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Scaffolding in AI-Empowered Cognitive Training Improves Outcomes in Cognitive Impairment

NCT07788209 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 516

Last updated 2026-08-26

No results posted yet for this study

Summary

This retrospective study aimed to validate and compare two individualized, closed-loop, AI-driven computerized cognitive training programs with a conventional non-AI training program in a real-world clinical setting. Using objective tablet-recorded data from patients' prior treatment, participants were categorized into three groups according to the training recommendation strategy they actually received. Changes in global cognitive function and specific cognitive domains after 8 weeks of training were compared across groups to evaluate the association between different training strategies and cognitive outcomes.

Conditions

Interventions

BEHAVIORAL

AI-Based Adaptive CCT Optimized for Cognitive Improvement

Participants received a multi-domain computerized cognitive training program delivered on a tablet. The program used an AI-based adaptive, closed-loop recommendation strategy to individualize training tasks and difficulty levels, with the goal of maximizing cognitive improvement over the training period.

BEHAVIORAL

AI-Based Adaptive CCT Optimized for Cognitive Performance

Participants received a multi-domain computerized cognitive training program delivered on a tablet. The program used an AI-based adaptive, closed-loop recommendation strategy to individualize training tasks and difficulty levels, with the goal of maximizing cognitive task performance during training.

BEHAVIORAL

Conventional Non-AI CCT

Participants received a conventional computerized cognitive training program delivered on a tablet. Training tasks were randomly selected within the cognitive domains corresponding to participants' symptomatic impairments and difficulty levels were fixed.

Sponsors & Collaborators

  • Xuanwu Hospital, Beijing

    lead OTHER

Eligibility

Min Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-15
Primary Completion
2027-08-25
Completion
2027-08-25

Countries

  • China

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07788209 on ClinicalTrials.gov