency will be analyzed as supplementary parameters. The study will evaluate whether these dynamic pupillary trajectories are associated with discharge outcome and 90-day functional outcome assessed by the Glasgow Outcome Scale-Extended.

Conditions

• Critical Illness
• Pupillometry
• Prognosis

Sponsors & Collaborators

• Zhejiang Provincial People's Hospital

  collaborator OTHER

• Zhejiang Provincial Tongde Hospital

  collaborator OTHER

• Jinhua Municipal Central Hospital

  collaborator OTHER

• Huzhou Central Hospital

  collaborator OTHER

• Lishui Country People's Hospital

  collaborator OTHER

• Lishui Municipal Central Hospital

  collaborator OTHER_GOV

• Ningbo Medical Center Lihuili Hospital

  collaborator OTHER_GOV

• The Second Affiliated Hospital of Jiaxing University

  collaborator OTHER

• The Fourth Affiliated Hospital of Zhejiang University School of Medicine

  collaborator OTHER

• The Third Affiliated Hospital of Wenzhou Medical University

  collaborator OTHER

• Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University

  collaborator OTHER

• People's Hospital of Quzhou

  collaborator OTHER

• First People's Hospital of Hangzhou

  collaborator OTHER

• Second Affiliated Hospital, School of Medicine, Zhejiang University

  lead OTHER

Principal Investigators

• Mao Zhang, MD · Second Affiliated Hospital, School of Medicine, Zhejiang University

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-06-06

Primary Completion

2026-10-13

Completion

2026-10-13