The Feasibility and Effect of Digital Cognitive Training in Mild Cognitive Impairment

Summary

The goal of this study is to assess the feasibility and effect of digital cognitive training based on the principles of Differential Outcome Training (DOT) in patients with Mild Cognitive Impairment. In DOT training, each stimulus-response pair to be learnt is followed by a unique reinforcer, as opposed to non-DOT (NDOT) training, where the stimulus-response pairs are all followed by a random reinforcer. DOT training is believed to boost learning more than NDOT training through associations.

The main questions the study aims to answer are:

* Whether at-home, tablet-based digital cognitive training is feasible in elderly patients with Mild Cognitive Impairment
* Whether regularly digital cognitive DOT training has a positive effect on patients' cognitive functioning and quality of life
* Whether any potential effects that the cognitive DOT training may have on the patients' cognitive functioning are transferable to the patients' daily life.

Participation in the study includes:

* A pre-training session at the site with the primary project coordinator, where the patient will complete a number of self-report questionnaires about their health, cognition, and quality of life as well as a neuropsychological assessment.
* Training with the digital cognitive DOT training program at home for 20 min. per day 3-4 times a week for 6-8 weeks.
* A post-training session at the site with the primary project coordinator after the 6-8 weeks have passed, where the patient will complete a usability questionnaire about the training programme, some of the same self-report questionnaires about their health, cognition, and quality of life as well as some of the neuropsychological assessments.
* A 1-month follow-up session where the patients will complete some of the same self-report questionnaires again about their cognition and quality of life plus a questionnaire aimed the transferability of any positive cognitive effects of the training.

Conditions

• Mild Cognitive Impairment

Interventions

BEHAVIORAL

Brain Blossom - Gamified Differential Outcome Training

Digital cognitive training with a gamified DOT task for 20 minutes per day 3-4 times a week for 6-8 weeks.

BEHAVIORAL

Gamified Non-Differential Outcome Training

Digital cognitive training with a gamified NDOT task for 20 minutes per day 3-4 times a week for 6-8 weeks.

Sponsors & Collaborators

• Brain+ ApS

  collaborator UNKNOWN

• Eurostars EUREKA

  collaborator UNKNOWN

• Innovation Fund Denmark

  collaborator INDIV

• University of Aarhus

  collaborator OTHER

• Pernille Louise Kjeldsen

  lead OTHER

Principal Investigators

• Jakob U Blicher, Professor · Aalborg University Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

65 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-05-06

Primary Completion

2024-12-31

Completion

2025-01-31

Countries

• Denmark

Study Locations